GBP2 Protein, Human (HEK293, His)

CBP2 is an interferon-induced guanylate-binding protein. GBP2 plays an important role in regulating cell proliferation and resisting pathogen infection. p53 can up-regulate GBP2 and play an important role in tumor development by inhibiting metalloproteinases MM9, NF-Kappa B and Rac proteins. GBP2 Protein, Human (HEK293, His) is the recombinant human-derived GBP2 protein, expressed by HEK293 , with C-His labeled tag.

Interferon is a cytokine that has an antiviral effect and inhibits the proliferation of tumor cells. They induce a large number of genes in target cells, including genes encoding guanylate binding proteins (GBPs). The mouse GBP2 gene is not only highly activated by interferon-gamma during macrophage activation, but also stimulated by toll-like receptors, tumor necrosis factor (TNF), and interleukin-1β. GBP2 plays an important role in regulating cell proliferation and resisting pathogen infection. p53 regulates GBP2 and plays an important role in tumor development by inhibiting metalloproteinases MM9, NF-Kappa B and Rac proteins^[1][2][3].

Human

HEK293

C-10*His

AAH73163.1 (M1-C588)

2634  [NCBI]

Partial

MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAILLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTLRDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPAPKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVNAISSGDLPCRENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEEDVKQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQSLSEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQLMAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKSLEPIC

Approximately 60-75 kDa due to the glycosylation.

• 
  ≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.