Carnostatine
Carnostatine (SAN9812) is a potent and selective carnosinase 1 (CN1) inhibitor with a Ki of 11 nM for human recombinant CN1. Carnostatine (SAN9812) can be used for the treatment of diabetic nephropathy (DN).
For research use only. We do not sell to patients.
- Formula: C10H16N4O4
- Molecular Weight:256.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Ki: 11 nM (human CN1)[1]
Carnostatine (SAN9812) also inhibits CN1 activity in human serum and serum of transgenic mice-overexpressing human CN1. Carnostatine, with an IC50 value of 18 nM on human recombinant CN1 at a carnosine concentration of 200 μM, i.e., close to the Km of 190 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Human carnosinase (CNDP1) transgenic mice on a BTBR wt/ob background[1]
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Dosage:3 mg/kg i.v. or 30 mg/kg s.c. (Pharmacokinetic Analysis)
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Administration:Single bolus administration
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Result:Subcutaneous administration of 30 mg/kg led to a sustained reduction in circulating CN1 activity.
Chemical Information
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Molecular Weight 256.26
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Formula C10H16N4O4
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Synonyms
SAN9812
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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