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Cat. No.: HY-184585

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UT-B-IN-2

UT-B-IN-2 is an orally active UT-B inhibitor, with an IC₅₀ of 0.11 μM in mice and 0.054 μM in rats. UT-B-IN-2 induces diuretic effects in rats. UT-B-IN-2 can be used in the research of cardiovascular diseases and edema-related diseases.

For research use only. We do not sell to patients.

Formula: C₁₀H₉N₃O₃
Molecular Weight:219.20

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

UT-B-IN-2 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

mUT-B

0.11 μM (IC₅₀)

rUT-B

0.054 μM (IC₅₀)

In Vitro

UT-B-IN-2 (12f) (0.005-40 μM; 5 min) potently inhibits mouse UT-B with an IC₅₀ of 0.11 μM and rat UT-B with an IC₅₀ of 0.054 μM in an erythrocyte lysis assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_max	C_max	T_1/2	Bioavailability
Rat^[1]	50 mg/kg	p.o.	0.5 h	1690 ng/mL	0.99 h	61.9 %

In Vivo

UT-B-IN-2 (50-100 mg/kg; p.o.; single dose) induces sustained, dose-dependent diuresis in rats, with peak urine output reaching 3-fold to 3.5-fold control levels and duration of action lasting 24 to 40 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male, 170-200 g)^[1]
Dosage:

50 mg/kg; 100 mg/kg
Administration:

p.o.; single dose
Result:

Significantly increased urine output compared to vehicle control, with dose-dependent activity observed.
Showed significant diuresis starting at 16 h post-administration, lasting for 24 h, and urine output peaked at 24-32 h post-administration, reaching 3-fold the control levels (50 mg/kg).
Showed significant diuresis starting at 8 h post-administration, lasting for 40 h, and urine output peaked at 24-32 h post-administration, reaching 3.5-fold the control levels (100 mg/kg).

Chemical Information

Molecular Weight 219.20
Formula C₁₀H₉N₃O₃
SMILES

O=C(C1=CC=C(C(C)=O)O1)NC2=CC=NN2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yao X, et al. 5-Acetyl-N-(1H-pyrazol-5-yl)furan-2-carboxamide as a novel orally available urea transporter inhibitor with improved properties. Eur J Med Chem. 2026 Jun 15;317:119056. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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