Topsalysin
Topsalysin is a PSA-activated protoxin, a pore-forming protein (synthetic proaerolysin) fusion protein with human prostate-specific antigen. Topsalysin has tumor suppression effect in mice modle.
For research use only. We do not sell to patients.
- CAS No.: 917121-25-6
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Topsalysin (19 pM-10 nM; 48 h) shows prostate-specific antigen (PSA)-dependent toxicity against LNCaP, PC3, DU145, and TSU cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Topsalysin (0.35, 4.1, 25.8 μg/kg, 25 μL; i.p.; single dose) could kill up to 50% of cells in the injected site of cynomolgus monkey prostate glands[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nude mice (6-week-old) subcutaneously bearing tumors[1]
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Dosage:0, 1, 5, and 10 μg
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Administration:Intratumor injection; single dose; measured tumor sizes at first day and twice weekly for 28 days
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Result:Showed prostate-specific antigen (PSA)-dependent toxicity in mice.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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proaerolysin (engineered with a PSA cutting site)-hexahistidine
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 917121-25-6
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SMILES
[Topsalysin]
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Synonyms
PRX-302
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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