ANGPTL8 - angiopoietin like 8 Gene

Also Known as RIFL; TD26; PRO1185; PVPA599; C19orf80

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55908

About ANGPTL8

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:11,239,619-11,241,943 (from NCBI)

This gene has 4 transcripts (splice variants) and 90 orthologues. Biased expression in liver (RPKM 32.5) and fat (RPKM 10.2).

Summary

Predicted to enable hormone activity. Involved in regulation of lipid metabolic process and triglyceride homeostasis. Acts upstream of or within positive regulation of protein processing and regulation of lipoprotein metabolic process. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

ANGPTL8 Products (1)

mRNA Protein Name
NM_018687.7 NP_061157.3 angiopoietin-like protein 8 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21988832 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of protein processing IDA
IDA: Inferred from direct assay
23150577 GOA
involved in regulation of lipid metabolic process IDA
IDA: Inferred from direct assay
25417115 GOA
acts upstream of or within regulation of lipoprotein metabolic process IMP
IMP: Inferred from mutant phenotype
23150577 GOA
involved in triglyceride homeostasis IDA
IDA: Inferred from direct assay
25417115 GOA
acts upstream of or within triglyceride homeostasis IGI
IGI: Inferred from genetic interaction
23150577 GOA
NOT involved in type B pancreatic cell proliferation IDA
IDA: Inferred from direct assay
25417115 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
23150577 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

angiopoietin-like protein 8

  • hepatocellular carcinoma-associated gene TD26

ANGPTL8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ANGPTL8 Q6UXH0 RCHY1 Homo sapiens Q96PM5
Anti Tag CoIP
21988832
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ANGPTL8 Proteins

Cat. No. Product Name Accession Purity
HY-P7506 ANGPTL8/Angiopoietin-like 8 Protein, Human (HEK293, Fc) Q6UXH0 (A22-A198) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Hypobetalipoproteinemia, Familial, 2

  • Familial Hypobetalipoproteinemia 2

  • FHBL2

  • Hypolipidemia, Familial, Combined

  • Combined Familial Hypolipidemia

  • Combined Hypobetalipoproteinemia Familial

  • Hypobetalipoproteinemia, Familial, Type 2
Diabetes Mellitus

  • Diabetes
Familial Hyperlipidemia

  • Familial Hyperlipoproteinemia

  • Hyperlipidaemia

  • Hyperlipoproteinemias

  • Hyperlipidemia

  • Hyperlipemia

  • Hyperlipidemias
Non-Alcoholic Fatty Liver Disease

  • Fatty Liver

  • Non-Alcoholic Fatty Liver

  • Nafld

  • Nonalcoholic Fatty Liver Disease

  • Nonalcoholic Steatohepatitis

  • Steatosis

  • Nafl

  • Nash

  • Non-Alcoholic Steatohepatitis

  • Susceptibility To Nonalcoholic Fatty Liver Disease

  • Steatohepatitis

  • Fatty Degeneration

  • Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis

  • Nafld Without Nash

  • Nafld Without Mention Of Nash
Prader-Willi Syndrome

  • Prader-Labhart-Willi Syndrome

  • PWS

  • Willi-Prader Syndrome

  • Prader-Willi Syndrome Due To Translocation

  • Prader-Willi Syndrome Due To Imprinting Mutation

  • Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

  • Prader Willi Syndrome

  • Upd(15)Mat
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Spinal Muscular Atrophy, Type Iii

  • SMA3

  • Juvenile Spinal Muscular Atrophy

  • Kugelberg-Welander Disease

  • Sma Iii

  • Kugelberg-Welander Syndrome

  • Kws

  • Muscular Atrophy, Juvenile

  • Spinal Muscular Atrophy, Mild Childhood And Adolescent Form

  • Spinal Muscular Atrophy-3

  • Spinal Muscular Atrophy Type 3

  • Spinal Muscular Atrophy, Type Iii, Modifier Of

  • Type Iii Spinal Muscular Atrophy

  • Sma 3

  • Proximal Spinal Muscular Atrophy Type 3

  • Sma Type 3

  • Sma Type Iii

  • Sma-Iii

  • Spinal Muscular Atrophy 3

  • Spinal Muscular Atrophy Mild Childhood And Adolescent Form

  • Spinal Muscular Atrophy Type Iii

  • Wohlfart-Kugelberg-Welander Disease

  • Atrophy, Muscular, Spinal, Type Iii
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990336 Anti-ANGPTL8 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ANGPTL8 MGD MGI:3643534
Rattus norvegicus ANGPTL8 RGD RGD:2320121
Macaca mulatta ANGPTL8 VGNC VGNC:69691
Canis familiaris ANGPTL8 VGNC VGNC:37864
Bos taurus ANGPTL8 VGNC VGNC:25896
Felis catus ANGPTL8 VGNC VGNC:69346
Others ANGPTL8 NCBI