SLAMF1 - signaling lymphocytic activation molecule family member 1 Gene

Also Known as SLAM; CD150; CDw150

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6504

About SLAMF1

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:160,608,106-160,647,044 (from NCBI)

This gene has 3 transcripts (splice variants), 99 orthologues and 9 paralogues. Biased expression in lymph node (RPKM 8.7), appendix (RPKM 6.0) and 11 other tissues.

Summary

Enables SH2 domain binding activity and identical protein binding activity. Involved in several processes, including negative regulation of CD40 signaling pathway; negative regulation of cytokine production; and positive regulation of MAPK cascade. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

SLAMF1 Products (2)

mRNA	Protein	Name
NM_001330754.2	NP_001317683.1	signaling lymphocytic activation molecule isoform a precursor
NM_003037.5	NP_003028.1	signaling lymphocytic activation molecule isoform b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SH2 domain binding	IDA IDA: Inferred from direct assay	9774102	GOA
enables cell adhesion mediator activity	IDA IDA: Inferred from direct assay	10972291	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21217702	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9774102	GOA
enables virus receptor activity	IDA IDA: Inferred from direct assay	10972291	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in myeloid dendritic cell activation involved in immune response	IDA IDA: Inferred from direct assay	16317102	GOA
involved in negative regulation of CD40 signaling pathway	IDA IDA: Inferred from direct assay	16317102	GOA
involved in negative regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	16317102	GOA
involved in negative regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	16317102	GOA
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	16317102	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	20231852	GOA
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	20231852	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	10972291	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLAMF1 Protein Structure

SLAM

0
100
200
300
335 a.a.

Protein Preferred Names	Protein Names
signaling lymphocytic activation molecule	IPO-3

SLAMF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLAMF1	Q13291	SH2D1A	Homo sapiens	O60880-1	Anti Bait CoIP	15841490
Intra	SLAMF1	Q13291	SH2D1A	Homo sapiens	O60880	Y2H	9774102
Intra	SLAMF1	Q13291	SLAMF1	Homo sapiens	Q13291	SPR	21217702
Intra	SLAMF1	Q13291	SH2D1A	Homo sapiens	O60880	FPS	11477068
Intra	SLAMF1	Q13291	SH2D1A	Homo sapiens	O60880	NMR	11823424
Intra	SLAMF1	Q13291	MAP4K1	Homo sapiens	Q92918	Pull Down	20231852
Intra	SLAMF1	Q13291	SH2D1A	Homo sapiens	O60880	X-Ray Diffraction	12545174
Intra	SLAMF1	Q13291	SLAMF1	Homo sapiens	Q13291	Protein Array	21982860
Intra	SLAMF1	Q13291	SH2D1A	Homo sapiens	O60880	Pull Down	20231852

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SLAMF1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7788	CD150/SLAMF1 Protein, Human (HEK293, His)	Q13291-1 (A21-P237)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72413	CD150/SLAMF1 Protein, Human (Biotinylated, HEK293, His-Avi)	Q13291-1 (A21-P237)	≥ 95%, as determined by reducing SDS-PAGE.

SLAMF1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82894	SLAMF1 Antibody (YA2639)	WB, IP, FC	Human

Related Diseases

Diseases	Alias
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Subacute Sclerosing Panencephalitis	SSPE Dawson Encephalitis Immunosuppressive Measles Encephalitis Subacute Sclerosing Leukoencephalitis Panencephalitis, Subacute Sclerosing Subacute Sclerosing Leukoencephalopathy Van Bogaert'S Sclerosing Leukoencephalitis Dawson Disease Subacute Inclusion Body Encephalitis Van Bogaert Disease Van Bogaert Encephalitis Measles Inclusion Body Encephalitis Mibe - [Measles Inclusion Body Encephalitis] Sspe - [Subacute Sclerosing Panencephalitis] Van Bogaert Leukoencephalitis Van Bogaert Sclerosing Leukoencephalitis Dawson Inclusion Body Encephalitis Van Bogaert Sclerosing Leukoencephalopathy Bodechtel Guttman Disease Diffuse Sclerosing Encephalitis
Lymphoproliferative Syndrome	Lymphoproliferative Disorder Lymphoproliferative Disorders Lymphoproliferative Disorders, Susceptibility To
Lymphoproliferative Syndrome, X-Linked, 1	Lymphomatoid Papulosis Duncan Disease Purtilo Syndrome X-Linked Lymphoproliferative Syndrome Xlp X-Linked Lymphoproliferative Disease XLP1 Lyp Lymphoproliferative Disease, X-Linked Xlpd X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency Ebv Infection, Severe, Susceptibility To Ebvs Immunodeficiency 5 Imd5 X-Linked Lymphoproliferative Syndrome 1 Epstein-Barr Virus Infection, Familial Fatal Ebv Infection, Severe Infectious Mononucleosis, Severe Infectious Mononucleosis, Severe, Susceptibility To Immunodeficiency, X-Linked Progressive Combined Variable Epstein Barr Virus Infection, Familial Fatal X-Linked Progressive Combined Variable Immunodeficiency 5 Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males Familial Fatal Epstein-Barr Infection Severe Susceptibility To Ebv Infection Severe Susceptibility To Infectious Mononucleosis Sap Deficiency Sh2d1a/Slam-Associated Protein Deficiency X-Linked Lymphoproliferative Syndrome Type 1 X-Linked Progressive Combined Variable Immunodeficiency Lymphoproliferative Syndrome, X-Linked Sap X-Linked Lymphoproliferative Disorder
Selective Immunoglobulin Deficiency Disease
Dysgammaglobulinemia
Lymphoproliferative Syndrome, X-Linked, 2	XLP2 Xiap Deficiency X-Linked Lymphoproliferative Syndrome 2 X-Linked Lymphoproliferative Disease Due To Xiap Deficiency Xiap-Related Lymphoproliferative Disease, X-Linked X-Linked Lymphoproliferative Syndrome Type 2 Xiap Deficiency Syndrome
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Trochlear Nerve Disease	Trochlear Nerve Diseases Disorder Of Trochlear Nerve Superior Oblique Muscle Innervation Disorder Trochlear Nerve Disorder Fourth Cranial Nerve Paresis
Lymphoproliferative Syndrome 2	Cd27 Deficiency LPFS2 Combined Immunodeficiency Due To Cd27 Deficiency Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Herpangina	Vesicular Pharyngitis
Pfeiffer Syndrome	Infectious Mononucleosis Acs5 Craniofacial-Skeletal-Dermatologic Dysplasia Acs V Noack Syndrome Gammaherpesviral Mononucleosis Acrocephalosyndactyly Type 5 Pfeiffer Syndrome Type 3 Acrocephalosyndactyly, Type V Glandular Fever Pfeiffer Type Acrocephalosyndactyly Pfeiffer Syndrome Type 2 Acrocephalosyndactylia Type V Filatov'S Disease Monocytic Angina Mononucleosis Pfeiffer'S Disease Acsv Acrocephalosyndactyly, Type 5 Craniofacial-Skeletal-Dermatologic Syndrome Pfeiffer Syndrome Type 1 Classic Pfeiffer Syndrome PS Pfeiffer Syndrome Variant Dysplasia, Craniofacial-Skeletal-Dermatologic Pfeiffer Kissing Disease Infectious Adenitis Pfeiffer Disease
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified
Hemophagocytic Lymphohistiocytosis	Lymphohistiocytosis, Hemophagocytic Haemophagocytic Syndrome Lymphohistiocytosis Hemophagocytic Hemophagocytic Syndrome Familial Hemophagocytic Lymphocytosis Histiocytoses Of Mononuclear Phagocytes Haemophagocytic Lymphohistiocytosis Nos
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12979	SLAMF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17619	Slamf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24079	Slamf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLAMF1	VGNC	VGNC:34653
Canis familiaris	SLAMF1	VGNC	VGNC:46206
Mus musculus	SLAMF1	MGD	MGI:1351314
Macaca mulatta	SLAMF1	VGNC	VGNC:77378
Rattus norvegicus	SLAMF1	RGD	RGD:1560634
Felis catus	SLAMF1	VGNC	VGNC:65177
Others	SLAMF1	NCBI