Mesothelin Antibody (YA4237)
(Synonyms: MPF; SMRP)Mesothelin Antibody (YA4237) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Mesothelin.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, ELISA
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Reactivity :
Human, Rat
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:10000 |
Product Details
Mesothelin Antibody (YA4237) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Mesothelin.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Rat
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Observed Molecular WeightObserved band size: 45 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 69 kDa
Purified recombinant fragment of human MSLN (AA: 296-606) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Mesothelin is a cell surface glycoprotein that is normally expressed at low levels on mesothelial cells. Mesothelin is overexpressed in several types of cancers, including mesothelioma, ovarian cancer, and pancreatic cancer. Mesothelin can interact with other molecules such as megakaryocyte potentiating factor (MPF) and play roles in cell adhesion, migration and signal transduction. Mesothelin is an important target for cancer immunotherapy and diagnosis due to its differential expression in cancer cells[1][2][3].
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Subcellular Localization
Cell membrane; Lipid-anchor, GPI-anchor; Golgi apparatus; Secreted; Secreted
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Expression
Tissue_specificity:It is expressed in the lungs. It is expressed at low levels in the heart, placenta, and kidneys. It is expressed in mesothelial cells. It is highly expressed (protein level) in mesothelioma, ovarian cancer, and certain squamous cell carcinomas. -
Isoforms & Post-Translational Modification
Q13421 has 4 isomers: Q13421-1: 68986 Da (predicted); Q13421-3: 68070 Da (predicted); Q13421-2: 71492 Da (predicted); Q13421-4: 67940 Da (predicted).
Both MPF and the cleaved form of mesothelin are N-glycosylated;Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin -
Subunit
Interacts with MUC16
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SwissProt ID
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Synonyms
MPF; SMRP
Documentation
[1]. Hassan R, et al. Mesothelin Immunotherapy for Cancer: Ready for Prime Time? J Clin Oncol. 2016 Dec;34(34):4171-4179. [Content Brief]
[2]. Faust JR, et al. Mesothelin: An Immunotherapeutic Target beyond Solid Tumors. Cancers (Basel). 2022 Mar 18;14(6):1550. [Content Brief]
[3]. Kaeding AJ, et al. Mesothelin is a novel cell surface disease marker and potential therapeutic target in acute myeloid leukemia. Blood Adv. 2021 May 11;5(9):2350-2361. [Content Brief]
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