21-Hydroxyisoohchininolide 

21-Hydroxyisoohchininolide is a salannin-type limonoid. 21-Hydroxyisoohchininolide inhibits lipopolysaccharide (LPS, HY-D1056)-induced nitric oxide production in mouse macrophages. 21-Hydroxyisoohchininolide exhibits cytotoxic activity against leukemia cells and breast cancer cells. 21-Hydroxyisoohchininolide suppresses phorbol 12-myristate 13-acetate (PMA) (HY-18739)-induced activation of Epstein-Barr virus early antigen in lymphocytes. 21-Hydroxyisoohchininolide can be used for the research of leukemia, breast cancer and inflammatory diseases^[1].

21-Hydroxyisoohchininolide (1×10^-6-1×10^-4 M; 48 h) exhibits cytotoxicity against HL60 human leukemia cells (IC₅₀ = 22.7 ± 1.6 μM) and SK-BR-3 human breast cancer cells (IC₅₀ = 91.5 ± 2.2 μM), but shows no cytotoxicity against A549 human lung cancer cells and AZ521 human stomach cancer cells after 48 h of treatment^[1].
21-Hydroxyisoohchininolide (1×10^-6-1×10^-4 M; 2 h pre-incubation, 16 h LPS co-incubation) inhibits LPS-induced nitric oxide production in RAW 264.7 murine macrophage cells with an IC₅₀ of 87.3 ± 4.5 μM, with no cytotoxicity to the cells after 16 h of LPS co-incubation^[1].
21-Hydroxyisoohchininolide (10-1000 molar ratio relative to 32 pmol TPA) inhibits TPA-induced EBV-EA activation in Raji cells with an IC₅₀ of 493 molar ratio relative to 32 pmol TPA, with 60% cell viability at the highest tested molar ratio of 1000:1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

634.71

C₃₆H₄₂O₁₀

1429747-14-7

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pan X, et al. Cytotoxic and nitric oxide production-inhibitory activities of limonoids and other compounds from the leaves and bark of Melia azedarach. Chem Biodivers. 2014;11(8):1121-1139.  [Content Brief]