GBP2 Protein, Human (HEK293, His)
Based on 1 Customer Validation
CBP2 is an interferon-induced guanylate-binding protein. GBP2 plays an important role in regulating cell proliferation and resisting pathogen infection. p53 can up-regulate GBP2 and play an important role in tumor development by inhibiting metalloproteinases MM9, NF-Kappa B and Rac proteins. GBP2 Protein, Human (HEK293, His) is the recombinant human-derived GBP2 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
CBP2 is an interferon-induced guanylate-binding protein. GBP2 plays an important role in regulating cell proliferation and resisting pathogen infection. p53 can up-regulate GBP2 and play an important role in tumor development by inhibiting metalloproteinases MM9, NF-Kappa B and Rac proteins. GBP2 Protein, Human (HEK293, His) is the recombinant human-derived GBP2 protein, expressed by HEK293 , with C-His labeled tag.
Background
Interferon is a cytokine that has an antiviral effect and inhibits the proliferation of tumor cells. They induce a large number of genes in target cells, including genes encoding guanylate binding proteins (GBPs). The mouse GBP2 gene is not only highly activated by interferon-gamma during macrophage activation, but also stimulated by toll-like receptors, tumor necrosis factor (TNF), and interleukin-1β. GBP2 plays an important role in regulating cell proliferation and resisting pathogen infection. p53 regulates GBP2 and plays an important role in tumor development by inhibiting metalloproteinases MM9, NF-Kappa B and Rac proteins[1][2][3].
MCE Validation Data
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Purity - SDS-PAGE
Purity - SDS-PAGE
Technical Parameters
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Species Human
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Source HEK293
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Tag C-10*His
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Accession
AAH73163.1 (M1-C588)
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Molecular Construction
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N-term
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GBP2 (M1-C588)
Accession # AAH73163.1 -
His
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C-term
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Protein Length
Full Length of Guanylate-binding protein 2 Chain
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Synonyms
GBP2; Guanine Nucleotide-Binding Protein 2; Guanylate Binding Protein 2; GTP-Binding Protein 2; Guanylate-Binding Protein 2; GBP2 Protein; Guanylate Binding Protein 2, Interferon-Inducible; HuGBP-2; Interferon-Induced Guanylate-Binding Protein 2; GBP-2
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AA Sequence
MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAILLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTLRDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPAPKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVNAISSGDLPCRENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEEDVKQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQSLSEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQLMAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKSLEPIC
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Molecular Weight
Approximately 62 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (239 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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