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Art. -Nr.: HY-N18117

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21-Hydroxyisoohchininolide

21-Hydroxyisoohchininolide is a salannin-type limonoid. 21-Hydroxyisoohchininolide inhibits lipopolysaccharide (LPS, HY-D1056)-induced nitric oxide production in mouse macrophages. 21-Hydroxyisoohchininolide exhibits cytotoxic activity against leukemia cells and breast cancer cells. 21-Hydroxyisoohchininolide suppresses phorbol 12-myristate 13-acetate (PMA) (HY-18739)-induced activation of Epstein-Barr virus early antigen in lymphocytes. 21-Hydroxyisoohchininolide can be used for the research of leukemia, breast cancer and inflammatory diseases.

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CAS. Nr.: 1429747-14-7
Formel: C₃₆H₄₂O₁₀
Molecular Weight:634.71

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

21-Hydroxyisoohchininolide Chemical Structure

CAS. Nr.: 1429747-14-7

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

21-Hydroxyisoohchininolide (1×10^-6-1×10^-4 M; 48 h) exhibits cytotoxicity against HL60 human leukemia cells (IC₅₀ = 22.7 ± 1.6 μM) and SK-BR-3 human breast cancer cells (IC₅₀ = 91.5 ± 2.2 μM), but shows no cytotoxicity against A549 human lung cancer cells and AZ521 human stomach cancer cells after 48 h of treatment^[1].
21-Hydroxyisoohchininolide (1×10^-6-1×10^-4 M; 2 h pre-incubation, 16 h LPS co-incubation) inhibits LPS-induced nitric oxide production in RAW 264.7 murine macrophage cells with an IC₅₀ of 87.3 ± 4.5 μM, with no cytotoxicity to the cells after 16 h of LPS co-incubation^[1].
21-Hydroxyisoohchininolide (10-1000 molar ratio relative to 32 pmol TPA) inhibits TPA-induced EBV-EA activation in Raji cells with an IC₅₀ of 493 molar ratio relative to 32 pmol TPA, with 60% cell viability at the highest tested molar ratio of 1000:1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HL60 human leukemia cells, AZ521 human stomach cancer cells, A549 human lung cancer cells, SK-BR-3 human breast cancer cells
Concentration:

1, 10 and 100 μM
Incubation Time:

48 h
Result:

Exhibited cytotoxicity against HL60 cells with an IC₅₀ of 22.7 μM.
Exhibited cytotoxicity against SK-BR-3 cells with an IC₅₀ of 91.5 μM.
Showed no cytotoxicity (IC₅₀ > 100 μM) against A549 and AZ521 cells.

Chemical Information

CAS. Nr. 1429747-14-7
Molecular Weight 634.71
Formel C₃₆H₄₂O₁₀
SMILES

C[C@]12[C@@]3([H])[C@](OC[C@@]3([C@@H](C[C@@H]2OC(/C=C/C4=CC=CC=C4)=O)O)C)([H])[C@]5([H])[C@]([C@@H]1CC(OC)=O)(C6=C(C)[C@H](C7=CC(OC7O)=O)C[C@@]6([H])O5)C
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Pan X, et al. Cytotoxic and nitric oxide production-inhibitory activities of limonoids and other compounds from the leaves and bark of Melia azedarach. Chem Biodivers. 2014;11(8):1121-1139. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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