GPN1 - GPN-loop GTPase 1 Gene

Also Known as XAB1; MBDIN; NTPBP; RPAP4; ATPBD1A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11321

About GPN1

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,628,247-27,651,511 (from NCBI)

This gene has 12 transcripts (splice variants), 204 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 15.4), thyroid (RPKM 13.8) and 25 other tissues.

Summary

This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

GPN1 Products (4)

mRNA Protein Name
NM_001145047.2 NP_001138519.1 GPN-loop GTPase 1 isoform b
NM_001145048.2 NP_001138520.1 GPN-loop GTPase 1 isoform c
NM_001145049.2 NP_001138521.1 GPN-loop GTPase 1 isoform d
NM_007266.4 NP_009197.3 GPN-loop GTPase 1 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
24981860 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPN1 Protein Structure

ATP_bind_1

ATP_bind_1: Conserved hypothetical ATP binding protein (24 - 263)

  • 0
  • 100
  • 200
  • 300
  • 374 a.a.
Protein Preferred Names Protein Names

GPN-loop GTPase 1

  • ATP(GTP)-binding protein

GPN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
GPN1 Q9HCN4 GPN2 Homo sapiens Q9H9Y4
Anti Tag CoIP
33961781
Intra
GPN1 Q9HCN4 GPN3 Homo sapiens Q9UHW5
Anti Tag CoIP
25241168
Intra
GPN1 Q9HCN4 RPAP2 Homo sapiens Q8IXW5
Anti Tag CoIP
33961781
Intra
GPN1 Q9HCN4 RPAP2 Homo sapiens Q8IXW5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Brain Sarcoma

  • Sarcoma Of The Brain
Xeroderma Pigmentosum, Complementation Group A

  • Xeroderma Pigmentosum Group A

  • Xp1

  • Xeroderma Pigmentosum, Group A

  • XPA

  • Xeroderma Pigmentosum I

  • Xeroderma Pigmentosum Complementation Group A

  • Xp Group A

  • Xp, Group A

  • Xeroderma Pigmentosum 1

  • Xeroderma Pigmentosum, Type 1

  • XP-A
Xeroderma Pigmentosum, Variant Type

  • Xeroderma Pigmentosum

  • XPV

  • Xeroderma Pigmentosum Variant Type

  • Xeroderma Pigmentosum With Normal Dna Repair Rates

  • Photosensitivity With Defective Dna Synthesis

  • Xp

  • De Sanctis-Cacchione Syndrome

  • Desanctis-Cacchione Syndrome

  • Xeroderma Pigmentosa

  • Xerodermic Idiocy

  • Xeroderma Pigmentosum Variant

  • Xp - [Xeroderma Pigmentosum]

  • Atrophoderma Pigmentosum
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-113225S5 Guanosine triphosphate-13C10 dilithium 99.4% Unkown
HY-113225S3 Guanosine triphosphate-15N5 dilithium 99.2% Unkown
HY-113225S2 Guanosine triphosphate-13C dilithium 98.2% Unkown
HY-113225S1 Guanosine triphosphate-13C10,15N5 tetraammonium solution (100 mM) 99.98% Unkown
HY-113225S4 Guanosine triphosphate-15N5,d14 dilithium 98.4% Unkown
HY-RS05645 GPN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-113225 Guanosine triphosphate / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GPN1 VGNC VGNC:72953
Mus musculus GPN1 MGD MGI:1921504
Bos taurus GPN1 VGNC VGNC:29538
Rattus norvegicus GPN1 RGD RGD:1589985
Felis catus GPN1 VGNC VGNC:62668
Others GPN1 NCBI