Carnostatine hydrochloride
Based on 1 Customer Validation
Carnostatine hydrochloride (SAN9812 hydrochloride) is a potent and selective carnosinase 1 (CN1) inhibitor with a Ki of 11 nM for human recombinant CN1. Carnostatine hydrochloride can be used for the treatment of diabetic nephropathy (DN).
For research use only. We do not sell to patients.
- Purity: 99.89%
- Formula: C10H17ClN4O4
- Molecular Weight:292.72
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Ki: 11 nM (human CN1)[1]
Carnostatine (SAN9812) also inhibits CN1 activity in human serum and serum of transgenic mice-overexpressing human CN1. Carnostatine, with an IC50 value of 18 nM on human recombinant CN1 at a carnosine concentration of 200 μM, i.e., close to the Km of 190 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Human carnosinase (CNDP1) transgenic mice on a BTBR wt/ob background[1]
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Dosage:3 mg/kg i.v. or 30 mg/kg s.c. (Pharmacokinetic Analysis)
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Administration:Single bolus administration
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Result:Subcutaneous administration of 30 mg/kg led to a sustained reduction in circulating CN1 activity.
Chemical Information
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Appearance Solid
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Molecular Weight 292.72
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Formula C10H17ClN4O4
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Color White to off-white
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Synonyms
SAN9812 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 250 mg/mL (854.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 200 mg/mL (683.25 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (341.62 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.4162 mL | 17.0812 mL | 34.1623 mL | 85.4058 mL |
| 5 mM | 0.6832 mL | 3.4162 mL | 6.8325 mL | 17.0812 mL | |
| 10 mM | 0.3416 mL | 1.7081 mL | 3.4162 mL | 8.5406 mL | |
| 15 mM | 0.2277 mL | 1.1387 mL | 2.2775 mL | 5.6937 mL | |
| 20 mM | 0.1708 mL | 0.8541 mL | 1.7081 mL | 4.2703 mL | |
| 25 mM | 0.1366 mL | 0.6832 mL | 1.3665 mL | 3.4162 mL | |
| 30 mM | 0.1139 mL | 0.5694 mL | 1.1387 mL | 2.8469 mL | |
| 40 mM | 0.0854 mL | 0.4270 mL | 0.8541 mL | 2.1351 mL | |
| 50 mM | 0.0683 mL | 0.3416 mL | 0.6832 mL | 1.7081 mL | |
| 60 mM | 0.0569 mL | 0.2847 mL | 0.5694 mL | 1.4234 mL | |
| 80 mM | 0.0427 mL | 0.2135 mL | 0.4270 mL | 1.0676 mL | |
| 100 mM | 0.0342 mL | 0.1708 mL | 0.3416 mL | 0.8541 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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