2719675-72-4
Chemical Structure
HIV-1 inhibitor-16
- CAS No.: 2719675-72-4
- Formula:C23H16F2N6
- Molecular Weight:414.41
IUPAC Name: 4-((4-((2,6-difluoro-4-(pyridin-4-yl)phenyl)amino)-5-methylpyrimidin-2-yl)amino)benzonitrile
InChIKey: YKSYOOWFQGGOHN-UHFFFAOYSA-N
SMILES: N#CC1=CC=C(NC2=NC=C(C)C(NC3=C(F)C=C(C4=CC=NC=C4)C=C3F)=N2)C=C1
Biological Activity: HIV-1 inhibitor-16 (compound 7a) is a highly potent HIV-1 inhibitor with an EC50 value of 1.3 nM for HIV-1 WT. HIV-1 inhibitor-16 also has certain inhibitory activity against HIV-1 K103N, E138K, Y181C and L100I strains with EC50s of 5.4 nM, 9.2 nM, 22 nM and 35 nM. HIV-1 inhibitor-16 has favorable solubility and liver microsome stability, and does not exhibit apparent CYP enzymatic inhibitory activity or acute toxicity[1].
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HIV-1 inhibitor-16 | HIV-1 inhibitor-16 (compound 7a) is a highly potent HIV-1 inhibitor with an EC50 value of 1.3 nM for HIV-1 WT. HIV-1 inhibitor-16 also has certain inhibitory activity against HIV-1 K103N, E138K, Y181C and L100I strains with EC50s of 5.4 nM, 9.2 nM, 22 nM and 35 nM. HIV-1 inhibitor-16 has favorable solubility and liver microsome stability, and does not exhibit apparent CYP enzymatic inhibitory activity or acute toxicity. | |||||||||||||||||||||
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Keywords
