zwitterionic surfactant

CHAPS is a cholic acid-derived, sulfobetaine-type zwitterionic detergent and micelle-forming agent. CHAPS exhibits properties of weak cationic or nonionic surfactants in different solution systems, undergoes micellization, and forms small, loose hydrophilic aggregates that are temperature-dependent. CHAPS stabilizes mononucleosomes under different ionic strengths, reduces nucleosome sequence specificity, promotes sliding of histone cores along DNA, solubilizes Tamm-Horsfall protein to reduce its interference with urinary exosome isolation, and maintains vesicle structure and the activity of related proteins at the same time. CHAPS is used to recover native folded fusion proteins, enhance the binding capacity of GST fusion proteins, and restore GST enzyme activity. However, CHAPS cannot refold proteins denatured by urea, guanidine hydrochloride or heat, nor can it construct the structure of intrinsically disordered proteins. CHAPS is commonly used in research on the separation and purification of membrane proteins .

Lauryl hydroxysultaine, 35% in H2O (LHSB) is a zwitterionic surfactant used in mid-to-high-end shampoos and body washes. Lauryl hydroxysultaine, 35% in H2O can also be applied in oil extraction, metal rust-preventive cleaners, paint removers, hard surface cleaners, and other fields .

Tetradecylphosphocholine is a zwitterionic surfactant that can be used as a detergent for membrane protein solubilization .

CHAPS (Standard) is the analytical standard of CHAPS. This product is intended for research and analytical applications. CHAPS, a derivative of Cholic acid, is a zwitterionic detergent for solubilizing membrane proteins. CHAPS is used for stabilization of various protein-DNA complexes and can retain biochemical activity of proteins in solution .