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Art. -Nr.: HY-159194

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DSPE-PEG2000-Cy5.5

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

DSPE-PEG2000-Cy5.5 is a phospholipid-fluorophore conjugate consisting of Cy5.5 covalently linked to 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE), serving as a surface label for liposomes in multimodal CT/optical imaging.DSPE-PEG2000-Cy5.5 can be used for the research of non-small cell lung cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₁₇₆H₃₁₁N₄O₅₅P
Molecular Weight:3394.32

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

DSPE-PEG2000-Cy5.5 Chemical Structure

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

DSPE-PEG2000-Cy5.5 (6.5 mM lipid concentration in FBS; 96 h at 37°C) containing liposomes release less than 25% of their Cy5.5 content over 96 hours of incubation at 37°C in fetal bovine serum^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The DSPE-PEG2000-Cy5.5-containing liposomes (1.8 g lipid/kg body weight; tail vein; single injection) exhibit a prolonged vascular half-life of 36.2 hours in non-tumor-bearing mice, with significantly higher accumulation in the liver and kidneys at select time points compared to CT-only liposomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CD-1 (athymic female, 6 weeks old, average weight 27 g)^[1]
Dosage:

1.8 g lipid/kg body weight (containing DSPE-PEG2000-Cy5.5 at a molar ratio of 0.02 relative to total lipids)
Administration:

tail vein; single injection
Result:

Exhibited a vascular half-life of 36.2 hours.
Showed statistically significant higher accumulation in the liver at 5 minutes and 24 hours postinjection compared to CT-only liposomes.
Showed statistically significant higher accumulation in the kidneys at 48, 72, and 96 hours postinjection compared to CT-only liposomes.
Had accumulation in the spleen equivalent to CT-only liposomes.

Chemical Information

Molecular Weight 3394.32
Formel C₁₇₆H₃₁₁N₄O₅₅P
SMILES

O=C(OC[C@]([H])(COP(OCCNC(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCCCC[N+]1=C(C(C)(C2=C1C=CC3=CC=CC=C23)C)/C=C/C=C/C=C4N(C5=C(C/4(C)C)C6=CC=CC=C6C=C5)C)=O)=O)([O-])=O)OC(CCCCCCCCCCCCCCCCCCC)=O)CCCCCCCCCCCCCCCCCCC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Mater Today Bio

Programmable nanomotor system responsively and chemotactically captures tumor associated antigens for enhanced in situ cancer vaccine. [Abstract]

2025 Nov 11:35:102543. PMID: 41322135

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Huang H, et al. Comparison of computed tomography- and optical image-based assessment of liposome distribution. Mol Imaging. 2013;12(3):148-160. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

DSPE-PEG2000-Cy5.5

1 Cited Publications

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Publications (1)
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DSPE-PEG2000-Cy5.5

Publications Citing Use of MedChemExpress (MCE) DSPE-PEG2000-Cy5.5

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Chemical Information

Publications (1)

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DSPE-PEG2000-Cy5.5 Related Classifications

HY-159194 Related Classifications