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Iopromide 

Cat. No.: HY-B1362 Purity: 99.71%
Handling Instructions

Iopromide is a water-soluble, non-ionic, monomeric, low-osmolar, iodine-based contrast medium for intravascular administration.

For research use only. We do not sell to patients.

Iopromide Chemical Structure

Iopromide Chemical Structure

CAS No. : 73334-07-3

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
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10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
25 mg USD 120 In-stock
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50 mg USD 160 In-stock
Estimated Time of Arrival: December 31
100 mg USD 220 In-stock
Estimated Time of Arrival: December 31
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  • Biological Activity

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  • References

Description

Iopromide is a water-soluble, non-ionic, monomeric, low-osmolar, iodine-based contrast medium for intravascular administration.

In Vivo

Contrast medium-induced nephropathy can be induced by tail intravenous administration of iopromide[1]. In randomized controlled trials, the global image quality and diagnostic quality with iobitridol does not differ from those with other low-osmolar contrast media (iohexol, iopromide, iopamidol, iomeprol and ioxaglate) or the iso-osmolar contrast medium iodixanol in adults or children undergoing radiographic imaging. Large post-marketing surveillance studies have confirmed that iobitridol produces good or excellent opacification and is an effective contrast agent in the vast majority of patients. Iobitridol is generally well tolerated and had a tolerability profile similar to that of other low-osmolar and iso-osmolar contrast media. Thus, iobitridol is an effective intravascular agent for contrast enhancement in diagnostic imaging[2].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 150 mg/mL (189.61 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2640 mL 6.3202 mL 12.6405 mL
5 mM 0.2528 mL 1.2640 mL 2.5281 mL
10 mM 0.1264 mL 0.6320 mL 1.2640 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Mice: Male C57/BL6J mice are randomly divided into 7 groups: control, diabetes mellitus (D), CIN, diabetes mellitus+CIN (DC), diabetes mellitus+Breviscapine (DB), CIN+Breviscapine (CIN+B) and diabetes mellitus+CIN+Breviscapine (DCB). After the model of diabetes mellitus is established, mice are prohibited drinking water for one night, and then mice are injected at a dose of 10 mL/kg iopromide via tail vein administration over the course of 1 minute. Then the mice are treated intragastrically with or without Breviscapine (10 mg/kg/d) for 4 weeks. Other mice groups except for Breviscapine treatment groups (DB, DCB and CIN+B) are administered the same volume of phosphate buffered solution intragastrically for 4 weeks. Then mice are sacrificed by an intraperitoneal injection of chloral hydrate[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

791.11

Formula

C₁₈H₂₄I₃N₃O₈

CAS No.

73334-07-3

SMILES

O=C(C1=C(I)C(NC(COC)=O)=C(I)C(C(NCC(O)CO)=O)=C1I)N(CC(O)CO)C

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Iopromide
Cat. No.:
HY-B1362
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Iopromide

Cat. No.: HY-B1362