GBP2 - guanylate binding protein 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2634

About GBP2

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:89,106,132-89,126,114 (from NCBI)

This gene has 4 transcripts (splice variants), 144 orthologues and 10 paralogues. Ubiquitous expression in appendix (RPKM 36.9), urinary bladder (RPKM 31.7) and 24 other tissues.

Summary

This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013]

GBP2 Products (1)

mRNA Protein Name
NM_004120.5 NP_004111.2 guanylate-binding protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
31091448 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
21151871 GOA
enables molecular function inhibitor activity IDA
IDA: Inferred from direct assay
31091448 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18985028 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
21151871 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
17266443 GOA
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
17266443 GOA
involved in cellular response to type II interferon IDA
IDA: Inferred from direct assay
17266443 GOA
involved in defense response to virus IDA
IDA: Inferred from direct assay
31091448 GOA
involved in protein localization to nucleus IDA
IDA: Inferred from direct assay
21151871 GOA
Cellular Component GO Annotation Evidence References Source
is active in Golgi apparatus IDA
IDA: Inferred from direct assay
31091448 GOA
located in Golgi apparatus IDA
IDA: Inferred from direct assay
17266443 GOA
is active in Golgi membrane IDA
IDA: Inferred from direct assay
31091448 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
21151871 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17266443 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17266443 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GBP2 Protein Structure

GBP

GBP: Guanylate-binding protein, N-terminal domain (19 - 280)

GBP_C

GBP_C: Guanylate-binding protein, C-terminal domain (282 - 578)

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  • 400
  • 500
  • 591 a.a.
Protein Preferred Names Protein Names

guanylate-binding protein 2

  • GTP-binding protein 2

GBP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GBP2 P32456 GBP4 Homo sapiens Q96PP9
Anti Tag CoIP
21151871
Intra
GBP2 P32456 GBP4 Homo sapiens Q96PP9
BiFC
21151871
Intra
GBP2 P32456 GBP3 Homo sapiens Q9H0R5
Anti Tag CoIP
28514442
Intra
GBP2 P32456 GBP3 Homo sapiens Q9H0R5
Anti Tag CoIP
21151871
Intra
GBP2 P32456 GBP3 Homo sapiens Q9H0R5
BiFC
21151871
Intra
GBP2 P32456 GBP3 Homo sapiens Q9H0R5
Anti Tag CoIP
33961781
Intra
GBP2 P32456 GBP1 Homo sapiens P32455
Anti Tag CoIP
21151871
Intra
GBP2 P32456 GBP1 Homo sapiens P32455
BiFC
21151871
Intra
GBP2 P32456 GBP7 Homo sapiens Q8N8V2
Anti Tag CoIP
33961781
Intra
GBP2 P32456 GBP2 Homo sapiens P32456
Y2H
21151871
Intra
GBP2 P32456 GBP2 Homo sapiens P32456
Anti Tag CoIP
21151871
Intra
GBP2 P32456 GBP7 Homo sapiens Q8N8V2
Anti Tag CoIP
28514442
Intra
GBP2 P32456 GBP2 Homo sapiens P32456
BiFC
21151871
Intra
GBP2 P32456 HSP90AA5P Homo sapiens Q58FG0
Anti Tag CoIP
33961781
Intra
GBP2 P32456 HSP90AA5P Homo sapiens Q58FG0
Anti Tag CoIP
28514442
Intra
GBP2 P32456 GBP5 Homo sapiens Q96PP8
BiFC
21151871
Intra
GBP2 P32456 GBP5 Homo sapiens Q96PP8
Anti Tag CoIP
21151871
Cross
GBP2 P32456 Q9WMX2-PRO_0000037548 Hepatitis C virus Q9WMX2-PRO_0000037548
Pull Down
18985028
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GBP2 Proteins

Cat. No. Product Name Accession Purity
HY-P75787 GBP2 Protein, Human (HEK293, His) AAH73163.1 (M1-C588) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05308 GBP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17953 Gbp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24424 Gbp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GBP2 RGD RGD:621810
Others GBP2 NCBI