1. Metabolic Enzyme/Protease
  2. HIF/HIF Prolyl-Hydroxylase

FG-2216 (Synonyms: YM-311)

Cat. No.: HY-15641 Purity: 99.31%
Handling Instructions

FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo.

For research use only. We do not sell to patients.

FG-2216 Chemical Structure

FG-2216 Chemical Structure

CAS No. : 223387-75-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
25 mg USD 200 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 290 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 490 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo. IC50 value: 3.9 uM [1] Target: PDH inhibitor FG-2216 was orally bioavailable and induced significant and reversible Epo induction in vivo (82- to 309-fold at 60 mg/kg). Chronic oral dosing in male rhesus macaques was well tolerated, significantly increased erythropoiesis, and prevented anemia induced by weekly phlebotomy. Furthermore, modest increases in HbF-containing red cells and reticulocytes were demonstrated by flow cytometry, though significant increases in HbF were not demonstrated by high-pressure liquid chromatography (HPLC) [2].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (110.45 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5630 mL 17.8151 mL 35.6303 mL
5 mM 0.7126 mL 3.5630 mL 7.1261 mL
10 mM 0.3563 mL 1.7815 mL 3.5630 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

280.66

Formula

C₁₂H₉ClN₂O₄

CAS No.

223387-75-5

SMILES

O=C(O)CNC(C1=C(O)C2=C(C(Cl)=N1)C=CC=C2)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
FG-2216
Cat. No.:
HY-15641
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FG-2216

Cat. No.: HY-15641