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PLEKHB2 - pleckstrin homology domain containing B2 Gene

Also Known as EVT2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55041

About PLEKHB2

Cytogenetic location: 2q21.1 Genomic coordinates (GRCh38): 2:131,105,336-131,149,845 (from NCBI)

This gene has 12 transcripts (splice variants), 198 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 52.2), brain (RPKM 41.1) and 24 other tissues.

Summary

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in regulation of cell differentiation. Predicted to be located in recycling endosome membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

PLEKHB2 Products (13)

mRNA	Protein	Name
NM_001100623.2	NP_001094093.1	pleckstrin homology domain-containing family B member 2 isoform 3
NM_001267062.2	NP_001253991.1	pleckstrin homology domain-containing family B member 2 isoform 4
NM_001267063.2	NP_001253992.1	pleckstrin homology domain-containing family B member 2 isoform 5
NM_001267064.2	NP_001253993.1	pleckstrin homology domain-containing family B member 2 isoform 6
NM_001267065.2	NP_001253994.1	pleckstrin homology domain-containing family B member 2 isoform 7
NM_001267066.2	NP_001253995.1	pleckstrin homology domain-containing family B member 2 isoform 8
NM_001267067.2	NP_001253996.1	pleckstrin homology domain-containing family B member 2 isoform 9
NM_001267068.2	NP_001253997.1	pleckstrin homology domain-containing family B member 2 isoform 10
NM_001309448.2	NP_001296377.1	pleckstrin homology domain-containing family B member 2 isoform 11
NM_001309450.2	NP_001296379.1	pleckstrin homology domain-containing family B member 2 isoform 12
NM_001309451.2	NP_001296380.1	pleckstrin homology domain-containing family B member 2 isoform 13
NM_001309452.2	NP_001296381.1	pleckstrin homology domain-containing family B member 2 isoform 11
NM_017958.3	NP_060428.2	pleckstrin homology domain-containing family B member 2 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: Inferred from direct assay	11001876	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLEKHB2 Protein Structure

0
100
200
222 a.a.

Protein Preferred Names	Protein Names
pleckstrin homology domain-containing family B member 2	PH domain-containing family B member 2

PLEKHB2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	PLEKHB2	Q96CS7	GGA3	Homo sapiens	Q9NZ52-2	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	GGA3	Homo sapiens	Q9NZ52-2	Y2H Array	32296183
Intra	PLEKHB2	Q96CS7	GGA3	Homo sapiens	Q9NZ52-2	Validated Y2H	32296183
Intra	PLEKHB2	Q96CS7	EPN2	Homo sapiens	O95208-2	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	EPN2	Homo sapiens	O95208-2	Y2H Array	32296183
Intra	PLEKHB2	Q96CS7	UBXN6	Homo sapiens	Q9BZV1	Validated Y2H	32296183
Intra	PLEKHB2	Q96CS7	UBC	Homo sapiens	P0CG48	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	UBC	Homo sapiens	P0CG48	Y2H Array	32296183
Intra	PLEKHB2	Q96CS7	UBA52	Homo sapiens	P62987	Y2H Array	32296183
Intra	PLEKHB2	Q96CS7	UBA52	Homo sapiens	P62987	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	RPS27A	Homo sapiens	P62979	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	RPS27A	Homo sapiens	P62979	Y2H Array	32296183
Intra	PLEKHB2	Q96CS7	STAM2	Homo sapiens	O75886	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	STAM2	Homo sapiens	O75886	Y2H Prey Pooling	25416956
Intra	PLEKHB2	Q96CS7	STAM2	Homo sapiens	O75886	Validated Y2H	25416956
Intra	PLEKHB2	Q96CS7	STAM2	Homo sapiens	O75886	Y2H Array	32296183
Intra	PLEKHB2	Q96CS7	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	32296183
Intra	PLEKHB2	Q96CS7	TAX1BP1	Homo sapiens	Q86VP1	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	BHLHE40	Homo sapiens	O14503	Y2H Array	25416956
Intra	PLEKHB2	Q96CS7	EPN1	Homo sapiens	Q9Y6I3	Y2H Array	25416956
Intra	PLEKHB2	Q96CS7	HEY1	Homo sapiens	Q9Y5J3	Validated Y2H	32296183
Intra	PLEKHB2	Q96CS7	DAZAP2	Homo sapiens	Q15038	Validated Y2H	25416956
Intra	PLEKHB2	Q96CS7	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	PLEKHB2	Q96CS7	GLIS2	Homo sapiens	Q9BZE0	Validated Y2H	32296183
Intra	PLEKHB2	Q96CS7	DCUN1D1	Homo sapiens	Q96GG9	Validated Y2H	32296183
Intra	PLEKHB2	Q96CS7	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	PLEKHB2	Q96CS7	OTUB2	Homo sapiens	Q96DC9	Validated Y2H	32296183
Intra	PLEKHB2	Q96CS7	UBAC1	Homo sapiens	Q9BSL1	Validated Y2H	32296183
Intra	PLEKHB2	Q96CS7	UBAC1	Homo sapiens	Q9BSL1	Y2H Array	32296183
Intra	PLEKHB2	Q96CS7	UBAC1	Homo sapiens	Q9BSL1	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	HEYL	Homo sapiens	Q9NQ87	Validated Y2H	32296183
Intra	PLEKHB2	Q96CS7	CDA	Homo sapiens	P32320	Y2H Prey Pooling	25416956
Intra	PLEKHB2	Q96CS7	CDA	Homo sapiens	P32320	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	CDA	Homo sapiens	P32320	Y2H Array	25416956
Intra	PLEKHB2	Q96CS7	CDA	Homo sapiens	P32320	Y2H Array	32296183
Intra	PLEKHB2	Q96CS7	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	25416956
Intra	PLEKHB2	Q96CS7	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	25416956
Intra	PLEKHB2	Q96CS7	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	PLEKHB2	Q96CS7	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	PLEKHB2	Q96CS7	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hypogonadotropic Hypogonadism 4 With Or Without Anosmia	HH4 Kallmann Syndrome 4 Kal4 Hypogonadotropic Hypogonadism, Type 4 With/Without Anosmia
Articulation Disorder	Phonological Disorder Articulation Disorders Articulation Impairment Speech Sound Disorders
Vertebral Artery Insufficiency	Vertebral Artery Syndrome
Intellectual Disability-Severe Speech Delay-Mild Dysmorphism Syndrome	Foxp1 Syndrome Mental Retardation With Language Impairment And With Or Without Autistic Features Foxp1 Related Global Developmental Delay, Intellectual Disability And Speech Defects Intellectual Disability With Language Impairment And With Or Without Autistic Features
Speech And Communication Disorders	Language Disorder Communication Disorder Language Disorders Communication Disorders Speech Language Disorder Speech-Language Disorder Communication Impairment Speech And Language Disorder
Speech Disorder	Speech Disorders
Stuttering	Stammering Familial Persistent Stuttering Stuttering, Familial Persistent 1
Specific Language Impairment	Language Impairment, Specific
Reading Disorder	Specific Reading Disorder Reading Dyslexia Developmental Reading Disorder
Separation Anxiety Disorder	Separation Anxiety Disorder Of Childhood
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS10686	PLEKHB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PLEKHB2	RGD	RGD:1310954
Canis familiaris	PLEKHB2	VGNC	VGNC:44673
Mus musculus	PLEKHB2	MGD	MGI:2385825
Felis catus	PLEKHB2	VGNC	VGNC:64222
Bos taurus	PLEKHB2	VGNC	VGNC:33010
Others	PLEKHB2	NCBI