MSLN - mesothelin Gene

Also Known as MPF; SMRP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10232

About MSLN

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:760,734-768,865 (from NCBI)

This gene has 8 transcripts (splice variants), 115 orthologues and 3 paralogues. Biased expression in lung (RPKM 16.4), stomach (RPKM 4.7) and 7 other tissues.

Summary

This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and Mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

MSLN Products (3)

mRNA	Protein	Name
NM_001177355.3	NP_001170826.1	mesothelin isoform 1 preproprotein
NM_005823.6	NP_005814.2	mesothelin isoform 1 preproprotein
NM_013404.4	NP_037536.2	mesothelin isoform 2 preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14676194	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MSLN Protein Structure

Mesothelin

0
100
200
300
400
500
600
630 a.a.

Protein Preferred Names	Protein Names
mesothelin	CAK1 antigen

Recombinant MSLN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70148	Mesothelin Protein, Human (303a.a, HEK293, His)	AAH09272.1 (E296-S598)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70413	MPF Protein, Human (HEK293, His)	Q13421-2 (L37-R286)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72398	Mesothelin Protein, Human (Biotinylated, HEK293, His-Avi)	AAH09272.1 (E296-S598)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73818	MPF Protein, Human (HEK293, Fc)	Q13421-2 (L37-R286)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73819	Mesothelin Protein, Human (285a.a, HEK293, Fc)	Q13421-2 (E296-G580)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77546	Mesothelin Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q13421-2 (E296-G580)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77547	MPF Protein, Human (Biotinylated, HEK293, His)	Q13421-2 (L37-R286)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78369	FITC-Labeled Mesothelin Protein, Human (HEK293, Fc)	Q13421-2 (E296-G580)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78370	Mesothelin Protein, Human (HEK293, His-Avi)	Q13421-2 (E296-G580)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78371	FITC-Labeled Mesothelin Protein, Human (HEK293, His-Avi)	Q13421-2 (E296-G580)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78644	FITC-Labeled Mesothelin Protein, Human (HEK293, His)	AAH09272.1 (E296-G580)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700426	Mesothelin Protein, Human (HEK293, hFc)	AAH09272.1 (E296-S598)	≥ 95%, as determined by reducing SDS-PAGE.

MSLN Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81412	Mesothelin Antibody (YA1157)	IHC-P	Human
HY-P81412A	Mesothelin Antibody (YA1157)(PBS only)	IHC-P	Human
HY-P84539	Mesothelin Antibody (YA4236)	WB, FC, ELISA	Human, Monkey
HY-P84539A	Mesothelin Antibody (YA4236)(PBS only)	WB, FC, ELISA	Human, Monkey
HY-P84540	Mesothelin Antibody (YA4237)	WB, ELISA	Human, Rat
HY-P84540A	Mesothelin Antibody (YA4237)(PBS only)	WB, ELISA	Human, Rat
HY-P85960	Mesothelin Antibody (YA5652)	IHC-P, WB, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Benign Mesothelioma	Mesothelioma Benign Tumor Of Mesothelium Adenomatoid Tumor
Asbestosis	Idiopathic Interstitial Pneumonitis - From Asbestos Exposure Pulmonary Fibrosis - From Asbestos Exposure
Malignant Pleural Mesothelioma	Malignant Mesothelioma Of Pleura Pleural Malignant Mesothelioma
Peritoneal Mesothelioma	Malignant Mesothelioma Of Peritoneum Advanced Malignant Mesothelioma Of Peritoneum Advanced Malignant Peritoneal Mesothelioma Advanced Peritoneal Malignant Mesothelioma
Mesothelioma, Malignant	Malignant Mesothelioma Pleural Mesothelioma MESOM Mesothelioma, Somatic Advanced Malignant Mesothelioma Asbestos-Related Malignant Mesothelioma Diffuse Malignant Mesothelioma Malignant Tumor Of Mesothelium Malignant Mesothelioma, Susceptibility To Mesothelioma Diffuse Malignant Mesothelioma Malignant Pleural Mesothelioma
Refractory Hairy Cell Leukemia
Refractory Hematologic Cancer	Refractory Hematologic Malignancy
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Peritoneum Cancer	Peritoneal Neoplasm Cancer Of Peritoneum Malignant Tumor Of Peritoneum Peritoneal Neoplasms
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Thymic Carcinoma	Malignant Thymoma Thymoma, Malignant
Sarcomatoid Mesothelioma	Malignant Fibrous Mesothelioma Spindled Mesothelioma
Pleural Cancer	Pleural Neoplasms Neoplasm Of Pleura Pleural Tumor Malignant Tumor Of Pleura Pleural Cavity Cancer Primary Malignant Neoplasm Of Parietal Pleura Primary Malignant Neoplasm Of Pleura Primary Malignant Neoplasm Of Visceral Pleura
Pleural Disease	Pleural Diseases Disorder Of Pleura Non-Neoplastic Pleural Disease Pleural Disorders Non-Neoplastic Pleural Disorder
Malignant Biphasic Mesothelioma	Mesothelioma, Biphasic, Malignant Mixed Mesothelioma
Malignant Epithelial Mesothelioma	Epithelioid Mesothelioma, Malignant
Liver Fibroma	Fibroma Of The Liver Liver Solitary Fibrous Tumor
Pericardial Mesothelioma	Malignant Mesothelioma Of Pericardium Malignant Pericardial Mesothelioma
Fallopian Tube Carcinoma	Fallopian Tube Cancer Cancer Of The Fallopian Tube Carcinoma Of Fallopian Tube Neoplasm Of Fallopian Tube Fallopian Tube Neoplasms Fallopian Tube Ca Fallopian Tube Neoplasm Malignant Neoplasm Of Uterine Tube Malignant Tumor Of Fallopian Tube Malignant Tumour Of Fallopian Tube Tumor Of The Fallopian Tube Tumor, Fallopian Tube, Malignant Malignant Tumor Of Fallopian Tubes Cancer Of Fallopian Tubes Malignant Tubal Tumor Tubal Cancer Malignant Neoplasm Of Fallopian Tube Primary Malignant Neoplasm Of Fallopian Tube Cancer Of The Oviduct
Pericardium Cancer	Malignant Neoplasm Of Pericardium Malignant Tumor Of Pericardium Pericardial Tumor Neoplasm Of Pericardium
Epithelioid Sarcoma	Epithelioid Cell Sarcoma Sarcoma Epithelioid Sarcoma, Epithelioid
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Benign Peritoneal Mesothelioma	Mesothelioma Of Peritoneum Benign Neoplasm Of Mesothelial Tissue Of Peritoneum
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Thymus Sarcomatoid Carcinoma	Thymic Carcinosarcoma Thymic Sarcomatoid Carcinoma
Splenic Tuberculosis	Tuberculosis, Splenic
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99006	Amatuximab	Inhibitor	99.90%	Phase 2
HY-P99352	Anetumab	Inhibitor	98.78%	Phase 2

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P11058	OVA(250-264)		98.14%	Unkown
HY-185561	Misitatug blivedotin		/	Unkown
HY-171269	Anetumab-MMAE		/	Unkown
HY-P11025	TMVP1446		/	Unkown
HY-P11026	DOTA-TMVP1446		/	Unkown
HY-RS08719	MSLN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17193	Msln Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23644	Msln Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990833	Anti-Mesothelin Antibody (YP218)	Inhibitor	95.00%	Unkown
HY-P990929	Misitatug		99.00%	Unkown
HY-P99663	Inezetamab	Inhibitor	99.77%	Unkown
HY-P991315	Anti-MSLN/Mesothelin (h7D9.v3)		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MSLN	RGD	RGD:69333
Macaca mulatta	MSLN	VGNC	VGNC:74936
Mus musculus	MSLN	MGD	MGI:1888992
Others	MSLN	NCBI