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Cat. No.: HY-N12384

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(25S)-Antcin B

Antcin-B is a potent inhibitor of 3CLPro with high affinity. Antcin-B can be used in study SARS-CoV-2.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1312711-71-9
Formule: C₂₉H₄₀O₅
Masse moléculaire:468.62

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

(25S)-Antcin B Chemical Structure

CAS No.: 1312711-71-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Antcin-B is a potent inhibitor of 3CLPro with high affinity. Antcin-B can be used in study SARS-CoV-2^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	57.4 μM Compound: 15	Cytotoxicity against human A549 cells after 48 hrs by SRB assay Cytotoxicity against human A549 cells after 48 hrs by SRB assay	[PMID: 24387703]
HL-60	IC₅₀	>100 μM Compound: 3	Cytotoxicity against human HL-60 cells Cytotoxicity against human HL-60 cells	[PMID: 33915258]
MCF7	IC₅₀	>100 μM Compound: 3	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 33915258]
MDA-MB-231	IC₅₀	44 μM Compound: 15	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay	[PMID: 24387703]
Neutrophil	IC₅₀	9.82 μM Compound: 11	Inhibition of fMLP-induced superoxide production in human neutrophils Inhibition of fMLP-induced superoxide production in human neutrophils	[PMID: 17559265]
SW480	IC₅₀	>100 μM Compound: 3	Cytotoxicity against human SW480 cells Cytotoxicity against human SW480 cells	[PMID: 33915258]
U-251	IC₅₀	>100 μM Compound: 3	Cytotoxicity against human U-251 cells Cytotoxicity against human U-251 cells	[PMID: 33915258]

Chemical Information

CAS No. 1312711-71-9
Masse moléculaire 468.62
Formule C₂₉H₄₀O₅
SMILES

C[C@@]12C3=C(C(C[C@@]1([H])[C@@H](C(CC2)=O)C)=O)[C@@]4([H])[C@](CC3=O)([C@@](CC4)([H])[C@H](C)CCC([C@H](C)C(O)=O)=C)C
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
- Microorganisms
Taiwanofungus camphoratus
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Dakpa G, et al. Antcin-B, a phytosterol-like compound from Taiwanofungus camphoratus inhibits SARS-CoV-2 3-chymotrypsin-like protease (3CLPro) activity in silico and in vitro. Sci Rep. 2023 Oct 10;13(1):17106. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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