2 Results for "

tauopathy mouse models

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "tauopathy mouse models" in MCE Product Catalog:

6
6 Cited Publications
Cat. No.: HY-B0478
CAS No.: 25332-39-2
Synonyms: AF-1161
Trazodone hydrochloride (AF-1161) is a triazolopyridine derivative that belongs to the class of serotonin receptor antagonists and reuptake inhibitors (SARIs). Trazodone hydrochloride has anti-depressant and anti-insomnious activity. Trazodone hydrochloride exerts antagonistic properties against a1- and a2-adrenergic receptors and histamine H1 receptors, with minimal anticholinergic effects .
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Cat. No.: HY-P4610
CAS No.: 19653-76-0
Target:  

GLP Receptor

Research Areas:  

Metabolic Disease

H-Trp-Tyr-OH is an orally active tryptophan-tyrosine dipeptide with blood-brain barrier permeability. H-Trp-Tyr-OH exerts physiological regulatory effects by stimulating enteroendocrine cells to secrete glucagon-like peptide GLP-1. In mouse models of tauopathies, H-Trp-Tyr-OH inhibits tau phosphorylation, reduces the level of neurofibrillary tangles, increases dopamine turnover, upregulates synapsin expression, and elevates cecal short-chain fatty acid levels, thereby improving behavioral deficits and extending lifespan. H-Trp-Tyr-OH can be used in research related to impaired glucose tolerance and tauopathies .
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