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Carnostatine hydrochloride (Synonyms: SAN9812 hydrochloride)

Cat. No.: HY-112431A Purity: >95.0%
Handling Instructions

Carnostatine hydrochloride (SAN9812 hydrochloride) is a potent and selective carnosinase 1 (CN1) inhibitor with a Ki of 11 nM for human recombinant CN1. Carnostatine hydrochloride can be used for the treatment of diabetic nephropathy (DN).

For research use only. We do not sell to patients.

Carnostatine hydrochloride Chemical Structure

Carnostatine hydrochloride Chemical Structure

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10 mM * 1 mL in DMSO USD 161 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 400 In-stock
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25 mg USD 750 In-stock
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50 mg USD 1100 In-stock
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100 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Carnostatine hydrochloride (SAN9812 hydrochloride) is a potent and selective carnosinase 1 (CN1) inhibitor with a Ki of 11 nM for human recombinant CN1. Carnostatine hydrochloride can be used for the treatment of diabetic nephropathy (DN)[1].

IC50 & Target

Ki: 11 nM (human CN1)[1]

In Vitro

Carnostatine (SAN9812) also inhibits CN1 activity in human serum and serum of transgenic mice-overexpressing human CN1. Carnostatine, with an IC50 value of 18 nM on human recombinant CN1 at a carnosine concentration of 200 µM, i.e., close to the Km of 190 µM[1].

In Vivo

Subcutaneous administration of 30 mg/kg Carnostatine (SAN9812) leads to a sustained reduction in circulating CN1 activity in human CN1 transgenic (TG) mice. Simultaneous administration of Carnosine and Carnostatine increases carnosine levels in plasma and kidney by up to 100-fold compared to treatment-naïve CN1-overexpressing mice[1].

Animal Model: Human carnosinase (CNDP1) transgenic mice on a BTBR wt/ob background[1]
Dosage: 3 mg/kg i.v. or 30 mg/kg s.c. (Pharmacokinetic Analysis)
Administration: Single bolus administration
Result: Subcutaneous administration of 30 mg/kg led to a sustained reduction in circulating CN1 activity.
Molecular Weight

292.72

Formula

C₁₀H₁₇ClN₄O₄

SMILES

OC([[email protected]@H](NC([[email protected]@H](O)CCN)=O)CC1=CNC=N1)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

CarnostatineSAN9812SAN 9812SAN-9812OthersCarnosinaseCN1Diabeticnephropathiesdiabetes ,T2DrenaldiseaseESRDInhibitorinhibitorinhibit

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Product name:
Carnostatine hydrochloride
Cat. No.:
HY-112431A
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