21-Hydroxyisoohchininolide
21-Hydroxyisoohchininolide is a salannin-type limonoid. 21-Hydroxyisoohchininolide inhibits lipopolysaccharide (LPS, HY-D1056)-induced nitric oxide production in mouse macrophages. 21-Hydroxyisoohchininolide exhibits cytotoxic activity against leukemia cells and breast cancer cells. 21-Hydroxyisoohchininolide suppresses phorbol 12-myristate 13-acetate (PMA) (HY-18739)-induced activation of Epstein-Barr virus early antigen in lymphocytes. 21-Hydroxyisoohchininolide can be used for the research of leukemia, breast cancer and inflammatory diseases.
For research use only. We do not sell to patients.
- CAS No.: 1429747-14-7
- Formula: C36H42O10
- Molecular Weight:634.71
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
21-Hydroxyisoohchininolide (1×10-6-1×10-4 M; 48 h) exhibits cytotoxicity against HL60 human leukemia cells (IC50 = 22.7 ± 1.6 μM) and SK-BR-3 human breast cancer cells (IC50 = 91.5 ± 2.2 μM), but shows no cytotoxicity against A549 human lung cancer cells and AZ521 human stomach cancer cells after 48 h of treatment[1].
21-Hydroxyisoohchininolide (1×10-6-1×10-4 M; 2 h pre-incubation, 16 h LPS co-incubation) inhibits LPS-induced nitric oxide production in RAW 264.7 murine macrophage cells with an IC50 of 87.3 ± 4.5 μM, with no cytotoxicity to the cells after 16 h of LPS co-incubation[1].
21-Hydroxyisoohchininolide (10-1000 molar ratio relative to 32 pmol TPA) inhibits TPA-induced EBV-EA activation in Raji cells with an IC50 of 493 molar ratio relative to 32 pmol TPA, with 60% cell viability at the highest tested molar ratio of 1000:1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HL60 human leukemia cells, AZ521 human stomach cancer cells, A549 human lung cancer cells, SK-BR-3 human breast cancer cells
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Concentration:1, 10 and 100 μM
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Incubation Time:48 h
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Result:Exhibited cytotoxicity against HL60 cells with an IC50 of 22.7 μM.
Exhibited cytotoxicity against SK-BR-3 cells with an IC50 of 91.5 μM.
Showed no cytotoxicity (IC50 > 100 μM) against A549 and AZ521 cells.
Chemical Information
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CAS No. 1429747-14-7
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Molecular Weight 634.71
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Formula C36H42O10
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SMILES
C[C@]12[C@@]3([H])[C@](OC[C@@]3([C@@H](C[C@@H]2OC(/C=C/C4=CC=CC=C4)=O)O)C)([H])[C@]5([H])[C@]([C@@H]1CC(OC)=O)(C6=C(C)[C@H](C7=CC(OC7O)=O)C[C@@]6([H])O5)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
21-Hydroxyisoohchininolide Related Classifications
HY-N18117 Related Classifications
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