TGS1 - trimethylguanosine synthase 1 Gene

Also Known as PIMT; PIPMT; NCOA6IP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 96764

About TGS1

Cytogenetic location: 8q12.1 Genomic coordinates (GRCh38): 8:55,773,446-55,826,445 (from NCBI)

This gene has 3 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in lymph node (RPKM 6.7), appendix (RPKM 5.1) and 25 other tissues.

Summary

Enables RNA trimethylguanosine synthase activity. Involved in 7-methylguanosine cap hypermethylation. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TGS1 Products (3)

mRNA Protein Name
NM_001317902.2 NP_001304831.1 trimethylguanosine synthase isoform 2
NM_001363184.2 NP_001350113.1 trimethylguanosine synthase isoform 3
NM_024831.8 NP_079107.6 trimethylguanosine synthase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA cap trimethylguanosine synthase activity IDA
IDA: Inferred from direct assay
16687569 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21522132 GOA
Biological Process GO Annotation Evidence References Source
involved in 7-methylguanosine cap hypermethylation IDA
IDA: Inferred from direct assay
16687569 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12943661 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12943661 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TGS1 Protein Structure

Methyltransf_15

Methyltransf_15: RNA cap guanine-N2 methyltransferase (692 - 844)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 853 a.a.
Protein Preferred Names Protein Names

trimethylguanosine synthase

  • CLL-associated antigen KW-2

TGS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TGS1 Q96RS0 NOP58 Homo sapiens Q9Y2X3
Anti Tag CoIP
21522132
Intra
TGS1 Q96RS0 NOP58 Homo sapiens Q9Y2X3
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TGS1 Proteins

Cat. No. Product Name Accession Purity
HY-P71608 TGS1 Protein, Human (His-SUMO) Q96RS0 (M713-T853) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07679 LIN9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14466 TGS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19389 Tgs1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25881 Tgs1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TGS1 VGNC VGNC:35815
Felis catus TGS1 VGNC VGNC:66146
Macaca mulatta TGS1 VGNC VGNC:78404
Canis familiaris TGS1 VGNC VGNC:47321
Rattus norvegicus TGS1 RGD RGD:1309953
Mus musculus TGS1 MGD MGI:2151797
Others TGS1 NCBI