BMP7 Antibody
(Synonyms: OP1, BMP7, Bone morphogenetic protein 7, BMP-7, Osteogenic protein 1, OP-1)BMP7 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to BMP7.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
BMP7 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to BMP7.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 55 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 49 kDa
Synthetic peptide corresponding to the center region of human BMP7.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
BMP7 is a Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, also uses BMPR2 as type II receptor. Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors. Promotes the expression of HAMP, this is repressed by its interaction with ERFE[1][2][3][4][5][6].
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Subcellular Localization
Secreted
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Expression
Tissue_Specificity: Expressed in the kidney and bladder. Lower levels seen in the brain. -
Isoforms & Post-Translational Modification
BMP7 has an amino acid length of 431, molecular weight is 49313 Da.通过直接测序已鉴定到多个起始于 293、300、315 和 316 位的 N 端，可分泌产生不同的成熟形式BMP7 的氨基酸个数为 431 个，分子量为 49313 Da。Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms
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Subunit
Homodimer; disulfide-linked.
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SwissProt ID
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Synonyms
OP1, BMP7, Bone morphogenetic protein 7, BMP-7, Osteogenic protein 1, OP-1
Documentation
[1]. Perron JC, et al. Chemotropic signaling by BMP7 requires selective interaction at a key residue in ActRIIA. Biol Open. 2019 Jul 16;8(7):. [Content Brief]
[2]. Greenwald J, et al. The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly. Mol Cell. 2003 Mar;11(3):605-17. [Content Brief]
[3]. Macías-Silva M, et al. Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. J Biol Chem. 1998 Oct 2;273(40):25628-36. [Content Brief]
[4]. Groppe J, et al. Structural basis of BMP signalling inhibition by the cystine knot protein Noggin. Nature. 2002 Dec 12;420(6916):636-42. [Content Brief]
[5]. Brunmeir R, et al. Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis. PLoS Genet. 2016 Dec;12(12):e1006474. [Content Brief]
[6]. Arezes J, et al. Erythroferrone inhibits the induction of hepcidin by BMP6. Blood. 2018 Oct 4;132(14):1473-1477. [Content Brief]
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