223387-75-5
223387-75-5
Chemical Structure
FG-2216
Synonym(s): IOX3; YM311
- CAS No.: 223387-75-5
- Formula:C12H9ClN2O4
- Molecular Weight:280.66
IUPAC Name: (1-chloro-4-hydroxyisoquinoline-3-carbonyl)glycine
InChIKey: OUQVKRKGTAUJQA-UHFFFAOYSA-N
SMILES: O=C(O)CNC(C1=C(O)C2=C(C(Cl)=N1)C=CC=C2)=O
Biological Activity: FG-2216 (IOX3) is a potent and orally active inhibitor of HIF prolyl hydroxylase-2 (PHD2), with an IC50 of 3.9 μM. FG-2216 induces robust erythropoietin and modest fetal hemoglobin in vivo[1][2][3].
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FG-2216 | 99.46% | FG-2216 (IOX3) is a potent and orally active inhibitor of HIF prolyl hydroxylase-2 (PHD2), with an IC50 of 3.9 μM. FG-2216 induces robust erythropoietin and modest fetal hemoglobin in vivo. | ||||||||||||||||||||
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FG-2216 (Standard) | ≥98% | FG-2216 (Standard) is the analytical standard of FG-2216. This product is intended for research and analytical applications. FG-2216 (IOX3) is a potent and orally active inhibitor of HIF prolyl hydroxylase-2 (PHD2), with an IC50 of 3.9 μM. FG-2216 induces robust erythropoietin and modest fetal hemoglobin in vivo. | ||||||||||||||||||||
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References
- [1]. Hong YR, et al. [(4-Hydroxyl-benzo[4,5]thieno[3,2-c]pyridine-3-carbonyl)-amino]-acetic acid derivatives; HIF prolyl 4-hydroxylase inhibitors as oral erythropoietin secretagogues. Bioorg Med Chem Lett. 2013 Nov 1;23(21):5953-7. [Content Brief]
- [2]. Hsieh MM, et al. HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. Blood. 2007 Sep 15;110(6):2140-7. [Content Brief]
- [3]. Bernhardt WM, et, al. Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD. J Am Soc Nephrol. 2010 Dec;21(12):2151-6. [Content Brief]
