1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Unoprostone

Unoprostone 

Cat. No.: HY-106916
Handling Instructions

Unoprostone, a prostaglandin F2α analogs (PGAs), activates BK channels to reduce oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction. Unoprostone reduces intraocular pressure and is used topically for glaucoma or ocular hypertension.

For research use only. We do not sell to patients.

Unoprostone Chemical Structure

Unoprostone Chemical Structure

CAS No. : 120373-36-6

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Description

Unoprostone, a prostaglandin F2α analogs (PGAs), activates BK channels to reduce oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction. Unoprostone reduces intraocular pressure and is used topically for glaucoma or ocular hypertension[1].

In Vitro

Pretreatment with Unoprostone (0.01, 0.1, 1 μM; 1 h before H2O2 treatment) protects against H2O2-induced cell death in a concentration-dependent manner and the effect is significant at 0.1 μM and 1 μM concentrations[1].
Pretreatment with Unoprostone at concentrations of 0.1 to 3 μM protects against light-induced cell death in a concentration-dependent manner; the effect is significant at the 1 and 3 μM concentrations. Unoprostone reduces the morphological change, and it significantly inhibits the low mitochondrial membrane potential and cell death induced by light irradiation[1].
Unoprostone has prostaglandin F receptors (FP) binding affinity with a Ki of 3.86 μM[2].

Cell Viability Assay[1]

Cell Line: H2O2-induced photoreceptor cell
Concentration: 0.01, 0.1, 1 μM
Incubation Time: 1 hour before H2O2 treatment
Result: Protected against H2O2-induced cell death in a concentration-dependent manner.
In Vivo

Unoprostone (0.06%, 0.12%; topical instillation; 3 µl) reduces mouse intraocular pressure (IOP) in a dose-dependent manner[3].

Animal Model: Male mice (6 weeks old)[3]
Dosage: 0.06%, 0.12%
Administration: Topical instillation; 3 µl
Result: Reduced mouse IOP in a dose-dependent manner.
Molecular Weight

382.53

Formula

C₂₂H₃₈O₅

CAS No.

120373-36-6

SMILES

OC(CCC/C=C\C[[email protected]@H]1[[email protected]]([[email protected]](O)C[[email protected]@H]1O)CCC(CCCCCCC)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

UnoprostonePotassium ChannelKcsAprostaglandinF2αanalogsPGAsphagocytoticdysfunctionBKchannelsintraocularpressureglaucomaocularhypertensionInhibitorinhibitorinhibit

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Unoprostone
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