1. Metabolic Enzyme/Protease
  2. HIF/HIF Prolyl-Hydroxylase

FG-2216 (Synonyms: YM-311)

Cat. No.: HY-15641 Purity: 99.40%
Data Sheet SDS Handling Instructions

FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo.

For research use only. We do not sell to patients.
FG-2216 Chemical Structure

FG-2216 Chemical Structure

CAS No. : 223387-75-5

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $132 In-stock
5 mg $120 In-stock
10 mg $190 In-stock
25 mg $420 In-stock
50 mg $700 In-stock
100 mg $1200 In-stock
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  • Biological Activity

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Description

FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo. IC50 value: 3.9 uM [1] Target: PDH inhibitor FG-2216 was orally bioavailable and induced significant and reversible Epo induction in vivo (82- to 309-fold at 60 mg/kg). Chronic oral dosing in male rhesus macaques was well tolerated, significantly increased erythropoiesis, and prevented anemia induced by weekly phlebotomy. Furthermore, modest increases in HbF-containing red cells and reticulocytes were demonstrated by flow cytometry, though significant increases in HbF were not demonstrated by high-pressure liquid chromatography (HPLC) [2].

References
Molecular Weight

280.66

Formula

C₁₂H₉ClN₂O₄

CAS No.

223387-75-5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 31 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
FG-2216
Cat. No.:
HY-15641
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