AhR modulator-1
AhR modulator-1 (compound 6-MCDF) is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. AhR modulator-1 inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. AhR modulator-1 also possess anti-estrogenic properties in rat uterus.
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- CAS. Nr.: 118174-38-2
- Formel: C13H7Cl3O
- Molecular Weight:285.55
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Aryl hydrocarbon receptor (AhR) [1][2]
Prostatic VEGF[1]
Estrogenic[1]
AhR modulator-1 (6-MCDF; 0.1-10 μM; 48-96 hours; ASPC-1 cells) treatment exhibits dose-dependent growth inhibitory effects with growth inhibitory effects of 26, 43 and 99% at concentrations of 0.1, 1 and 10 μM, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:ASPC-1 cells
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Concentration:0.1 μM, 1 μM and 10 μM
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Incubation Time:48 hours, 72 hours, 96 hours
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Result:Exhibited dose-dependent growth inhibitory effects.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6-Tg(TRAMP)8247Ng/J (TRAMP) mice (8-week-old)[1]
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Dosage:0 mg/kg, 10 mg/kg, 40 mg/kg
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Administration:Oral administration; daily; for 12 weeks
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Result:The frequency of pelvic lymph node metastasis was reduced 5-fold in mice fed the 40 mg /kg diet.S erum VEGF concentrations were also reduced.
Chemical Information
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CAS. Nr. 118174-38-2
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Molecular Weight 285.55
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Formel C13H7Cl3O
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SMILES
CC1=C(OC2=CC(Cl)=CC(Cl)=C23)C3=CC(Cl)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Fritz WA, et al. The selective aryl hydrocarbon receptor modulator 6-methyl-1,3,8-trichlorodibenzofuran inhibits prostate tumor metastasis in TRAMP mice. Biochem Pharmacol. 2009 Apr 1;77(7):1151-60. [Content Brief]
[2]. Koliopanos A, et al. Increased arylhydrocarbon receptor expression offers a potential therapeutic target for pancreatic cancer. Oncogene. 2002 Sep 5;21(39):6059-70. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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