GPN3 - GPN-loop GTPase 3 Gene

Also Known as ATPBD1C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51184

About GPN3

This gene has 10 transcripts (splice variants), 213 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 19.7), fat (RPKM 10.4) and 25 other tissues.

Summary

Predicted to enable GTPase activity. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

GPN3 Products (3)

mRNA Protein Name
NM_001164372.2 NP_001157844.1 GPN-loop GTPase 3 isoform 2
NM_001164373.2 NP_001157845.1 GPN-loop GTPase 3 isoform 3
NM_016301.4 NP_057385.3 GPN-loop GTPase 3 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25241168 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPN3 Protein Structure

ATP_bind_1

ATP_bind_1: Conserved hypothetical ATP binding protein (8 - 254)

  • 0
  • 100
  • 200
  • 284 a.a.
Protein Preferred Names Protein Names

GPN-loop GTPase 3

  • ATP-binding domain 1 family member C

GPN3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GPN3 Q9UHW5 GPN1 Homo sapiens Q9HCN4
IF
25241168
Intra
GPN3 Q9UHW5 GPN1 Homo sapiens Q9HCN4
Anti Tag CoIP
25241168
Intra
GPN3 Q9UHW5 GPN1 Homo sapiens Q9HCN4
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
B-Lymphoblastic Leukemia/Lymphoma With Tcf3-Pbx1

  • B Acute Lymphoblastic Leukemia With T(1

  • 19)(Q23

  • P13.3)

  • E2a-Pbx1 (Tcf3-Pbx1)

  • B-All With Tcf3-Pbx1

  • B-Lymphoblastic Leukemia/Lymphoma With T(1

  • 19)(Q23

  • P13.3)

  • Tcf3-Pbx1
Microcephaly, Autosomal Dominant

  • Autosomal Dominant Microcephaly

  • Microcephaly Autosomal Dominant

  • Autosomal Dominant Primary Microcephaly

  • Microcephaly With Autosomal Dominant Inheritance
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-113225 Guanosine triphosphate / Phase 3

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05647 GPN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GPN3 VGNC VGNC:41388
Mus musculus GPN3 MGD MGI:1289326
Bos taurus GPN3 VGNC VGNC:29540
Rattus norvegicus GPN3 RGD RGD:1303034
Felis catus GPN3 VGNC VGNC:107707
Macaca mulatta GPN3 VGNC VGNC:73040
Others GPN3 NCBI