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Carnostatine (Synonyms: SAN9812)

Cat. No.: HY-112431
Handling Instructions

Carnostatine (SAN9812) is a specific and highly selective carnosinase (CN1) inhibitor with a Ki of 11 nM.

For research use only. We do not sell to patients.

Carnostatine Chemical Structure

Carnostatine Chemical Structure

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Description

Carnostatine (SAN9812) is a specific and highly selective carnosinase (CN1) inhibitor with a Ki of 11 nM.

IC50 & Target

Ki: 11 nM (Carnosinase, CN1)[1]

In Vitro

Carnostatine (SAN9812) is a potent CN1 activity inhibitor with an IC50 value of 18 nM on human recombinant CN1 at a carnosine concentration of 200 µM, i.e., close to the Km of 190 µM. Carnostatine is a competitive inhibitor, showing a right-shift in its IC50 value with increasing carnosine concentration. The Ki value of Carnostatine is determined as 11 nM[1].

In Vivo

CN1 activity is measured after a single subcutaneous bolus of 30 mg/kg Carnostatine (SAN9812). Animals are stratified according to their baseline serum carnosinase activity into a high-activity- (> 250 µmol/mL/h) and a low-activity (< 45 µmol/mL/h) group. Mean baseline activities in the two groups are 259±13 and 7.4±4.9 µmol/mL/h, respectively. Administration of Carnostatine leads to a rapid reduction in serum carnosinase activity by more than 90% in both groups which is sustained for > 8 h. At the last sampling time point 16 h after Carnostatine administration, serum carnosinase activity is still reduced by 40% in the low-activity group and by 75% in the high-activity group[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

256.26

Formula

C₁₀H₁₆N₄O₄

SMILES

OC([[email protected]@H](NC([[email protected]@H](O)CCN)=O)CC1=CNC=N1)=O

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Carnostatine
Cat. No.:
HY-112431
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Carnostatine

Cat. No.: HY-112431