Mucin 4 Antibody (YA5732)

Cat. No.: HY-P86040: Data Sheet COA
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Mucin 4 Antibody (YA5732) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Mucin 4.

For research use only. We do not sell to patients.

Size	Stock	Quantity
Free Sample	Apply now
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Mucin 4 Antibody (YA5732) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Mucin 4.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 231 kDa;

Species Reactivity

Human

SwissProt ID

Q99102

Gene ID

4585 [NCBI]

Immunogen

Synthesized peptide derived from human MUC4 AA range: 2000-2100

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-400
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-200
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:500-5000

Purity	affinity chromatography.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG2a

Appearance

Liquid

Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces (PubMed:10880978). These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation (PubMed:10880978). Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation

Subcellular Localization：Cell membrane; Single-pass membrane protein; Cell membrane; Secreted; Cell membrane; Single-pass membrane protein; Secreted; Secreted; Cell membrane; Single-pass membrane protein

Expression：
Tissue_specificity:This gene is expressed in the thymus, thyroid gland, lungs, trachea, esophagus, stomach, small intestine, colon, testes, prostate, ovaries, uterus, placenta, as well as mammary glands and salivary glands. It is also expressed in carcinomas originating from some of these epithelial tissues, such as lung cancer, squamous cell carcinoma of the upper respiratory and digestive tract, breast cancer, biliary tract cancer, colon cancer, and cervical cancer. It is expressed at very low levels or not at all in normal pancreas or chronic pancreatitis, but is highly expressed in pancreatic tumors and pancreatic tumor cell lines.

Isoforms & Post-Translational Modification：Q99102 has 14 isomers: Q99102-1: 542307 Da (predicted); Q99102-2: 429631 Da (predicted); Q99102-3: 504936 Da (predicted); Q99102-5: 436140 Da (predicted); Q99102-7: 434209 Da (predicted); Q99102-8: 433835 Da (predicted); Q99102-9: 424339 Da (predicted); Q99102-10: 536223 Da (predicted); Q99102-11: 432689 Da (predicted); Q99102-12: 125130 Da (predicted); Q99102-13: 130415 Da (predicted); Q99102-15: 431438 Da (predicted); Q99102-16: 455635 Da (predicted); Q99102-17: 517394 Da (predicted).
Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain;Highly O-glycosylated;Is predominantly N-glycosylated

Subunit：A heterodimeric complex, composed of a mucin-4 alpha chain and a cysteine-rich transmembrane mucin-4 beta chain. Mucin-4 beta chain interacts with ERBB2 via the EGF-like domain 1. In nonpolarized cells, associates with ERBB2 and ERBB3

Synonyms

Mucin-4; MUC-4; Ascites sialoglycoprotein; ASGP; Pancreatic adenocarcinoma mucin; Testis mucin; Tracheobronchial mucin; [Cleaved into: Mucin-4 alpha chain; Ascites sialoglycoprotein 1; ASGP-1; Mucin-4 beta chain; Ascites sialoglycoprotein 2; ASGP-2; ]

Documentation

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Data Sheet (234 KB) SDS (252 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)