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Cat. No.: HY-114726

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HIF-PHD-IN-5

HIF-PHD-IN-5 is a hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD) inhibitor. HIF-PHD-IN-5 can be used for the research of neurological disease.

For research use only. We do not sell to patients.

CAS No.: 170689-51-7
Formula: C₁₂H₁₀N₂O₄
Molecular Weight:246.22

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HIF-PHD-IN-5 Chemical Structure

CAS No.: 170689-51-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
Chemical Information
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Biological Activity

Description

HIF-PHD-IN-5 is a hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD) inhibitor. HIF-PHD-IN-5 can be used for the research of neurological disease^[1].

All HIF/HIF Prolyl-Hydroxylase Isoforms :

In Vitro

HIF-PHD-IN-5 (Compound A4) inhibits the activity of HIF prolyl 4-hydroxylases (PHD1/2/3); stabilizes HIF-1α protein; upregulates the expression of HIF-regulated target genes such as Epo and PGK1; and exerts neuroprotective effects in oxidative stress neuronal models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 170689-51-7
Molecular Weight 246.22
Formula C₁₂H₁₀N₂O₄
SMILES

O=C(O)CNC(=O)C1=NC=2C=CC=CC2C=C1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Rajiv R. Ratan, et al. Prolylhydroxylase inhibitors and methods of use. WO2011106226 A2. 2012-08-23

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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HIF-PHD-IN-5

All HIF/HIF Prolyl-Hydroxylase Isoforms