Bmp7 - bone morphogenetic protein 7 Gene

Also Known as OP1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12162

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Mutation of this gene results in skeletal, kidney, and Other developmental defects. [provided by RefSeq, Jul 2016]

Bmp7 Products (1)

mRNA Protein Name
NM_007557.3 NP_031583.2 bone morphogenetic protein 7 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12741987 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within BMP signaling pathway IDA
IDA: Inferred from direct assay
14623234 MGI
involved in allantois development IGI
IGI: Inferred from genetic interaction
10079236 MGI
acts upstream of ameloblast differentiation IDA
IDA: Inferred from direct assay
15525533 MGI
acts upstream of or within anatomical structure formation involved in morphogenesis IMP
IMP: Inferred from mutant phenotype
10049573 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
7590254 MGI
acts upstream of or within axon guidance IDA
IDA: Inferred from direct assay
12741987 MGI
acts upstream of or within branching involved in salivary gland morphogenesis IMP
IMP: Inferred from mutant phenotype
11731698 MGI
acts upstream of or within branching morphogenesis of an epithelial tube IDA
IDA: Inferred from direct assay
15831470 MGI
acts upstream of or within camera-type eye morphogenesis IMP
IMP: Inferred from mutant phenotype
16154126 MGI
involved in cardiac muscle tissue development IGI
IGI: Inferred from genetic interaction
10079236 MGI
involved in cardiac septum morphogenesis IGI
IGI: Inferred from genetic interaction
10079236 MGI
acts upstream of or within cell development IDA
IDA: Inferred from direct assay
15831470 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16854970 MGI
involved in chorio-allantoic fusion IGI
IGI: Inferred from genetic interaction
10079236 MGI
acts upstream of or within embryonic camera-type eye morphogenesis IMP
IMP: Inferred from mutant phenotype
10049573 MGI
acts upstream of or within embryonic limb morphogenesis IGI
IGI: Inferred from genetic interaction
9664686 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
9664686 MGI
acts upstream of or within embryonic pattern specification IMP
IMP: Inferred from mutant phenotype
10049573 MGI
acts upstream of or within embryonic skeletal joint morphogenesis IGI
IGI: Inferred from genetic interaction
9664686 MGI
acts upstream of or within embryonic skeletal joint morphogenesis IMP
IMP: Inferred from mutant phenotype
9664686 MGI
involved in endocardial cushion formation IGI
IGI: Inferred from genetic interaction
10079236 MGI
acts upstream of or within epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
17878916 MGI
involved in eye development IMP
IMP: Inferred from mutant phenotype
16154126 MGI
involved in heart trabecula morphogenesis IGI
IGI: Inferred from genetic interaction
10079236 MGI
involved in hindbrain development IGI
IGI: Inferred from genetic interaction
10079236 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
16154126 MGI
involved in kidney development IMP
IMP: Inferred from mutant phenotype
16154126 MGI
acts upstream of mesenchymal cell apoptotic process involved in nephron morphogenesis IMP
IMP: Inferred from mutant phenotype
9056639 MGI
involved in mesenchyme development IMP
IMP: Inferred from mutant phenotype
9693150 MGI
acts upstream of or within mesoderm formation IGI
IGI: Inferred from genetic interaction
15843411 MGI
involved in metanephric mesenchymal cell proliferation involved in metanephros development IGI
IGI: Inferred from genetic interaction
15342483 MGI
involved in metanephric mesenchyme morphogenesis IGI
IGI: Inferred from genetic interaction
15342483 MGI
acts upstream of or within negative regulation of Notch signaling pathway IGI
IGI: Inferred from genetic interaction
16324690 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16854970 MGI
acts upstream of or within negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis IMP
IMP: Inferred from mutant phenotype
9056639 MGI
acts upstream of or within negative regulation of neurogenesis IDA
IDA: Inferred from direct assay
17699604 MGI
acts upstream of or within negative regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
16325379 MGI
acts upstream of or within negative regulation of prostatic bud formation IDA
IDA: Inferred from direct assay
16324690 MGI
involved in nephrogenic mesenchyme morphogenesis IGI
IGI: Inferred from genetic interaction
15342483 MGI
involved in neural fold elevation formation IGI
IGI: Inferred from genetic interaction
10079236 MGI
acts upstream of or within neuron projection morphogenesis IMP
IMP: Inferred from mutant phenotype
16325379 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IDA
IDA: Inferred from direct assay
15525533 MGI
acts upstream of or within pattern specification process IMP
IMP: Inferred from mutant phenotype
7590254 MGI
involved in pericardium morphogenesis IGI
IGI: Inferred from genetic interaction
10079236 MGI
involved in pharyngeal system development IGI
IGI: Inferred from genetic interaction
10079236 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16854970 MGI
involved in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis IGI
IGI: Inferred from genetic interaction
23863481 MGI
acts upstream of or within positive regulation of epithelial cell differentiation IDA
IDA: Inferred from direct assay
15525533 MGI
involved in positive regulation of epithelial to mesenchymal transition IGI
IGI: Inferred from genetic interaction
23863481 MGI
acts upstream of or within positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
9786991 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16801560 MGI
acts upstream of or within regulation of branching involved in prostate gland morphogenesis IMP
IMP: Inferred from mutant phenotype
16324690 MGI
acts upstream of or within salivary gland morphogenesis IMP
IMP: Inferred from mutant phenotype
11731698 MGI
acts upstream of or within tube morphogenesis IDA
IDA: Inferred from direct assay
15831470 MGI
involved in ureteric bud development IMP
IMP: Inferred from mutant phenotype
9693150 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
12741987 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bone morphogenetic protein 7

  • osteogenic protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148234 M4K2234 Inhibitor 98.31% Unkown
HY-173149 CDD-2789 Inhibitor / Unkown
HY-RS01542 BMP7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17049 Bmp7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23493 Bmp7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bmp7 NCBI NCBI:655