Mucin 4 Antibody (YA3264)(PBS only)
(Synonyms: Mucin-4; Ascites sialoglycoprotein; ASGP; Pancreatic adenocarcinoma mucin; Testis mucin; Tracheobronchial mucin)Mucin 4 Antibody (YA3264) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Mucin 4.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
Mucin 4 Antibody (YA3264) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Mucin 4.
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Host Rabbit
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 120 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 542 kDa
Recombinant protein of human MUC4
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Mucin 4 is a Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces. These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation. Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation[1].
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Subcellular Localization
Cell membrane; Single-pass membrane protein; Cell membrane; Secreted; Cell membrane; Single-pass membrane protein; Secreted; Secreted; Cell membrane; Single-pass membrane protein
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Expression
Tissue_specificity:This gene is expressed in the thymus, thyroid gland, lungs, trachea, esophagus, stomach, small intestine, colon, testes, prostate, ovaries, uterus, placenta, as well as mammary glands and salivary glands. It is also expressed in carcinomas originating from some of these epithelial tissues, such as lung cancer, squamous cell carcinoma of the upper respiratory and digestive tract, breast cancer, biliary tract cancer, colon cancer, and cervical cancer. It is expressed at very low levels or not at all in normal pancreas or chronic pancreatitis, but is highly expressed in pancreatic tumors and pancreatic tumor cell lines. -
Isoforms & Post-Translational Modification
Q99102 has 14 isomers: Q99102-1: 542307 Da (predicted); Q99102-2: 429631 Da (predicted); Q99102-3: 504936 Da (predicted); Q99102-5: 436140 Da (predicted); Q99102-7: 434209 Da (predicted); Q99102-8: 433835 Da (predicted); Q99102-9: 424339 Da (predicted); Q99102-10: 536223 Da (predicted); Q99102-11: 432689 Da (predicted); Q99102-12: 125130 Da (predicted); Q99102-13: 130415 Da (predicted); Q99102-15: 431438 Da (predicted); Q99102-16: 455635 Da (predicted); Q99102-17: 517394 Da (predicted).
Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain;Highly O-glycosylated;Is predominantly N-glycosylated -
Subunit
A heterodimeric complex, composed of a mucin-4 alpha chain and a cysteine-rich transmembrane mucin-4 beta chain. Mucin-4 beta chain interacts with ERBB2 via the EGF-like domain 1. In nonpolarized cells, associates with ERBB2 and ERBB3
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SwissProt ID
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Synonyms
Mucin-4; Ascites sialoglycoprotein; ASGP; Pancreatic adenocarcinoma mucin; Testis mucin; Tracheobronchial mucin
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Research Field
Microbiology
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