1. GPCR/G Protein
  2. Oxytocin Receptor

OT antagonist 1 

Cat. No.: HY-103650
Handling Instructions

OT antagonist 1 (Compound 4) is a potent, selective Oxytocin antagonist with a Ki of 50 nM.

For research use only. We do not sell to patients.

OT antagonist 1 Chemical Structure

OT antagonist 1 Chemical Structure

CAS No. : 479080-38-1

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

OT antagonist 1 (Compound 4) is a potent, selective Oxytocin antagonist with a Ki of 50 nM.

IC50 & Target

Ki: 50 nM (Oxytocin)[1]

In Vitro

Oxytocin (OT) is a nonapeptide hormone that acts on the OT receptor, a seven-transmembrane (7TM) (Gq-coupled) receptor. The OT receptor has no subtypes but is related to the vasopressin receptors V1A, V1B and V2. OT antagonists have therapeutic potential in a number of areas including pre-term labour: Benign Prostatic Hyperplasia and sexual dysfunction. As a result there is significant interest in the identification of potent, selective, orally bioavailable OT antagonists[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5612 mL 12.8061 mL 25.6121 mL
5 mM 0.5122 mL 2.5612 mL 5.1224 mL
10 mM 0.2561 mL 1.2806 mL 2.5612 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

390.44

Formula

C₂₂H₂₂N₄O₃

CAS No.

479080-38-1

SMILES

CC1=NOC([[email protected]@H](N(C(C2=CC=C(C3=CC=CC=C3C)C=C2)=O)C/4)CC4=N/OC)=N1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
OT antagonist 1
Cat. No.:
HY-103650
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OT antagonist 1

Cat. No.: HY-103650