5 Results for "

voltage-sensor domains

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "voltage-sensor domains" in MCE Product Catalog:

Corza6
Corza6
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Cat. No.: HY-P10817
Target:  

Proton Pump Reactive Oxygen Species (ROS)

Research Areas:  

Metabolic Disease

Corza6 is a potent and selective human voltage-gated proton channel (hHv1) peptide inhibitor. Corza6 binds to the external voltage sensor domain (VSD) loop in hHv1 with a Kd of ~1 nM at the natural, hyperpolarized resting membrane potential (RMP) of mammalian cells. Corza6 allows capacitation in sperm and permits sustained reactive oxygen species (ROS) production in white blood cells (WBCs) .
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Corza6 TFA
Corza6 TFA
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Cat. No.: HY-P10817A
Target:  

Proton Pump Reactive Oxygen Species (ROS)

Research Areas:  

Metabolic Disease

Corza6 TFA is a potent and selective human voltage-gated proton channel (hHv1) peptide inhibitor. Corza6 TFA binds to the external voltage sensor domain (VSD) loop in hHv1 with a Kd of ~1 nM at the natural, hyperpolarized resting membrane potential (RMP) of mammalian cells. Corza6 TFA allows capacitation in sperm and permits sustained reactive oxygen species (ROS) production in white blood cells (WBCs) .
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ProTx-I
ProTx-I
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Cat. No.: HY-P1073
CAS No.: 484598-35-8
Target:  

Calcium Channel Potassium Channel Sodium Channel TRP Channel

Research Areas:  

Neurological Disease Cancer

ProTx-I is a toxin derived from Thrixopelma pruriens and a peptide inhibitor targeting TTX-resistant sodium channels. ProTx-I interacts with voltage sensors of multiple domains such as NaV1.7, reduces neuronal excitability through allosteric modulation of channel gating and alteration of voltage dependence. The IC50 values of ProTx-I against human NaV1.7, NaV1.2, NaV1.6, and NaV1.5 are 95 nM, 104 nM, 21 nM, and 358 nM, respectively; ProTx-I also potently inhibits Ba 2+ currents of hCav3.1, while its inhibitory potency against hCav3.2 is approximately 160-fold lower. ProTx-I is applicable to the research of chronic pain .
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GX-936
GX-936
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Cat. No.: HY-123414
CAS No.: 1235406-09-3
Synonyms: PF-05196233
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

GX-936 (PF-05196233), a potent and Nav1.7-subtype selective inhibitor, binds to the activated state of voltage-sensor domain IV (VSD4) .
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TRPV4 antagonist-7
TRPV4 antagonist-7
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Cat. No.: HY-187364
CAS No.: 3050594-88-9
Target:  

TRP Channel Cytochrome P450

Research Areas:  

Inflammation/Immunology

TRPV4 antagonist-7 is a potent and selective TRPV4 antagonist with an IC50 of 0.2 nM against human targets. TRPV4 antagonist-7 binds to the voltage-sensor-like domain cavity of TRPV4 and inhibits channel activity through the formation of salt bridges, hydrogen bonds, and edge-to-face π-stacking interactions. TRPV4 antagonist-7 induces phospholipid accumulation in HepG2 C3A cells in vitro with an IC50 of 3.8 μM, and exhibits moderate inhibitory effects on CYP2D6 with an IC50 of 5.1 μM. TRPV4 antagonist-7 dose-dependently inhibits GSK1016790A (HY-19608)-induced bronchoconstriction in rats and cough in guinea pigs. TRPV4 antagonist-7 can be used in studies related to respiratory system diseases .
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