Alkbh1 - alkB homolog 1, histone H2A dioxygenase Gene

Also Known as Abh; alkB; hABH; Alkbh; 2700073G19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 211064

Summary

Enables chemoattractant activity and oxidative DNA demethylase activity. Involved in DNA demethylation and tRNA demethylation. Acts upstream of or within several processes, including generation of neurons; negative regulation of neuron apoptotic process; and placenta development. Located in euchromatin. Is expressed in several structures, including branchial arch; central nervous system; gonad; hemolymphoid system gland; and limb bud. Orthologous to human ALKBH1 (alkB homolog 1, histone H2A dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Alkbh1 Products (1)

mRNA Protein Name
NM_001102565.1 NP_001096035.1 nucleic acid dioxygenase ALKBH1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables broad specificity oxidative DNA demethylase activity IDA
IDA: Inferred from direct assay
27027282 MGI
enables chemoattractant activity IDA
IDA: Inferred from direct assay
16860792 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18163532 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within cell differentiation IMP
IMP: Inferred from mutant phenotype
18163532 MGI
acts upstream of or within developmental growth IMP
IMP: Inferred from mutant phenotype
18163532 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
18163532 MGI
acts upstream of or within negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
16860792 MGI
acts upstream of or within neuron migration IDA
IDA: Inferred from direct assay
16860792 MGI
acts upstream of or within neuron projection development IDA
IDA: Inferred from direct assay
16860792 MGI
acts upstream of or within placenta development IMP
IMP: Inferred from mutant phenotype
18163532 MGI
involved in positive regulation of gene expression, epigenetic IDA
IDA: Inferred from direct assay
27027282 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18163532 MGI
involved in regulation of translational initiation by tRNA modification IMP
IMP: Inferred from mutant phenotype
27745969 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in euchromatin IDA
IDA: Inferred from direct assay
18163532 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nucleic acid dioxygenase ALKBH1

  • Alkylated DNA repair protein alkB homolog 1

  • DNA 6mA demethylase

  • DNA N6-methyl adenine demethylase ALKBH1

  • DNA demethylase ALKBH1

  • DNA lyase ABH1

  • DNA oxidative demethylase ALKBH1

  • alkB, alkylation repair homolog 1

  • alpha-ketoglutarate-dependent dioxygen

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-163385 ALKBH1-IN-1 Inhibitor 99.63% Unkown
HY-158998 ALKBH1-IN-2 99.16% Unkown
HY-W002065 4-Carboxypyrazole 99.71% Unkown
HY-169131 ALKBH1-IN-3 prodrug Activator 99.15% Unkown
HY-168044 ALKBH1-IN-3 Activator / Unkown
HY-RS00603 ALKBH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18694 Alkbh1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25181 Alkbh1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alkbh1 NCBI NCBI:8846