CXCL6 - C-X-C motif chemokine ligand 6 Gene

Also Known as GCP2; CKA-3; GCP-2; SCYB6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6372

About CXCL6

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:73,836,678-73,838,760 (from NCBI)

This gene has 3 transcripts (splice variants), 75 orthologues and 12 paralogues. Biased expression in spleen (RPKM 44.2), gall bladder (RPKM 20.7) and 4 other tissues.

Summary

The protein encoded by this gene is a member CXC chemokine family. The encoded protein is a chemotactic for neutrophil granulocytes and has Antibacterial action against gram-negative and gram-positive bacteria. This gene and Other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, Jun 2020]

CXCL6 Products (1)

mRNA	Protein	Name
NM_002993.4	NP_002984.1	C-X-C motif chemokine 6 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables chemokine activity	IDA IDA: Inferred from direct assay	8399143	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28381538	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	8399143	GOA
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	8399143	GOA
involved in neutrophil activation	IDA IDA: Inferred from direct assay	8399143	GOA
involved in neutrophil chemotaxis	IDA IDA: Inferred from direct assay	8399143	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CXCL6 Protein Structure

IL8

0
100
114 a.a.

Protein Preferred Names	Protein Names
C-X-C motif chemokine 6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)

CXCL6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CXCL6	P80162	PF4	Homo sapiens	P02776	SPR	28381538
Intra	CXCL6	P80162	CCL5	Homo sapiens	P13501	SPR	28381538
Intra	CXCL6	P80162	CXCL12	Homo sapiens	P48061	SPR	28381538

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CXCL6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72677	GCP-2/CXCL6 Protein, Human (HEK293, His)	P80162 (G38-N114)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700048AF	Animal-Free GCP-2/CXCL6 Protein, Human (His)	P80162 (V40-N114)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Tonsillitis	Chronic Tonsillitis Throat Infection - Tonsillitis
Mastitis	Breast Inflammation Inflammatory Breast Disease Inflammatory Disease Of Breast Inflammation Of Non-Human Mammary Gland Inflammatory Disorder Of Breast Mastitis Nos Acute Mastitis Nos Acute Nonpuerperal Mastitis Nonpuerperal Mastitis Nos Subacute Mastitis Nos
Sodoku Disease	Spirillosis Sodoku Spirillary Fever Rat-Bite Fever Rat-Bite Fever Due To Spirillum Minus Spirillary Rat-Bite Fever Sokosho
Gastroduodenitis
Hyperinsulinemic Hypoglycemia, Familial, 5	Hyperinsulinism Due To Insr Deficiency HHF5 Familial Hyperinsulinemic Hypoglycemia 5 Hyperinsulinemic Hypoglycemia Due To Insr Deficiency Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency Congenital Hyperinsulinism Persistent Hyperinsulinemic Hypoglycemia Of Infancy Phhi Hyperinsulinemic Hypoglycemia Familial 5
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16639	Cxcl5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03394	CXCL6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24115	Cxcl6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CXCL6	RGD	RGD:708540
Mus musculus	CXCL6	MGD	MGI:1096868
Macaca mulatta	CXCL6	VGNC	VGNC:106565
Others	CXCL6	NCBI