SM-8849
SM-8849 is a thiazole derivative with anti-arthritis activity. SM-8849 specifically targets and inactivates T cells involved in delayed-type hypersensitivity (DTH) reactions, thereby inhibiting the core immunopathological process of arthritis, but has little effect on the humoral immune process such as antibody production. In a mouse arthritis model induced by Type II Collagen (HY-NP003), SM-8849 significantly alleviated clinical symptoms, reduced bone destruction and joint damage. SM-8849 can be used for the study of autoimmune diseases such as rheumatoid arthritis.
For research use only. We do not sell to patients.
- CAS No.: 113759-19-6
- Formula: C18H17FN2S
- Molecular Weight:312.40
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Chemical Information
-
CAS No. 113759-19-6
-
Molecular Weight 312.40
-
Formula C18H17FN2S
-
SMILES
FC1=C(C2=CC=CC=C2)C=CC(C(C)C3=CSC(NC)=N3)=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Nagai H, et al. The effect of SM-8849 on experimental arthritis in mice. Pharmacology. 1996 Jun;52(6):377-86. [Content Brief]
[2]. Nishikaku F, Koga Y. Suppression of murine collagen-induced arthritis by treatment with a novel thiazole derivative, SM-8849. Immunopharmacology. 1993 Jan-Feb;25(1):65-74. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SM-8849 Related Classifications
HY-165564 Related Classifications
Powered by Bioz