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Carnostatine (Synonyms: SAN9812)

Cat. No.: HY-112431
Handling Instructions

Carnostatine (SAN9812) is a potent and selective carnosinase 1 (CN1) inhibitor with a Ki of 11 nM for human recombinant CN1. Carnostatine (SAN9812) can be used for the treatment of diabetic nephropathy (DN).

For research use only. We do not sell to patients.

Carnostatine Chemical Structure

Carnostatine Chemical Structure

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Description

Carnostatine (SAN9812) is a potent and selective carnosinase 1 (CN1) inhibitor with a Ki of 11 nM for human recombinant CN1. Carnostatine (SAN9812) can be used for the treatment of diabetic nephropathy (DN)[1].

IC50 & Target

Ki: 11 nM (human CN1)[1]

In Vitro

Carnostatine (SAN9812) also inhibits CN1 activity in human serum and serum of transgenic mice-overexpressing human CN1. Carnostatine, with an IC50 value of 18 nM on human recombinant CN1 at a carnosine concentration of 200 µM, i.e., close to the Km of 190 µM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Subcutaneous administration of 30 mg/kg Carnostatine (SAN9812) leads to a sustained reduction in circulating CN1 activity in human CN1 transgenic (TG) mice. Simultaneous administration of Carnosine and Carnostatine increases carnosine levels in plasma and kidney by up to 100-fold compared to treatment-naïve CN1-overexpressing mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human carnosinase (CNDP1) transgenic mice on a BTBR wt/ob background[1]
Dosage: 3 mg/kg i.v. or 30 mg/kg s.c. (Pharmacokinetic Analysis)
Administration: Single bolus administration
Result: Subcutaneous administration of 30 mg/kg led to a sustained reduction in circulating CN1 activity.
Molecular Weight

256.26

Formula

C₁₀H₁₆N₄O₄

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Carnostatine
Cat. No.:
HY-112431
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