country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

NOP58 - NOP58 ribonucleoprotein Gene

Also Known as NOP5; HSPC120; NOP5/NOP58

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51602

About NOP58

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:202,265,763-202,303,661 (from NCBI)

This gene has 10 transcripts (splice variants), 215 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 29.6), lymph node (RPKM 29.1) and 25 other tissues.

Summary

The protein encoded by this gene is a core component of box C/D small nucleolar ribonucleoproteins. Some box C/D small nucleolar RNAs (snoRNAs), such as U3, U8, and U14, are dependent upon the encoded protein for their synthesis. This protein is SUMOylated, which is necessary for high affinity binding to snoRNAs. [provided by RefSeq, Nov 2015]

NOP58 Products (1)

mRNA	Protein	Name
NM_015934.5	NP_057018.1	nucleolar protein 58

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	17636026	GOA
enables TFIID-class transcription factor complex binding	IPI IPI: Inferred from physical interaction	17636026	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17636026	GOA
enables snoRNA binding	IDA IDA: Inferred from direct assay	17636026	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA
involved in snoRNA localization	IMP IMP: Inferred from mutant phenotype	17636026	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Cajal body	IDA IDA: Inferred from direct assay	16687569	GOA
part of box C/D methylation guide snoRNP complex	IDA IDA: Inferred from direct assay	33367824	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	16687569	GOA
part of pre-snoRNP complex	IDA IDA: Inferred from direct assay	17636026	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA
part of sno(s)RNA-containing ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17636026	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOP58 Protein Structure

NOP5NT

Nop

0
100
200
300
400
500
529 a.a.

Protein Preferred Names	Protein Names
nucleolar protein 58	NOP58 ribonucleoprotein homolog

NOP58 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NOP58	Q9Y2X3	NUFIP1	Homo sapiens	Q9UHK0	Anti Bait CoIP	17636026
Intra	NOP58	Q9Y2X3	NUFIP1	Homo sapiens	Q9UHK0	Anti Tag CoIP	35271311
Intra	NOP58	Q9Y2X3	NOPCHAP1	Homo sapiens	Q8N5I9	Anti Tag CoIP	35271311
Intra	NOP58	Q9Y2X3	NOPCHAP1	Homo sapiens	Q8N5I9	Anti Tag CoIP	33961781
Intra	NOP58	Q9Y2X3	SNU13	Homo sapiens	P55769	Crosslink	30021884
Intra	NOP58	Q9Y2X3	SNU13	Homo sapiens	P55769	Anti Tag CoIP	35271311
Intra	NOP58	Q9Y2X3	TGS1	Homo sapiens	Q96RS0	Pull Down	21522132

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09431	NOP58 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NOP58	RGD	RGD:620484
Canis familiaris	NOP58	VGNC	VGNC:43892
Bos taurus	NOP58	VGNC	VGNC:32170
Felis catus	NOP58	VGNC	VGNC:63859
Macaca mulatta	NOP58	VGNC	VGNC:75284
Mus musculus	NOP58	MGD	MGI:1933184
Others	NOP58	NCBI