Calmodulin
Calmodulin; CaM; Calcium-Modulated Protein
Calmodulin is the highly conserved, calcium-sensitive protein, that acts as the calcium ion sensor in cells, Ca2+-dependently binds to target proteins, and converts Ca2+ concentrations into cellular signals. Calmodulin has four different Ca2+ binding sites named EF-hand for the sensing of Ca2+ signaling with different amplitude, duration, and location. Calmodulin dysfunction could lead to myocardial contractile problems, neuronal damage, or tumor angiogenesis dysregulation, which may cause cardiovascular diseases, neurological diseases, or cancer[1][2][3].
References:
- [1]. Means AR, et al., Calmodulin--an intracellular calcium receptor. Nature. 1980 May 8;285(5760):73-7. doi: 10.1038/285073a0 [Content Brief]
- [2]. Kawasaki H, et al., Molecular Dynamics Study of the Changes in Conformation of Calmodulin with Calcium Binding and/or Target Recognition. Sci Rep. 2019 Jul 23;9(1):10688. [Content Brief]
- [3]. Crotti L, et al., Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry. Eur Heart J. 2023 Sep 14;44(35):3357-3370. [Content Brief]
Calmodulin Isoform Specific Products
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Calmodulin Related Products (62)
Related Products (62)
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Antibodies (4)
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Calmodulin Isoform Comparison
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Metofenazate diethanesulfonate
0 ImagesCat. No.: HY-100263BCAS No.: 1674-48-2Synonyms: Methophenazine diethanesulfonateMetofenazate diethanesulfonate is a selective calmodulin inhibitor.
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Arundic Acid (Standard)
0 ImagesCat. No.: HY-107661RCAS No.: 185517-21-9Synonyms: ONO-2506 (Standard); (R)-2-Propyloctanoic acid (Standard)Propiverine (hydrochloride) (Standard) is the analytical standard of Propiverine (hydrochloride). This product is intended for research and analytical applications. Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence.
