ALKBH1 - alkB homolog 1, histone H2A dioxygenase Gene

Also Known as ABH; ABH1; alkB; hABH; ALKBH

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8846

About ALKBH1

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:77,672,404-77,708,023 (from NCBI)

This gene has 4 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in testis (RPKM 4.0), thyroid (RPKM 3.4) and 25 other tissues.

Summary

This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. [provided by RefSeq, Jul 2008]

ALKBH1 Products (1)

mRNA Protein Name
NM_006020.3 NP_006011.2 nucleic acid dioxygenase ALKBH1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 2-oxoglutarate-dependent dioxygenase activity IDA
IDA: Inferred from direct assay
27497299 GOA
enables broad specificity oxidative DNA demethylase activity IDA
IDA: Inferred from direct assay
18603530 GOA
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
IDA: Inferred from direct assay
19959401 GOA
enables ferrous iron binding IDA
IDA: Inferred from direct assay
18603530 GOA
enables oxidative RNA demethylase activity IDA
IDA: Inferred from direct assay
18603530 GOA
enables tRNA binding IDA
IDA: Inferred from direct assay
27497299 GOA
enables tRNA demethylase activity IDA
IDA: Inferred from direct assay
27745969 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA repair IDA
IDA: Inferred from direct assay
19959401 GOA
involved in oxidative RNA demethylation IDA
IDA: Inferred from direct assay
31188562 GOA
involved in positive regulation of gene expression, epigenetic IDA
IDA: Inferred from direct assay
30017583 GOA
involved in regulation of mitochondrial translation IMP
IMP: Inferred from mutant phenotype
27497299 GOA
involved in regulation of translational elongation IMP
IMP: Inferred from mutant phenotype
27745969 GOA
involved in regulation of translational initiation IMP
IMP: Inferred from mutant phenotype
27745969 GOA
involved in regulation of translational initiation by tRNA modification IDA
IDA: Inferred from direct assay
27745969 GOA
involved in tRNA wobble cytosine modification IDA
IDA: Inferred from direct assay
27497299 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
18603530 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALKBH1 Protein Structure

2OG-FeII_Oxy_2

2OG-FeII_Oxy_2: 2OG-Fe(II) oxygenase superfamily (99 - 344)

  • 0
  • 100
  • 200
  • 300
  • 389 a.a.
Protein Preferred Names Protein Names

nucleic acid dioxygenase ALKBH1

  • DNA 6mA demethylase

ALKBH1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80013 ALKBH1 Antibody (YA628) WB, IHC-P Human

Related Diseases

Diseases Alias
Plantar Fasciitis

  • Fasciitis, Plantar
Wilms Tumor 1

  • Nephroblastoma

  • Wilms Tumor

  • WT1

  • Wilms' Tumor

  • Bilateral Wilms Tumor

  • Wilms Tumor, Type 1

  • Wilms Tumor, Somatic

  • Adult Nephroblastoma

  • Wt1 Disorder

  • Renal Embryonic Tumor

  • Adult Kidney Wilms Tumor

  • Childhood Kidney Wilms Tumor

  • Nonanaplastic Kidney Wilms Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-163385 ALKBH1-IN-1 Inhibitor 99.63% Unkown
HY-158998 ALKBH1-IN-2 99.16% Unkown
HY-W002065 4-Carboxypyrazole 99.71% Unkown
HY-169131 ALKBH1-IN-3 prodrug Activator 99.15% Unkown
HY-168044 ALKBH1-IN-3 Activator / Unkown
HY-RS00603 ALKBH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18694 Alkbh1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25181 Alkbh1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ALKBH1 VGNC VGNC:69630
Bos taurus ALKBH1 VGNC VGNC:55101
Mus musculus ALKBH1 MGD MGI:2384034
Canis familiaris ALKBH1 VGNC VGNC:50620
Felis catus ALKBH1 VGNC VGNC:81038
Rattus norvegicus ALKBH1 RGD RGD:1308327
Others ALKBH1 NCBI