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Cat. No.: HY-N12384

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(25S)-Antcin B

Antcin-B is a potent inhibitor of 3CLPro with high affinity. Antcin-B can be used in study SARS-CoV-2.

For research use only. We do not sell to patients.

CAS No.: 1312711-71-9
Formula: C₂₉H₄₀O₅
Molecular Weight:468.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

(25S)-Antcin B Chemical Structure

CAS No.: 1312711-71-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Antcin-B is a potent inhibitor of 3CLPro with high affinity. Antcin-B can be used in study SARS-CoV-2^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	57.4 μM Compound: 15	Cytotoxicity against human A549 cells after 48 hrs by SRB assay Cytotoxicity against human A549 cells after 48 hrs by SRB assay	[PMID: 24387703]
HL-60	IC₅₀	>100 μM Compound: 3	Cytotoxicity against human HL-60 cells Cytotoxicity against human HL-60 cells	[PMID: 33915258]
MCF7	IC₅₀	>100 μM Compound: 3	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 33915258]
MDA-MB-231	IC₅₀	44 μM Compound: 15	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay	[PMID: 24387703]
Neutrophil	IC₅₀	9.82 μM Compound: 11	Inhibition of fMLP-induced superoxide production in human neutrophils Inhibition of fMLP-induced superoxide production in human neutrophils	[PMID: 17559265]
SW480	IC₅₀	>100 μM Compound: 3	Cytotoxicity against human SW480 cells Cytotoxicity against human SW480 cells	[PMID: 33915258]
U-251	IC₅₀	>100 μM Compound: 3	Cytotoxicity against human U-251 cells Cytotoxicity against human U-251 cells	[PMID: 33915258]

Chemical Information

CAS No. 1312711-71-9
Molecular Weight 468.62
Formula C₂₉H₄₀O₅
SMILES

C[C@@]12C3=C(C(C[C@@]1([H])[C@@H](C(CC2)=O)C)=O)[C@@]4([H])[C@](CC3=O)([C@@](CC4)([H])[C@H](C)CCC([C@H](C)C(O)=O)=C)C
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
- Microorganisms
Taiwanofungus camphoratus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dakpa G, et al. Antcin-B, a phytosterol-like compound from Taiwanofungus camphoratus inhibits SARS-CoV-2 3-chymotrypsin-like protease (3CLPro) activity in silico and in vitro. Sci Rep. 2023 Oct 10;13(1):17106. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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