1. GPCR/G Protein
  2. Oxytocin Receptor
  3. Carbetocin

Carbetocin 

Cat. No.: HY-17573 Purity: ≥98.0%
Handling Instructions

Carbetocin, an oxytocin (OT) analogue, is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin has high affinity to chimeric N-terminus (E1) of the oxytocin receptor (Ki=1.17 μM). Carbetocin has the potential for postpartum hemorrhage research. Carbetocin can crosse the blood-brain barrier and produces antidepressant-like activity via activation of oxytocin receptors in the CNS.

For research use only. We do not sell to patients.

Carbetocin Chemical Structure

Carbetocin Chemical Structure

CAS No. : 37025-55-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 98 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 98 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 65 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
50 mg USD 350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 650 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Carbetocin, an oxytocin (OT) analogue, is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin has high affinity to chimeric N-terminus (E1) of the oxytocin receptor (Ki=1.17 μM). Carbetocin has the potential for postpartum hemorrhage research. Carbetocin can crosse the blood-brain barrier and produces antidepressant-like activity via activation of oxytocin receptors in the CNS[1][2][3].

In Vitro

Carbetocin is an agonist with about 10-fold lower affinity for the oxytocin receptor but with significantly higher stability and a longer duration of action. Carbetocin has higher affinity to the chimeric E1 receptor and especially to each of the combinations of E1 with the other extracellular domains, i.e. chimeric receptors E13 (Ki=13 nM), E123 (Ki=56 nM), and E1234 (Ki=37 nM)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Carbetocin (2-20 mg/kg; i.p.) has a significant effect of treatment on the percent time spent climbing, swimming and immobile[1].
Carbetocin (1, 10,100 μg/rat, i.c.v.) reveals a dose-dependent increase in the percent time spent swimming and a corresponding reduction in immobility following acute administration of 100 μg/rat[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats weighing between 300 and 500 g[1]
Dosage: 2, 6.4, 20 mg/kg
Administration: IP; single dose
Result: Increased climbing with 6.4 mg/kg and resulted in a significantly greater proportion of time spent swimming with 20 mg/kg.
Clinical Trial
Molecular Weight

988.16

Formula

C₄₅H₆₉N₁₁O₁₂S

CAS No.
SMILES

O=C([[email protected]](CSCCCC(N[[email protected]](C1=O)CC2=CC=C(OC)C=C2)=O)NC([[email protected]@H](NC([[email protected]](NC([[email protected]](N1)([H])[[email protected]@H](C)CC)=O)([H])CCC(N)=O)=O)CC(N)=O)=O)N(CCC3)[[email protected]@H]3C(N[[email protected]@H](CC(C)C)C(NCC(N)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (31.37 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0120 mL 5.0599 mL 10.1198 mL
5 mM 0.2024 mL 1.0120 mL 2.0240 mL
10 mM 0.1012 mL 0.5060 mL 1.0120 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.53 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.53 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.53 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: ≥98.0%

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Keywords:

CarbetocinOxytocin ReceptorOXTRN-terminusE1postpartumhemorrhageantidepressant-likeblood-brainbarrierbbbInhibitorinhibitorinhibit

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Carbetocin
Cat. No.:
HY-17573
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