BMP7 - bone morphogenetic protein 7 Gene

Also Known as OP-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 655

About BMP7

Cytogenetic location: 20q13.31 Genomic coordinates (GRCh38): 20:57,168,753-57,266,641 (from NCBI)

This gene has 9 transcripts (splice variants), 270 orthologues and 31 paralogues. Biased expression in thyroid (RPKM 30.0), placenta (RPKM 15.8) and 9 other tissues.

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]

BMP7 Products (1)

mRNA	Protein	Name
NM_001719.3	NP_001710.1	bone morphogenetic protein 7 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables BMP receptor binding	IPI IPI: Inferred from physical interaction	18184661	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9872992	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in BMP signaling pathway	IDA IDA: Inferred from direct assay	16049014	GOA
involved in BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	18326817	GOA
involved in cellular response to BMP stimulus	IMP IMP: Inferred from mutant phenotype	18326817	GOA
involved in mesenchymal cell differentiation	IDA IDA: Inferred from direct assay	9693150	GOA
involved in mesonephros development	IEP IEP: Inferred from expression pattern	18437684	GOA
involved in metanephros development	IEP IEP: Inferred from expression pattern	18437684	GOA
involved in monocyte aggregation	IDA IDA: Inferred from direct assay	15100360	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15100360	GOA
involved in negative regulation of cell cycle	IDA IDA: Inferred from direct assay	11502704	GOA
involved in negative regulation of glomerular mesangial cell proliferation	IDA IDA: Inferred from direct assay	17244894	GOA
involved in negative regulation of mitotic nuclear division	IDA IDA: Inferred from direct assay	17244894	GOA
acts upstream of or within negative regulation of neuron differentiation	IDA IDA: Inferred from direct assay	16325379	GOA
acts upstream of or within neuron projection morphogenesis	IDA IDA: Inferred from direct assay	16325379	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14517293	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	27923061	GOA
involved in positive regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	9311995	GOA
involved in positive regulation of bone mineralization	IDA IDA: Inferred from direct assay	18436533	GOA
involved in positive regulation of brown fat cell differentiation	IMP IMP: Inferred from mutant phenotype	27923061	GOA
involved in positive regulation of dendrite development	IDA IDA: Inferred from direct assay	11580864	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	28124060	GOA
involved in positive regulation of heterotypic cell-cell adhesion	IDA IDA: Inferred from direct assay	15100360	GOA
involved in positive regulation of hyaluranon cable assembly	IDA IDA: Inferred from direct assay	15100360	GOA
involved in positive regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	18436533	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in extracellular space	IDA IDA: Inferred from direct assay	17977014	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BMP7 Protein Structure

TGFb_propeptide

TGF_beta

0
100
200
300
400
431 a.a.

Protein Preferred Names	Protein Names
bone morphogenetic protein 7	osteogenic protein 1

BMP7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	BMP7	P18075	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	BMP7	P18075	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	BMP7	P18075	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	32296183
Intra	BMP7	P18075	KRTAP10-9	Homo sapiens	P60411	Validated Y2H	32296183
Intra	BMP7	P18075	KRTAP10-9	Homo sapiens	P60411	Y2H Array	32296183
Intra	BMP7	P18075	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	32296183
Intra	BMP7	P18075	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	BMP7	P18075	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	BMP7	P18075	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	BMP7	P18075	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	BMP7	P18075	KRTAP12-3	Homo sapiens	P60328	Validated Y2H	32296183
Intra	BMP7	P18075	KRTAP9-8	Homo sapiens	Q9BYQ0	Validated Y2H	32296183
Intra	BMP7	P18075	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Array	32296183
Intra	BMP7	P18075	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Prey Pooling	32296183
Intra	BMP7	P18075	CCDC125	Homo sapiens	Q86Z20	Validated Y2H	32296183
Intra	BMP7	P18075	CCDC125	Homo sapiens	Q86Z20	Y2H Prey Pooling	32296183
Intra	BMP7	P18075	CCDC125	Homo sapiens	Q86Z20	Y2H Array	32296183
Intra	BMP7	P18075	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	BMP7	P18075	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	BMP7	P18075	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	BMP7	P18075	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	BMP7	P18075	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
Intra	BMP7	P18075	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	BMP7	P18075	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	32296183
Intra	BMP7	P18075	TRIM27	Homo sapiens	P14373	Y2H Array	31515488
Intra	BMP7	P18075	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	BMP7	P18075	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	BMP7	P18075	BEGAIN	Homo sapiens	Q9BUH8	Y2H Prey Pooling	32296183
Intra	BMP7	P18075	BEGAIN	Homo sapiens	Q9BUH8	Validated Y2H	32296183
Intra	BMP7	P18075	BEGAIN	Homo sapiens	Q9BUH8	Y2H Array	32296183
Intra	BMP7	P18075	KHDRBS2	Homo sapiens	Q5VWX1	Validated Y2H	32296183
Intra	BMP7	P18075	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Prey Pooling	32296183
Intra	BMP7	P18075	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	32296183
Intra	BMP7	P18075	KRTAP3-1	Homo sapiens	Q9BYR8	Validated Y2H	32296183
Intra	BMP7	P18075	KRTAP3-1	Homo sapiens	Q9BYR8	Y2H Array	32296183
Intra	BMP7	P18075	KRTAP3-1	Homo sapiens	Q9BYR8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BMP7 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P7008	BMP-7 Protein, Human	P18075 (S293-H431)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7008A	BMP-7 Protein, Human (His)	P18075 (S293-H431)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700030AF	Animal-Free BMP-7 Protein, Human (His)	P18075 (M315-H431)	≥ 95%, as determined by reducing SDS-PAGE.

BMP7 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P810851	BMP7 Antibody	WB, IHC-P	Human, Mouse, Rat
HY-P82810	BMP7 Antibody (YA2555)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Congenital Heart Defects, Multiple Types, 4	CHTD4 Complete Atrioventricular Septal Defect-Tetralogy Of Fallot Cavc-Tetralogy Of Fallot Complete Avsd-Tetralogy Of Fallot Complete Atrioventricular Canal Defect-Tetralogy Of Fallot Complete Atrioventricular Septal Defect With Ventricular Hypoplasia Cavc With Ventricular Hypoplasia Complete Avsd With Ventricular Hypoplasia Complete Atrioventricular Canal Defect With Ventricular Hypoplasia Complete Atrioventricular Septal Defect With Ventricular Imbalance Unbalanced Complete Atrioventricular Canal Heart Defects, Congenital, Multiple Types, Type 4
Ventricular Septal Defect 1	VSD1
Renal Fibrosis
Ureteral Obstruction
Spondylolisthesis	Slipped Vertebrae Acquired Spondylolisthesis
Spondylolysis	Acquired Spondylolysis
Osteochondritis Dissecans	Osteochondritis Ocd Konig Disease
Tactile Agnosia
Osteonecrosis	Bone Necrosis Avascular Necrosis Of Bone Aseptic Necrosis Necrosis Of Bone Nos Aseptic Osteonecrosis Aseptic Necrosis Of Bone, Site Unspecified Aseptic Or Avascular Bone Necrosis Aseptic Necrosis Of Bone Necrotic Bone Necrotizing Bone Spontaneous Osteonecrosis Osteoradionecrosis
Osseous Heteroplasia, Progressive	Progressive Osseous Heteroplasia POH Osteoma Cutis Familial Ectopic Ossification Ectopic Ossification Familial Type Ectopic Ossification Heterotopic Ossification Ectopic Ossification, Familial Cutaneous Ossification Myositis Ossificans Progressiva Osteodermia Osteosis Cutis Ossification Heterotopic Heteroplasia, Osseous, Progressive Fibrodysplasia Ossificans Progressiva
Secondary Hyperparathyroidism	Hyperparathyroidism Secondary Hyperparathyroidism, Secondary Secondary Hyperparathyroidism Nec
Bone Disease	Bone Diseases Skeletal Disease Skeletal Disorder Disorder Of Skeletal System
Nephrosclerosis	Renal Sclerosis
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Spinal Stenosis	Lumbar Spinal Stenosis Cervical Spinal Stenosis Spinal Stenosis Of Lumbar Region Spinal Stenosis In Cervical Region Spinal Canal Stenosis
Hypospadias	Hypospadias Familial Familial Hypospadias
Sexual Masochism	Masochism
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Hypertension, Pulmonary, Primary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Cardiomyopathy, Familial Restrictive, 3	RCM3 Restrictive Cardiomyopathy 3 Familial Restrictive Cardiomyopathy 3 Cardiomyopathy, Familial Restrictive 3 Cardiomyopathy, Restrictive, Familial, Type 3
Arthropathy	Ankylosis Of Ankle And Foot Joint Ankylosis Of Forearm Joint Ankylosis Of Hand Joint Ankylosis Of Joint Of Ankle And/Or Foot Ankylosis Of Joint Of Forearm Ankylosis Of Joint Of Hand Ankylosis Of Joint Of Lower Leg Ankylosis Of Joint Of Multiple Sites Ankylosis Of Joint Of Pelvic Region And Thigh Ankylosis Of Joint Of Shoulder Region Ankylosis Of Joint Of Upper Arm Ankylosis Of Lower Leg Joint Ankylosis Of Multiple Joints Ankylosis Of Upper Arm Joint Infectious Arthropathy Joint Ankylosis Of The Ankle And Foot Joint Ankylosis Of The Ankle And/Or Foot Joint Ankylosis Of The Forearm Joint Ankylosis Of The Hand Joint Ankylosis Of The Lower Leg Joint Ankylosis Of The Pelvic Region And Thigh Joint Ankylosis Of The Shoulder Region Joint Ankylosis Of The Upper Arm Joint Diseases Joint Disease Arthropathy Associated With Infection
Ureteral Disease	Ureteral Diseases Ureteral Disorders Disorder Of Ureter
Proximal Symphalangism	Cushing'S Symphalangism Symphalangism, Proximal Hereditary Absence Of Proximal Interphalangeal Joints Strasburger-Hawkins-Eldridge Syndrome Strasburger-Hawkins-Eldridge-Hargrave-Mckusick Syndrome Symphalangism, Proximal, 1a Symphalangism, Proximal, 1b Vessel'S Syndrome Symphalangism, Cushing Type
Fibrodysplasia Ossificans Progressiva	Myositis Ossificans Progressiva Progressive Myositis Ossificans FOP Progressive Ossifying Myositis Myositis Ossificans Stone Man Syndrome Man Of Stone Myositis Ossificans Progressive Diffuse Progressive Ossifying Polymyositis Fibrodysplasia Ossificans Congenita Myositis Ossificans Progressiva, Site Unspecified Münchmeyer Disease Fop - [Fibrodysplasia Ossificans Progressiva] Progressive Myositis Ossificans Calcification
Diffuse Pulmonary Fibrosis
Tarsal-Carpal Coalition Syndrome	TCC Tarsal Carpal Coalition Syndrome Nog-Related-Symphalangism Spectrum Disorder
Synostoses, Tarsal, Carpal, And Digital	Calcaneonavicular Coalition Multiple Synostosis Syndrome Synostoses, Tarsal, Carpal And Digital
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Dental Pulp Necrosis	Pulp Necrosis Necrotic Pulp Necrosis Of The Pulp Dead Pulp Devitalised Pulp Putrescent Pulpitis Devitalized Tooth Dental Pulp Gangrene Pulp Gangrene Nonvital Tooth Pulpless Tooth Putrescent Pulp
Urinary Tract Obstruction	Obstructive Uropathy Urinary Obstruction Urologic Diseases
Endocardial Fibroelastosis	Endomyocardial Fibroelastosis Elastomyofibrosis EFE Efe - [Endocardial Fibroelastosis] Primary Endocardial Fibroelastosis Fibroelastosis Cordis Fetal Endocarditis Fibroelastosis Congenital Endocardial Fibroelastosis Congenital Valvular Endocarditis
Ischemic Bone Disease
Bone Deterioration Disease
Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse	PPKNEFD Focal Or Diffuse Nonepidermolytic Palmoplantar Keratoderma Autosomal Dominant Focal Non-Epidermolytic Palmoplantar Keratoderma With Plantar Blistering Palmoplantar Keratoderma, Non-Epidermolytic, Focal Or Diffuse Nonepidermolytic Focal Or Diffuse Palmoplantar Keratoderma Keratoderma, Palmoplantar, Nonepidermolytic, Focal Or Diffuse
Dental Pulp Disease	Dental Pulp Diseases Dental Pulp Disorder Disorder Of Pulp Of Tooth Pulp Disorder
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Anus, Imperforate	Imperforate Anus Anorectal Malformation Anal Atresia Anorectal Malformations Congenital Atresia Of Anus Congenital Or Infantile Occlusion Of Anus Anal Stenosis Arm
Diabetes Mellitus	Diabetes
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Bone Structure Disease
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Thyroid Gland Anaplastic Carcinoma	Anaplastic Thyroid Carcinoma Anaplastic Thyroid Cancer Thyroid Cancer, Anaplastic Thyroid Carcinoma, Anaplastic Thyroid Carcinoma Anaplastic
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Geotrichosis
Coloboma Of Macula	Coloboma Congenital Ocular Coloboma Microphthalmia, Isolated, With Coloboma Agenesis Of Macula Hereditary Macular Coloboma Ocular Coloboma Coloboma Of Eye Macular Coloboma Uveoretinal Coloboma
Uruguay Faciocardiomusculoskeletal Syndrome	FCMSU Faciocardiomusculoskeletal Syndrome, Uruguay Type Fcms Musculoskeletal Diseases
Alport Syndrome	Hereditary Nephritis Alport Syndrome, X-Linked Hemorrhagic Hereditary Nephritis Congenital Hereditary Hematuria Hemorrhagic Familial Nephritis Familial Nephritis Thin Basement Membrane Disease Thin Basement Membrane Nephropathy Hematuria-Nephropathy-Deafness Syndrome Hematuric Hereditary Nephritis Hereditary Familial Congenital Hemorrhagic Nephritis Hereditary Hematuria Syndrome Hereditary Interstitial Pyelonephritis Alport Deafness-Nephropathy Alport Hearing Loss-Nephropathy Alports Syndrome Nephritis, Hereditary
Hereditary Hemorrhagic Telangiectasia	Rendu-Osler-Weber Disease Hht Osler-Weber-Rendu Disease Telangiectasia, Hereditary Hemorrhagic Osler Hemorrhagic Telangiectasia Syndrome Orw Disease Osler Weber Rendu Syndrome Osler-Rendu-Weber Disease Osler-Weber-Rendu Syndrome Rendu-Osler Disease Telangiectasia Hereditary Hemorrhagic Telangiectasia Hemorrhagic, Hereditary Hht - [Hereditary Haemorrhagic Telangiectasia] Osler Haemorrhagic Telangiectasia Syndrome
Orofacial Cleft	Cleft, Orofacial
Cakut	Renal Or Urinary Tract Malformation Congenital Anomalies Of Kidney And Urinary Tract Congenital Anomaly Of Kidney And Urinary Tract Congenital Anomalies Of The Kidney And Urinary Tract Kidney And Urinary Tract, Anomalies, Congenital Renal Hypodysplasia, Nonsyndromic, 1
Chromosome 2q35 Duplication Syndrome	Syndactyly Syndactyly Type 1 Sdty1 Zygodactyly Syndactyly, Type I Sd1 Syndactyly, Type 1, With Or Without Craniosynostosis Symphalangism Non-Syndromic Syndactyly Symphalangy Webbing Of Digits Syndactyly, Type 1
Brittle Bone Disorder	Osteogenesis Imperfecta Brittle Bone Disease Fragilitas Ossium Osteopsathyrosis Lobstein Disease Oi Vrolik Disease Lobstein'S Disease Lobstein'S Syndrome Vrolik'S Disease Porak And Durante Disease Glass Bone Disease Osteogenesis Imperfecta, Dominant Perinatal Lethal Osteogenesis Imperfecta, Recessive Perinatal Lethal Brittle Bone Syndrome Oi - [Osteogenesis Imperfecta] Ossium Fragility Osteitis Fragilitans Bony Fragility Blue Sclera With Fragility Of Bone And Deafness White Blue Sclera - Fragility Of Bone - Deafness
Osteochondrodysplasia	Skeletal Dysplasia Chondrodystrophy Congenital Anomaly Of Cartilage Osteochondrodysplasias Cartilage Development Disorder Osteochondrodysplasia Syndrome Dysplasia, Skeletal Mucopolysaccharidosis Iv
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-148234	M4K2234	Inhibitor	98.31%	Unkown
HY-173149	CDD-2789	Inhibitor	/	Unkown
HY-RS01542	BMP7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17049	Bmp7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23493	Bmp7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BMP7	MGD	MGI:103302
Macaca mulatta	BMP7	VGNC	VGNC:70266
Felis catus	BMP7	VGNC	VGNC:60135
Bos taurus	BMP7	VGNC	VGNC:26522
Rattus norvegicus	BMP7	RGD	RGD:620743
Canis familiaris	BMP7	VGNC	VGNC:38482
Others	BMP7	NCBI