2. Inhibitory Antibodies
  3. Topsalysin

Topsalysin  (Synonyms: PRX-302)

Cat. No.: HY-P99554

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Topsalysin is a PSA-activated protoxin, a pore-forming protein (synthetic proaerolysin) fusion protein with human prostate-specific antigen. Topsalysin has tumor suppression effect in mice modle.

For research use only. We do not sell to patients.

Topsalysin Chemical Structure

Topsalysin Chemical Structure

CAS No. : 917121-25-6

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Topsalysin Related Antibodies

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Description

Topsalysin is a PSA-activated protoxin, a pore-forming protein (synthetic proaerolysin) fusion protein with human prostate-specific antigen. Topsalysin has tumor suppression effect in mice modle[1].

In Vitro

Topsalysin (19 pM-10 nM; 48 h) shows prostate-specific antigen (PSA)-dependent toxicity against LNCaP, PC3, DU145, and TSU cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Topsalysin Related Antibodies
In Vivo

Topsalysin (intratumor injection; 1-10 μg/mouse; single dose) inhibits tumor growth in mice bearing[1].
Topsalysin (0.35, 4.1, 25.8 μg/kg, 25 μL; i.p.; single dose) could kill up to 50% of cells in the injected site of cynomolgus monkey prostate glands[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (6-week-old) subcutaneously bearing tumors[1]
Dosage: 0, 1, 5, and 10 μg
Administration: Intratumor injection; single dose; measured tumor sizes at first day and twice weekly for 28 days
Result: Showed prostate-specific antigen (PSA)-dependent toxicity in mice.
Clinical Trial
CAS No.
SMILES

[Topsalysin]
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topsalysin917121-25-6PRX-302PRX302PRX 302OthersInhibitorinhibitorinhibit

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