2. Peptides
  3. Carnostatine

Carnostatine (SAN9812) is a potent and selective carnosinase 1 (CN1) inhibitor with a Ki of 11 nM for human recombinant CN1. Carnostatine (SAN9812) can be used for the treatment of diabetic nephropathy (DN).

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Carnostatine hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

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Carnostatine Chemical Structure

Carnostatine Chemical Structure

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Other Forms of Carnostatine:

Carnostatine Related Antibodies

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Description

Carnostatine (SAN9812) is a potent and selective carnosinase 1 (CN1) inhibitor with a Ki of 11 nM for human recombinant CN1. Carnostatine (SAN9812) can be used for the treatment of diabetic nephropathy (DN)[1].

IC50 & Target

Ki: 11 nM (human CN1)[1]
In Vitro

Carnostatine (SAN9812) also inhibits CN1 activity in human serum and serum of transgenic mice-overexpressing human CN1. Carnostatine, with an IC50 value of 18 nM on human recombinant CN1 at a carnosine concentration of 200 µM, i.e., close to the Km of 190 µM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Carnostatine Related Antibodies
In Vivo

Subcutaneous administration of 30 mg/kg Carnostatine (SAN9812) leads to a sustained reduction in circulating CN1 activity in human CN1 transgenic (TG) mice. Simultaneous administration of Carnosine and Carnostatine increases carnosine levels in plasma and kidney by up to 100-fold compared to treatment-naïve CN1-overexpressing mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human carnosinase (CNDP1) transgenic mice on a BTBR wt/ob background[1]
Dosage: 3 mg/kg i.v. or 30 mg/kg s.c. (Pharmacokinetic Analysis)
Administration: Single bolus administration
Result: Subcutaneous administration of 30 mg/kg led to a sustained reduction in circulating CN1 activity.
Molecular Weight

256.26

Formula

C10H16N4O4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CarnostatineSAN9812SAN 9812SAN-9812OthersCarnosinaseCN1Diabeticnephropathiesdiabetes ,T2DrenaldiseaseESRDInhibitorinhibitorinhibit

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Carnostatine
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