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Mucin 4 Antibody (YA5732)

(Synonyms: Mucin-4; MUC-4; Ascites sialoglycoprotein; ASGP; Pancreatic adenocarcinoma mucin; Testis mucin; Tracheobronchial mucin; [Cleaved into: Mucin-4 alpha chain; Ascites sialoglycoprotein 1; ASGP-1; Mucin-4 beta chain; Ascites sialoglycoprotein 2; ASGP-2; ])
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Mucin 4 Antibody (YA5732) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Mucin 4.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2a

  • Application:

    IHC-P, ICC/IF, ELISA

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

  • Conjugation:
    Non-conjugated
  • Mucin 4 Antibody (YA5732) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:200-400 1:50-200 1:500-5000

Product Details

Description

Mucin 4 Antibody (YA5732) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Mucin 4.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human
  • Calculated Molecular Weight Predicted band size: 231 kDa;
Immunogen

Synthesized peptide derived from human MUC4 AA range: 2000-2100

Purification

affinity chromatography.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG2a

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    Mucin 4 is a Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces. These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation. Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation[1].

  • Subcellular Localization

    Cell membrane; Single-pass membrane protein; Cell membrane; Secreted; Cell membrane; Single-pass membrane protein; Secreted; Secreted; Cell membrane; Single-pass membrane protein

  • Expression


    Tissue_specificity:This gene is expressed in the thymus, thyroid gland, lungs, trachea, esophagus, stomach, small intestine, colon, testes, prostate, ovaries, uterus, placenta, as well as mammary glands and salivary glands. It is also expressed in carcinomas originating from some of these epithelial tissues, such as lung cancer, squamous cell carcinoma of the upper respiratory and digestive tract, breast cancer, biliary tract cancer, colon cancer, and cervical cancer. It is expressed at very low levels or not at all in normal pancreas or chronic pancreatitis, but is highly expressed in pancreatic tumors and pancreatic tumor cell lines.

  • Isoforms & Post-Translational Modification

    Q99102 has 14 isomers: Q99102-1: 542307 Da (predicted); Q99102-2: 429631 Da (predicted); Q99102-3: 504936 Da (predicted); Q99102-5: 436140 Da (predicted); Q99102-7: 434209 Da (predicted); Q99102-8: 433835 Da (predicted); Q99102-9: 424339 Da (predicted); Q99102-10: 536223 Da (predicted); Q99102-11: 432689 Da (predicted); Q99102-12: 125130 Da (predicted); Q99102-13: 130415 Da (predicted); Q99102-15: 431438 Da (predicted); Q99102-16: 455635 Da (predicted); Q99102-17: 517394 Da (predicted).
    Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain;Highly O-glycosylated;Is predominantly N-glycosylated

  • Subunit

    A heterodimeric complex, composed of a mucin-4 alpha chain and a cysteine-rich transmembrane mucin-4 beta chain. Mucin-4 beta chain interacts with ERBB2 via the EGF-like domain 1. In nonpolarized cells, associates with ERBB2 and ERBB3

  • SwissProt ID

    Q99102

  • Gene ID
    4585 [NCBI]
  • Synonyms

    Mucin-4; MUC-4; Ascites sialoglycoprotein; ASGP; Pancreatic adenocarcinoma mucin; Testis mucin; Tracheobronchial mucin; [Cleaved into: Mucin-4 alpha chain; Ascites sialoglycoprotein 1; ASGP-1; Mucin-4 beta chain; Ascites sialoglycoprotein 2; ASGP-2; ]

Mucin 4 Antibody (YA5732) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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