SLIT2 - slit guidance ligand 2 Gene

Also Known as SLIL3; Slit-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9353

About SLIT2

Cytogenetic location: 4p15.31 Genomic coordinates (GRCh38): 4:20,251,905-20,620,561 (from NCBI)

This gene has 12 transcripts (splice variants), 195 orthologues and 25 paralogues. Broad expression in lung (RPKM 13.1), adrenal (RPKM 9.9) and 21 other tissues.

Summary

This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during Other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as Other specific processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

SLIT2 Products (3)

mRNA Protein Name
NM_001289135.3 NP_001276064.1 slit homolog 2 protein isoform 2 precursor
NM_001289136.3 NP_001276065.1 slit homolog 2 protein isoform 3 precursor
NM_004787.4 NP_004778.1 slit homolog 2 protein isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase inhibitor activity IDA
IDA: Inferred from direct assay
16439689 GOA
enables Roundabout binding IPI
IPI: Inferred from physical interaction
10102268 GOA
enables heparin binding IDA
IDA: Inferred from direct assay
17062560 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
19498462 GOA
enables laminin-1 binding IDA
IDA: Inferred from direct assay
10102268 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10102268 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
19498462 GOA
enables proteoglycan binding IPI
IPI: Inferred from physical interaction
11375980 GOA
Biological Process GO Annotation Evidence References Source
involved in Roundabout signaling pathway IMP
IMP: Inferred from mutant phenotype
18829537 GOA
involved in apoptotic process involved in luteolysis IEP
IEP: Inferred from expression pattern
18566128 GOA
involved in axon extension involved in axon guidance IDA
IDA: Inferred from direct assay
16840550 GOA
involved in axon guidance IDA
IDA: Inferred from direct assay
11748139 GOA
involved in branching morphogenesis of an epithelial tube IDA
IDA: Inferred from direct assay
18345009 GOA
involved in branching morphogenesis of an epithelial tube IMP
IMP: Inferred from mutant phenotype
19005219 GOA
involved in cell migration involved in sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
19351956 GOA
involved in cellular response to heparin IDA
IDA: Inferred from direct assay
17062560 GOA
involved in cellular response to hormone stimulus IEP
IEP: Inferred from expression pattern
18566128 GOA
NOT involved in chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration IDA
IDA: Inferred from direct assay
11748139 GOA
involved in chemorepulsion involved in postnatal olfactory bulb interneuron migration IDA
IDA: Inferred from direct assay
15207848 GOA
involved in corticospinal neuron axon guidance through spinal cord IMP
IMP: Inferred from mutant phenotype
10975526 GOA
involved in induction of negative chemotaxis IDA
IDA: Inferred from direct assay
10197527 GOA
involved in motor neuron axon guidance IDA
IDA: Inferred from direct assay
10102268 GOA
involved in negative chemotaxis IDA
IDA: Inferred from direct assay
11748139 GOA
involved in negative chemotaxis IMP
IMP: Inferred from mutant phenotype
19005219 GOA
involved in negative regulation of actin filament polymerization IDA
IDA: Inferred from direct assay
19759280 GOA
involved in negative regulation of cell growth IMP
IMP: Inferred from mutant phenotype
18829537 GOA
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
19005219 GOA
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
18566128 GOA
involved in negative regulation of cellular response to growth factor stimulus IDA
IDA: Inferred from direct assay
16439689 GOA
involved in negative regulation of chemokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
18829537 GOA
involved in negative regulation of endothelial cell migration IDA
IDA: Inferred from direct assay
18345009 GOA
involved in negative regulation of lamellipodium assembly IDA
IDA: Inferred from direct assay
16439689 GOA
involved in negative regulation of leukocyte chemotaxis IDA
IDA: Inferred from direct assay
11309622 GOA
involved in negative regulation of mononuclear cell migration IDA
IDA: Inferred from direct assay
16439689 GOA
involved in negative regulation of neutrophil chemotaxis IDA
IDA: Inferred from direct assay
19759280 GOA
involved in negative regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
18345009 GOA
involved in negative regulation of retinal ganglion cell axon guidance IDA
IDA: Inferred from direct assay
17062560 GOA
involved in negative regulation of small GTPase mediated signal transduction IDA
IDA: Inferred from direct assay
16439689 GOA
involved in negative regulation of smooth muscle cell chemotaxis IDA
IDA: Inferred from direct assay
16439689 GOA
involved in negative regulation of smooth muscle cell migration IDA
IDA: Inferred from direct assay
16439689 GOA
involved in negative regulation of vascular permeability IDA
IDA: Inferred from direct assay
18345009 GOA
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
18566128 GOA
involved in response to cortisol IEP
IEP: Inferred from expression pattern
18566128 GOA
involved in retinal ganglion cell axon guidance IDA
IDA: Inferred from direct assay
10864954 GOA
involved in ureteric bud development IMP
IMP: Inferred from mutant phenotype
15130495 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
10102268 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
18566128 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
10102268 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLIT2 Protein Structure

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (27 - 54)

LRR_8

LRR_8: Leucine rich repeat (56 - 115)

LRR_8

LRR_8: Leucine rich repeat (153 - 211)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (234 - 258)

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (272 - 299)

LRR_8

LRR_8: Leucine rich repeat (302 - 360)

LRR_8

LRR_8: Leucine rich repeat (373 - 431)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (455 - 479)

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (505 - 532)

LRR_8

LRR_8: Leucine rich repeat (537 - 594)

LRR_8

LRR_8: Leucine rich repeat (607 - 664)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (688 - 713)

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (727 - 753)

LRR_1

LRR_1: Leucine Rich Repeat (778 - 800)

LRR_8

LRR_8: Leucine rich repeat (802 - 861)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (884 - 908)

EGF

EGF: EGF-like domain (922 - 952)

EGF

EGF: EGF-like domain (961 - 994)

EGF

EGF: EGF-like domain (1002 - 1031)

EGF

EGF: EGF-like domain (1040 - 1072)

EGF

EGF: EGF-like domain (1080 - 1109)

EGF

EGF: EGF-like domain (1125 - 1154)

Laminin_G_1

Laminin_G_1: Laminin G domain (1188 - 1318)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1529 a.a.
Protein Preferred Names Protein Names

slit homolog 2 protein

SLIT2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLIT2 O94813 SLIT2 Homo sapiens O94813
DLS
19498462
Intra
SLIT2 O94813 SLIT2 Homo sapiens O94813
X-Ray Diffraction
19498462
Intra
SLIT2 O94813 ROBO1 Homo sapiens Q9Y6N7
SPR
17848514
Intra
SLIT2 O94813 a0a2u2h391_yerpe Yersinia pestis A0A2U2H391
Y2H Pooling
20711500
Intra
SLIT2 O94813 HOXA1 Homo sapiens P49639
Y2H Pooling
21653829
Intra
SLIT2 O94813 ROBO1 Homo sapiens Q9Y6N7
X-Ray Diffraction
17848514
Intra
SLIT2 O94813 Q9WMX2-PRO_0000037548 Hepatitis C virus Q9WMX2-PRO_0000037548
Y2H
18985028
Intra
SLIT2 O94813 Q9WMX2-PRO_0000037546 Hepatitis C virus Q9WMX2-PRO_0000037546
Y2H
18985028
Intra
SLIT2 O94813 bilf1_ebvb9 Epstein-Barr virus P03208
Y2H
17446270
Cross: Cross-species interaction Intra: Intraspecies interaction

SLIT2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810777 Slit2 Antibody (YA10020) WB, IHC-P, IP Human, Mouse, Rat
HY-P87093 Slit2 Antibody (YA6786) WB, ICC/IF, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Cakut

  • Renal Or Urinary Tract Malformation

  • Congenital Anomalies Of Kidney And Urinary Tract

  • Congenital Anomaly Of Kidney And Urinary Tract

  • Congenital Anomalies Of The Kidney And Urinary Tract

  • Kidney And Urinary Tract, Anomalies, Congenital

  • Renal Hypodysplasia, Nonsyndromic, 1
Corneal Neovascularization

  • Corneal Neovascularisation

  • Corneal Vascularisation

  • Extensive Superficial Corneal Vascularisation
Barre-Lieou Syndrome

  • Cervicocranial Syndrome

  • Posterior Cervical Sympathetic Syndrome
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Vesicoureteral Reflux

  • Vesico-Ureteral Reflux
Renal Hypodysplasia/Aplasia 1

  • Renal Agenesis

  • Renal Adysplasia

  • Renal Aplasia

  • RHDA1

  • Hereditary Renal Aplasia

  • Hra

  • Hereditary Urogenital Adysplasia

  • Hypodysplasia/Aplasia, Renal, Type 1

  • Congenital Absence Of Kidneys Syndrome

  • Congenital Absence Of Kidney

  • Aplastic Kidney
Hirschsprung Disease 1

  • Hirschsprung Disease

  • Aganglionic Megacolon

  • Hscr

  • Hirschsprung'S Disease

  • Congenital Megacolon

  • Congenital Intestinal Aganglionosis

  • Colonic Aganglionosis

  • Hirschsprung Disease, Susceptibility To, 1

  • Hirschsprung Disease, Protection Against

  • HSCR1

  • Mgc

  • Pelvirectal Achalasia

  • Total Intestinal Aganglionosis

  • Megacolon, Aganglionic

  • Macrocolon

  • Hscr 1

  • Hirschsprung Disease Type 1

  • Hirschsprung Disease, Type 1

  • Congenital Dilatation Of Colon

  • Aganglionosis

  • Congenital Aganglionic Megacolon

  • Aganglionosis Of Colon

  • Bowel Aganglionosis

  • Colon Aganglionosis

  • Hirschsprung Megacolon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175200 DEL-S1 Ligand 98.50% Unkown
HY-146411 microRNA-21-IN-1 98.03% Unkown
HY-RS13371 SLIT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13372 SLIT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19035 Slit2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25524 Slit2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SLIT2 VGNC VGNC:77644
Mus musculus SLIT2 MGD MGI:1315205
Bos taurus SLIT2 VGNC VGNC:34960
Rattus norvegicus SLIT2 RGD RGD:69310
Canis familiaris SLIT2 VGNC VGNC:46504
Others SLIT2 NCBI