1007377-55-0
1007377-55-0
Chemical Structure
AKB-6899
- CAS No.: 1007377-55-0
- Formula:C14H11FN2O4
- Molecular Weight:290.25
IUPAC Name: (5-(3-fluorophenyl)-3-hydroxypicolinoyl)glycine
InChIKey: PXWOWORYDKAEJO-UHFFFAOYSA-N
SMILES: O=C(CNC(C1=NC=C(C=C1O)C2=CC=CC(F)=C2)=O)O
Biological Activity: AKB-6899, a prolyl hydroxylase domain 3 (PHD3) inhibitor, is a selective HIF-2α stabilizer. AKB-6899 also increases soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages, and has antitumor and antiangiogenic effects[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AKB-6899 | 99.95% | AKB-6899, a prolyl hydroxylase domain 3 (PHD3) inhibitor, is a selective HIF-2α stabilizer. AKB-6899 also increases soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages, and has antitumor and antiangiogenic effects. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.88
HY-101277Vadadustat -
Similarity Score 0.81
HY-15692PHD2-IN-3 -
Similarity Score 0.69
HY-114726HIF-PHD-IN-5 -
Similarity Score 0.65
HY-15641FG-2216 -
Similarity Score 0.63
HY-159120ZG-2291 -
Similarity Score 0.62
HY-145238FTO-IN-6 -
Similarity Score 0.62
![N-[4-(2-Pyridinyl)benzoyl]glycine-<sup>13</sup>C<sub>2</sub>,<sup>15</sup>N Chemical Structure](//file.medchemexpress.com/product_pic/hy-144348s.gif)
HY-144348SN-[4-(2-Pyridinyl)benzoyl]glycine-13C2,15N -
Similarity Score 0.61
HY-100027ARo 41-1049 hydrochloride -
Similarity Score 0.60
HY-100027Ro 41-1049 -
Explore the MedChemAI to find more analogs
![N-[4-(2-Pyridinyl)benzoyl]glycine-<sup>13</sup>C<sub>2</sub>,<sup>15</sup>N Chemical Structure](http://file.medchemexpress.com/product_pic/hy-144348s.gif)
