MUC4 - mucin 4, cell surface associated Gene

Also Known as ASGP; MUC-4; HSA276359

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4585

About MUC4

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:195,746,771-195,811,929 (from NCBI)

This gene has 22 transcripts (splice variants), 1 gene allele, 84 orthologues, 2 paralogues and is associated with 125 phenotypes. Biased expression in colon (RPKM 10.3), esophagus (RPKM 2.1) and 4 other tissues.

Summary

The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008]

MUC4 Products (4)

mRNA Protein Name
NM_001322468.1 NP_001309397.1 mucin-4 isoform f precursor
NM_004532.6 NP_004523.3 mucin-4 isoform d precursor
NM_018406.7 NP_060876.5 mucin-4 isoform a precursor
NM_138297.5 NP_612154.2 mucin-4 isoform e precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in maintenance of gastrointestinal epithelium IMP
IMP: Inferred from mutant phenotype
17058067 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MUC4 Protein Structure

NIDO

NIDO: Nidogen-like (4468 - 4551)

AMOP

AMOP: AMOP domain (4557 - 4668)

VWD

VWD: von Willebrand factor type D domain (4683 - 4854)

  • 0
  • 900
  • 1800
  • 2700
  • 3600
  • 4500
  • 5412 a.a.
Protein Preferred Names Protein Names

mucin-4

  • ascites sialoglycoprotein

MUC4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83519 Mucin 4 Antibody (YA3264) WB Human
HY-P83519A Mucin 4 Antibody (YA3264)(PBS only) WB Human
HY-P86040 Mucin 4 Antibody (YA5732) IHC-P, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Biliary Tract Cancer

  • Malignant Tumour Of Biliary Tract

  • Biliary Tract Neoplasms

  • Biliary Tract Neoplasm
Intrahepatic Cholangiocarcinoma

  • Cholangiocarcinoma

  • Intrahepatic Bile Duct Carcinoma

  • Peripheral Cholangiocarcinoma

  • Peripheral Intrahepatic Cholangiocarcinoma

  • Adenocarcinoma Of Intra-Hepatic Bile Ducts

  • Cholangiocarcinoma, Unspecified Site

  • Cholangiocarcinoma Of Liver
Mucoepidermoid Carcinoma

  • Mec

  • Salivary Gland Mucoepidermoid Carcinoma

  • C3772

  • Carcinoma Mucoepidermoid

  • Carcinoma, Mucoepidermoid
Adenosquamous Carcinoma

  • Adenosquamous Cell Carcinoma

  • Mixed Adenocarcinoma And Squamous Carcinoma

  • Carcinoma Adenosquamous

  • Carcinoma, Adenosquamous
Adenocarcinoma

  • Adenocarcinomas

  • Adenoacanthoma Of Unspecified Site

  • Adenocarcinoid Of Unspecified Site

  • Adenocarcinoid Tumour Of Unspecified Site

  • Adenocarcinoma And Carcinoid Combined Of Unspecified Site

  • Adenocarcinoma Nos
Pancreatic Adenocarcinoma

  • Adenocarcinoma Of The Pancreas

  • Adenocarcinoma Of Pancreas

  • Pancreas Adenocarcinoma

  • Malignant Exocrine Neoplasm

  • Primary Pancreatic Adenocarcinoma

  • Adenocarcinoma Of Islet Cell Of Pancreas

  • Islet Cell Adenocarcinoma Of Unspecified Site

  • Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Dry Eye Syndrome

  • Dry Eye Syndromes

  • Dry Eye Disease

  • Tear Film Insufficiency

  • Xerophthalmia
Pancreatitis

  • Mumps Pancreatitis
Cholangiocarcinoma

  • Cholangiocarcinoma, Susceptibility To

  • Extrahepatic Cholangiocarcinoma

  • Intrahepatic Cholangiocarcinoma

  • Chlc

  • Chlc, Susceptibility To

  • Cc

  • Cholangiocarcinoma Of Biliary Tract

  • Cholangiocellular Carcinoma

  • Distal Cholangiocarcinoma

  • Perihilar Cholangiocarcinoma

  • Bile Duct Cancer

  • Cca

  • Adult Primary Cholangiocellular Carcinoma

  • Bile Duct Carcinoma
Adenomyoma
Myxofibrosarcoma

  • Fibromyxosarcoma

  • Fibromyxoid Sarcoma

  • Myxoid Malignant Fibrous Histiocytoma

  • Dermatofibrosarcoma Protuberans, Myxoid
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Bile Duct Mucoepidermoid Carcinoma

  • Mucoepidermoid Carcinoma Of The Bile Duct

  • Extrahepatic Bile Duct Mucoepidermoid Carcinoma
Bile Duct Cancer

  • Bile Duct Carcinoma

  • Extrahepatic Bile Duct Carcinoma

  • Carcinoma Of Extrahepatic Bile Duct

  • Extrahepatic Bile Duct Cancer

  • Bile Duct Neoplasms

  • Bile Duct Tumor

  • Ca Extrahepatic Bile Ducts

  • Malignant Neoplasm Of The Extrahepatic Bile Duct

  • Bile Duct Extrahepatic Carcinoma

  • Malignant Tumor Of Extrahepatic Bile Duct
Chronic Ethmoiditis

  • Chronic Ethmoidal Sinusitis

  • Chronic Ethmoid Sinusitis

  • Ethmoidal Sinusitis - Chronic
Bronchiolo-Alveolar Adenocarcinoma

  • Bronchioloalveolar Carcinoma

  • Bronchioalveolar Lung Carcinoma

  • Minimally Invasive Lung Adenocarcinoma

  • Carcinoma Bronchioloalveolar

  • Adenocarcinoma, Bronchiolo-Alveolar

  • Bronchioloalveolar Adenocarcinoma
Cystadenoma

  • Cystoma

  • Craniopharyngioma
Otitis Media

  • Opsoclonus-Myoclonus Syndrome

  • OMS

  • Otitis Media, Susceptibility To

  • Kinsbourne Syndrome

  • Otitis Media, Chronic/Recurrent

  • Come/Rom

  • Ataxo-Opso-Myoclonus Syndrome

  • Dancing Eye Syndrome

  • Dancing Eye-Dancing Feet Syndrome

  • Oma Syndrome

  • Opsoclonus Myoclonus Syndrome

  • Opsoclonus-Myoclonus-Ataxia Syndrome

  • Poma Syndrome

  • Paraneoplastic Opsoclonus-Myoclonus

  • Paraneoplastic Opsoclonus-Myoclonus-Ataxia Syndrome

  • Opsoclonus Myoclonus

  • OM

  • {Otitis Media, Susceptibility To}

  • Infectious Otitis Media
Kidney Fibrosarcoma

  • Fibrosarcoma Of The Kidney
Gallbladder Signet Ring Cell Adenocarcinoma

  • Signet Ring Cell Carcinoma Of The Gallbladder
Mucinous Tubular And Spindle Renal Cell Carcinoma

  • Mucinous Tubular And Spindle Cell Renal Carcinoma
Jugular Foramen Meningioma

  • Meningioma Of The Jugular Foramen
Cholecystitis

  • Acute Cholecystitis

  • Chronic Cholecystitis

  • Acalculous Cholecystitis

  • Acute And Chronic Cholecystitis

  • Acute On Chronic Cholecystitis

  • Gallstone Cholecystitis

  • Cholecystitis, Acute

  • Calculus Of Gallbladder With Cholecystitis

  • Gallbladder Inflammation

  • Acute Cholecystitis Infection

  • Acute Acalculous Cholecystitis

  • Chronic Acalculous Cholecystitis

  • Nonfunctioning Gallbladder
Gastric Adenocarcinoma

  • Adenocarcinoma Of Stomach

  • Stomach Adenocarcinoma

  • Adenocarcinoma Gastric

  • Intestinal Type Adenocarcinoma Of Unspecified Site

  • Diffuse Type Adenocarcinoma Of Unspecified Site
Filamentary Keratitis
Bile Duct Mucinous Adenocarcinoma

  • Mucinous Carcinoma Of The Bile Duct

  • Extrahepatic Bile Duct Mucinous Adenocarcinoma
Breast Secretory Carcinoma

  • Secretory Breast Carcinoma

  • Juvenile Breast Carcinoma

  • Juvenile Carcinoma Of The Breast

  • Juvenile Secretory Carcinoma Of Breast

  • Juvenile Breast Cancer

  • Sbc

  • Secretory Carcinoma Of The Breast
Ossifying Fibromyxoid Tumor

  • Ossifying Fibromyxoid Tumour

  • Ossifying Fibromyxoma
Intravascular Fasciitis

  • Intravascular Pseudosarcomatous Fasciitis
Pancreatic Signet Ring Cell Adenocarcinoma

  • Pancreatic Signet Ring Cell Carcinoma

  • Signet Ring Cell Carcinoma Of Pancreas
Cystic Fibrosis

  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis
Lacrimal Apparatus Disease

  • Lacrimal Apparatus Diseases
Pseudosarcomatous Fibromatosis

  • Nodular Fasciitis

  • Pseudosarcomatous Fasciitis

  • Fasciitis - Nodular

  • Fasciitis Nodular
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Blepharitis
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Lung Cancer Susceptibility 3

  • Lung Adenocarcinoma

  • Adenocarcinoma Of Lung

  • LNCR3

  • Adenocarcinoma Of Lung, Susceptibility To

  • Bronchogenic Lung Adenocarcinoma

  • Nonsmall Cell Adenocarcinoma

  • Adenocarcinoma Lung

  • Lung Adenocarcinomas

  • Non-Small Cell Adenocarcinoma
Esophageal Cancer

  • Esophageal Carcinoma

  • Carcinoma Of Esophagus

  • Esophageal Squamous Cell Carcinoma, Somatic

  • Esophageal Carcinoma, Somatic

  • Esophagus Cancer

  • Gastric Cardia Adenocarcinoma

  • Esophageal Neoplasms

  • Esophageal Cancer, Somatic

  • Cancer Of Esophagus

  • Cancer Of Oesophagus

  • Carcinoma Of Oesophagus

  • Ca Lower Third Oesophagus

  • Ca Middle Third Oesophagus

  • Malignant Neoplasm Of Distal Third Of Esophagus

  • Malignant Neoplasm Of Lower Third Of Oesophagus

  • Malignant Neoplasm Of Middle Third Of Oesophagus

  • Malignant Neoplasm Of Proximal Third Of Esophagus

  • Malignant Neoplasm Of Upper Third Esophagus

  • Malignant Tumor Of Abdominal Esophagus

  • Malignant Tumor Of Distal Third Of Esophagus

  • Malignant Tumor Of Proximal Third Of Esophagus

  • Malignant Tumor Of The Middle Third Of The Esophagus

  • ESCR

  • Aerodigestive Tract Cancer

  • Escc

  • Esophageal Squamous Cell Carcinoma

  • Cancer, Esophageal

  • Malignant Neoplasm Of Esophagus

  • Squamous Cell Carcinoma Of Esophagus

  • Malignant Neoplasm Of Middle Third Of Esophagus
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS19923 Muc4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08843 MUC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26425 Muc4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MUC4 VGNC VGNC:56235
Rattus norvegicus MUC4 RGD RGD:621331
Felis catus MUC4 VGNC VGNC:102778
Canis familiaris MUC4 VGNC VGNC:59068
Macaca mulatta MUC4 VGNC VGNC:110352
Mus musculus MUC4 MGD MGI:2153525