STH - saitohin Gene

Also Known as MAPTIT

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 246744

About STH

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:45,999,250-45,999,694 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele and 2 orthologues.

Summary

Involved in positive regulation of mRNA splicing, via spliceosome. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

STH Products (1)

mRNA	Protein	Name
NM_001007532.3	NP_001007533.1	saitohin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16186110	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of mRNA splicing, via spliceosome	IGI IGI: Inferred from genetic interaction	16186110	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16186110	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16186110	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16186110	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
saitohin	microtubule-associated protein tau (MAPT) intronic transcript

STH Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STH	Q8IWL8	TFG	Homo sapiens	Q92734	Validated Y2H	32296183
Intra	STH	Q8IWL8	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	32296183
Intra	STH	Q8IWL8	PEF1	Homo sapiens	Q9UBV8	Validated Y2H	32296183
Intra	STH	Q8IWL8	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	STH	Q8IWL8	CSTF2T	Homo sapiens	Q9H0L4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ascaris Lumbricoides Infection	Ascariasis Ascaris Lumbricoides Infection, Susceptibility To Ascariasis, Susceptibility To Ascariasis - Roundworm Infection Due To Ascaris Lumbricoides Ascaridiasis Roundworm Infection Ascaridia Ascaridiosis Ascaridosis Ascariosis Ascaris Ascaris Lumbricoides Infestation Ascaris Infection Infection By Ascaridia
Dracunculiasis	Guinea Worm Disease Dracontiasis Dracunculosis Infection By Dracunculus Medinensis Gwd Guinea Worm Infection Parasitic Infection Caused By Dracunculus Medinensis Medina Worm Disease Medinensis Medina Worm Infestation Dracunculus Medinensis Infestation Guinea Worm Infestation
Filarial Elephantiasis	Lymphatic Filariasis Elephantiasis Filariasis Bancroftian Elephantiasis Bancroftian Filarial Chyluria Elephantiasis Of Eyelid Bancroftian Filariasis Elephantitis Malayi Tropical Eosinphilia Wuchereria Bancrofti Infection Wuchereriasis Elephantiasis, Filarial Filarial Elephantiases Infection By Wuchereria Bancrofti Filarial Lymphangitis Tropical Elephantiasis Filarial Chylocele
Acidophil Adenoma	Adenoma, Acidophil Eosinophil Adenoma
Enterobiasis	Oxyuriasis Pinworm Infection Enterobius Vermicularis Infection Threadworm Infection Oxyuris Vermicularis Infection Enterobiosis Pinworm Pinworm Disease Seatworm Infection Enterobiasis Threadworm Pinworm Infestation Seatworm
Loiasis	Loa Loa Filariasis Mansonelliasis African Eye Worm Mansonella Perstans Infections Mansonellosis Eye Worm Disease Of Africa Loa Loa Infestation African Eyeworm Disease Calabar Swelling
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Taeniasis	Beef Tapeworm Infection Infection By Taeniarhynchus Saginatus Taenia Saginata Infectious Disease Taenia Saginata Infection Pork Tapeworm Infection Armed Tapeworm Infection Infection By Taenia Solium Intestinal Taenia Solium Infection Pork Tapeworm Taenia Solium Taeniasis Adult Pork Tapeworm Infection Adult Pork Tapeworm Beef Tapeworm Infection By Taenia Saginata Unarmed Tapeworm Infection Taenia Saginata Taeniasis Infection Due To Adult Tapeworm Taenia Saginata Mediocanellata Taenia Infection Infestation By Taenia Saginata Infestation By Taenia Mediocanellata
Elephantiasis
Parasitic Helminthiasis Infectious Disease	Helminthiasis Intestinal Helminthiasis Helminth Infection Helminthosis Worm Infection Worm Infections Helminth Infections Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata Parasitic Enteritis Metazoal Dysentery Intestinal Worms Nos
Yaws	Frambesia Frambesia Tropica Bouba Frambosie Polypapilloma Tropicum Thymosis Endemic Treponematoses Treponema Pertenue Infection Pian Framboesia Framboesia Tropica Castellani Infection By Treponema Pertenue Parangi Framboesioma Chancre Of Yaws Primary Framboesia Initial Lesions Of Yaws Mother Yaw Initial Framboesia
Urinary Schistosomiasis	Schistosoma Haematobium Infection Schistosoma Hematobium Infection Schistosomiasis Due To Schistosoma Haematobium Bladder Schistosomiasis Cystitis With Bilharziasis Schistosoma Haematobium Schistosoma Hematobium Infectious Disease Schistosomiasis Of Bladder Vesical Schistosomiasis Schistosomiasis Urinary Schistosomiasis Haematobia Genitourinary Bilharziasis Genitourinary Tract Schistosomiasis Schistosomiasis Due To Schistosoma Haematobium [Urinary Schistosomiasis] Haematochyluria In Schistosomiasis Infection Due To Schistosoma Matthei
Podoconiosis	PDCOS Podoconiosis, Susceptibility To Nonfilarial Elephantiasis Of Lower Legs Nonfilarial Elephantiasis Of Lower Legs, Susceptibility To Endemic Nonfilarial Elephantiasis Endemic Nonfilarial Elephantiasis, Susceptibility To Lymphostatic Verrucosis Lymphostatic Verrucosis, Susceptibility To Elephantiasis Endemic Non-Filarial Elephantiasis
Trichuriasis	Whipworm Infection Whipworm Disease Trichocephaliasis Infection By Trichuris Trichura Trichuriasis Infection Trichuris Trichiura Infection Infection By Trichuris Trichiura Trichocephalosis Infection By Trichocephalus Trichiura Infection By Trichuris Infection By Trichuris Trichiuria Trichuriosis Whipworm Infection Due To Trichuris Trichiura Trichocephalus Infestation Trichuris Infestation Whipworm Infestation
Hymenolepiasis	Dwarf Tapeworm Infection Hymenolepis Infectious Disease Hymenolepsis Infection Hyemolepis Nana Infection Hymenolepiosis Hymenolepis Infection Dwarf Tapeworm Hymenolepidosis Hymenolepis Infestation
Chromophobe Adenoma	Adenoma, Chromophobe Chromophobe Adenoma Of The Pituitary Gland Adenoma Chromophobe
Chromosome 17q21.31 Duplication Syndrome	17q21.31 Microduplication Syndrome Trisomy 17q21.31 Dup(17)(Q21.31)
Intestinal Schistosomiasis	Schistosomiasis Japonica Schistosomiasis Mansoni Katayama Fever Schistosoma Japonicum Infection Schistosoma Mansoni Infectious Disease Schistosomiasis
Gnathomiasis	Gnathostomiasis Infectious Disease By Gnathostoma Gnathostomosis Wandering Swelling
Trachoma	Trachoma Dubium Active Stage Trachoma Trachoma, Active Stage Trachoma, Initial Stage Egyptian Ophthalmia Trachoma Pannus Marginal Corneal Pannus Trachomatous Pannus
Strongyloidiasis	Disseminated Strongyloidiasis Anguilluliasis Anguillulosis Infection By Strongyloides Threadworm Infection Enterobiasis
Ascaridiasis	Ascariasis
Dysbaric Osteonecrosis	Caisson Disease Of Bone Don
Onchocerciasis	Infection By Onchocerca Volvulus River Blindness Onchocerca Volvulus Infection Volvulosis Robles' Disease Onchocerciasis, Ocular Robles Disease Onchocercosis Blinding Filariasis Robles Onchocerca Infestation Craw-Craw
Scabies	Sarcoptic Itch Infestation By Sarcoptes Scabiei Infestation By Sarcoptes Scabiei Var Hominis Infestation By Sarcoptes Scabiei Var. Hominis
Paragonimiasis	Infection By Paragonimus Lung Fluke Disease Lung Fluke Infection Pulmonary Paragonimiasis Paragonimus Westermani Infection Pulmonary Distomiasis Parasitic Haemoptysis Oriental Lung Fluke Disease Endemic Haemoptysis Paragonimosis Pulmonary Distomatosis Lung Fluke Disorder Infestation By Paragonimus Infection Due To Paragonimus Species Infestation Due To Paragonimus Species Oriental Lung Fluke Infestation Endemic Oriental Haemoptysis
Mite Infestation	Mite Infestations Acariasis Infestation By Mites Nos
Toxocariasis	Toxocara Infection Visceral Larva Migrans Larva Migrans, Visceral Infection By Toxascaris Larva Migrans Visceral Larva Migrans Visceralis Toxocaral Visceral Larva Migrans Visceral Larva Migrans Syndrome Toxocara Infestation
Koolen-De Vries Syndrome	KDVS 17q21.31 Microdeletion Syndrome Microdeletion 17q21.31 Syndrome Chromosome 17q21.31 Deletion Syndrome Koolen De Vries Syndrome Kansl1-Related Intellectual Disability Syndrome Chromosome 17q21.31 Microdeletion Syndrome Monosomy 17q21.31 17q21.31 Deletion Syndrome Koolen Syndrome Del(17)(Q21.31)
Filariasis	Disease Due To Superfamily Filarioidea Bancroftian Filarial Fever Mumu Wanganga Bancroftian Filariasis Wuchereriosis Brugiosis Malayan Filariasis
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Clonorchiasis	Oriental Liver Fluke Disease Clonorchis Liver Infection Clonorchiosis Chinese Liver Fluke Disease Hepatic Distomiasis Due To Clonorchis Sinensis Infection Due To Clonorchis Sinensis Hepatic Distomiasis Hepatic Distomatosis Chinese Liver Fluke Disorder Oriental Liver Fluke Disorder Clonorchis Infestation Chinese Liver Fluke Infestation Liver Fluke Disease Due To Clonorchis Sinensis Oriental Liver Fluke Infestation
Hydrocele	Testicular Hydrocele
Loeffler Syndrome	Loeffler'S Pneumonia Loffler'S Syndrome Simple Pulmonary Eosinophilia
Cysticercosis	Neurocysticercosis Submacular Cysticercosis Intestinal Taenia Solium Infection Pork Tapeworm Infection Tapeworm Infection: Intestinal Taenia Solum Tapeworm Infection: Pork Tenia Solium Infectious Disease Taeniasis Tenia Solium Infection Cysticerciasis Infection Due To Larval Form Of Taenia Solium
Developmental And Epileptic Encephalopathy 24	DEE24 Epileptic Encephalopathy, Early Infantile, 24 Eiee24 Developmental And Epileptic Encephalopathy, 24 Early Infantile Epileptic Encephalopathy 24 Encephalopathy, Epileptic, Early Infantile, Type 24
Gastroduodenal Crohn'S Disease	Upper Gi Crohn'S Disease
Giardiasis	Beaver Feaver Infection By Giardia Lamblia Lambliasis Giardia Lamblia Dysentery Giardial Diarrhoea Lamblia Dysentery Giardia Duodenalis Dysentery Giardia Intestinalis Dysentery
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Dysentery	Infectious Diarrhea
Acute Diarrhea
Parasitic Ectoparasitic Infectious Disease	Ectoparasitic Infestations Ectoparasitism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13911	STH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown