1. Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
    Apoptosis
  2. Reactive Oxygen Species
    Apoptosis
  3. AlbA-DCA

AlbA-DCA 

Cat. No.: HY-130117
Handling Instructions

AlbA-DCA is a conjugate formed by the attachment of Albiziabioside A (AlbA) to a dichloroacetate acid (DCA) subunit. AlbA-DCA can induce a marked increase in intracellular ROS and alleviate the accumulation of lactic acid in tumor microenvironment (TME), and also selectively kills cancer cells and induce apoptosis.

For research use only. We do not sell to patients.

AlbA-DCA Chemical Structure

AlbA-DCA Chemical Structure

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Description

AlbA-DCA is a conjugate formed by the attachment of Albiziabioside A (AlbA) to a dichloroacetate acid (DCA) subunit. AlbA-DCA can induce a marked increase in intracellular ROS and alleviate the accumulation of lactic acid in tumor microenvironment (TME), and also selectively kills cancer cells and induce apoptosis[1].

IC50 & Target

ROS[1]

In Vitro

AlbA-DCA exhibits the cytotoxicity against the MCF-7 cells, HCT116 cells, A375 cells, 4T1 cells, HBMEC cells and LO2 cells with IC50 values of 0.43 μM, 3.87 μM, 3.78 μM, 1.31 μM, 38.20 μM and 53.14 μM, respectively[1].
AlbA-DCA (2 μM; 24 hours; MCF-7 cells) treatment induces apoptotic cell death in MCF-7 cells[1].
AlbA-DCA (2 μM; MCF-7 cells) treatment could significantly up-regulate the expression of cytochrome c and down-regulate the expression of antiapoptotic protein Bcl-2. AlbA-DCA significantly enhances the expression of caspase-9[1].

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 2 μM
Incubation Time: 24 hours
Result: Induced apoptosis of MCF-7 cells.

Western Blot Analysis[1]

Cell Line: MCF-7 cells
Concentration: 2 μM
Incubation Time:
Result: Could significantly up-regulate the expression of cytochrome c and down-regulate the expression of antiapoptotic protein Bcl-2. Significantly enhanced the expression of caspase-9.
In Vivo

AlbA-DCA (2 mg/kg; subcutaneous injection; every 2 days; for 2 weeks; nude mice) treatment displays antitumor efficacy and almost completely suppresses tumor progression, and no mouse deaths and no significant changes in body weight are observed. AlbA-DCA has no obvious toxicity of liver and kidney and no major abnormality is observed in heart, liver, spleen, lung, and kidney[1].

Animal Model: Nude mice bearing MCF-7 tumors[1]
Dosage: 2 mg/kg
Administration: Subcutaneous injection; every 2 days; for 2 weeks
Result: Displayed the best antitumor efficacy and almost completely suppressed tumor progression.
Molecular Weight

860.90

Formula

C₄₃H₆₇Cl₂NO₁₂

SMILES
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AlbA-DCAReactive Oxygen SpeciesApoptosisInhibitorinhibitorinhibit

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AlbA-DCA
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HY-130117
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