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Art. -Nr.: HY-17624S

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Framycetin-d₂

(Synonyms: Neomycin B-d₂; Fradiomycin B-d₂)

Framycetin-d₂ (Neomycin B-d₂) is the deuterium labeled Framycetin (HY-17624). Framycetin (Neomycin B), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a K_i of 35 μM. Framycetin competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin inhibits hammerhead ribozyme with a K_i of 13.5 μM. Framycetin, a 5″-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₃H₄₄D₂N₆O₁₃
Molecular Weight:616.66

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (250 KB)

Framycetin-d₂ Chemical Structure

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Biologische Aktivität
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Chemical Information
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Bioz

Biologische Aktivität

Beschreibung

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anwendung

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled Cas 119-04-0
Molecular Weight 616.66
Formel C₂₃H₄₄D₂N₆O₁₃
SMILES

N[C@@H](C[C@H]1N)[C@@]([C@@H]([C@H]1O)O[C@@](O[C@H](C([2H])([2H])O)[C@H]2O[C@@]([C@@H]([C@@H](O)[C@@H]3O)N)([H])O[C@H]3CN)([H])[C@@H]2O)([H])O[C@H]([C@@H]([C@@H](O)[C@@H]4O)N)O[C@@H]4CN
Synonyms

Neomycin B-d₂; Fradiomycin B-d₂
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.