CCL24 - C-C motif chemokine ligand 24 Gene

Also Known as Ckb-6; MPIF2; MPIF-2; SCYA24

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6369

About CCL24

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:75,810,825-75,823,372 (from NCBI)

This gene has 2 transcripts (splice variants), 100 orthologues and 25 paralogues. Biased expression in small intestine (RPKM 18.6), colon (RPKM 9.1) and 8 other tissues.

Summary

This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. This protein also has antimicrobial activity, displaying an Antibacterial effect on S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa. Finally, the protein is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. [provided by RefSeq, Jul 2020]

CCL24 Products (2)

mRNA	Protein	Name
NM_001371193.1	NP_001358122.1	C-C motif chemokine 24 precursor
NM_002991.3	NP_002982.2	C-C motif chemokine 24 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables CCR3 chemokine receptor binding	IDA IDA: Inferred from direct assay	11425309	GOA
enables chemokine activity	IDA IDA: Inferred from direct assay	10072545	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28381538	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	11425309	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cytoskeleton organization	IDA IDA: Inferred from direct assay	10072545	GOA
involved in eosinophil chemotaxis	IDA IDA: Inferred from direct assay	10072545	GOA
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	19525930	GOA
involved in positive regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	19525930	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	19525930	GOA
involved in positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	19525930	GOA
involved in regulation of cell shape	IDA IDA: Inferred from direct assay	10072545	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCL24 Protein Structure

IL8

0
100
119 a.a.

Protein Preferred Names	Protein Names
C-C motif chemokine 24	CK-beta-6

CCL24 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	CCL24	O00175	CCL5	Homo sapiens	P13501	SPR	28381538
Intra	CCL24	O00175	CCL5	Homo sapiens	P13501	Filter Binding	28381538
Intra	CCL24	O00175	CXCL11	Homo sapiens	O14625	Filter Binding	28381538

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CCL24 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P7161	CCL24/Eotaxin-2 Protein, Human	O00175 (V27-A104)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7766	CCL24/Eotaxin-2 Protein, Human (HEK293, His)	O00175 (V27-C119)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Vernal Keratoconjunctivitis	Vkc Spring Catarrh Keratoconjunctivitis Vernal Keratoconjunctivitis, Vernal
Allergic Asthma	Atopic Asthma Extrinsic Asthma Extrinsic Asthma With Acute Exacerbation Extrinsic Asthma With Status Asthmaticus Asthma Allergic Atopic Asthma, Susceptibility To Ige-Mediated Allergic Asthma Allergen-Induced Asthma Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Allergic Asthma Nos Catarrh With Asthma Allergic Bronchitis Nos Extrinsic Allergic Asthma Predominantly Allergic Asthma With Stated Status Asthmaticus
Neurosyphilis	Syphilis Of Central Nervous System Late Syphilis Of Central Nervous System Nos Late Syphilis Of The Central Nervous System Gumma Of Central Nervous System Neurosyphilis Gumma Neurosyphilitic Gumma Syphilis Of Central Nervous System Nos Syphilitic Gumma Of Central Nervous System Tertiary Central Nervous System Syphilis
Parenchymatous Neurosyphilis
Mansonelliasis	Mansonellosis Mansonella Perstans Infections Mansonella Infestation
Hypereosinophilic Syndrome	Eosinophilia HES Eosinophilic Leukocytosis Hypereosinophilic Syndrome, Idiopathic Idiopathic Hypereosinophilic Syndrome Disseminated Eosinophilic Collagen Disease Eosinophilic Disorder Disorders With Increased Eosinophil Counts
Allergic Disease	Hypersensitivity Allergic Hypersensitivity Disease Allergic Condition Allergic Reaction Allergic Disposition
Allergic Rhinitis	Hay Fever Allergic Rhinitis, Susceptibility To ALRH Atopic Rhinitis Seasonal Allergic Rhinitis Non-Seasonal Allergic Rhinitis Perenial Allergic Rhinitis Pollenosis Rhinitis Allergic Seasonal Rhinitis, Allergic, Perennial Allergic Rhinitis, Cause Unspecified Pollinosis Pollen Allergy Allergy Nos Due To Pollen Summer Catarrh Other Seasonal Allergic Rhinitis
Esophagitis	Acute Esophagitis
Papillary Conjunctivitis
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Conjunctivitis	Madras Eye Adenoviral Conjunctivitis Acute Adenoviral Follicular Conjunctivitis Inclusion Conjunctivitis Of The Adult Swimming-Pool Conjunctivitis Inflammation Of Conjunctiva Ophthalmia Acute Conjunctivitis Eye Catarrh Catarrhal Ophthalmia Koch-Weeks Conjunctivitis
Giant Papillary Conjunctivitis	Gpc Conjunctivitis Giant Papillary Conjunctivitis, Giant Papillary Chronic Giant Papillary Conjunctivitis Chronic Papillary Conjunctivitis
Esophagitis, Eosinophilic, 1	Eosinophilic Esophagitis EOE1 Esophagitis, Eosinophilic Ee
Eosinophilic Gastritis	Eosinophilic Enteropathy
Angiostrongyliasis	A. Cantonensis Angiostrongyliasis
Chronic Asthma
Respiratory Allergy	Airway Allergy
Bronchial Disease	Bronchial Diseases Bronchial Disorders Bronchial Spasm
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-P991010	Nebokitug	Inhibitor	98.80%	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS02094	CCL24 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174758	Human CCL24 mRNA		/	Unkown
HY-RS16957	Ccl24 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23400	Ccl24 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CCL24	VGNC	VGNC:38886
Macaca mulatta	CCL24	VGNC	VGNC:80856
Mus musculus	CCL24	MGD	MGI:1928953
Bos taurus	CCL24	VGNC	VGNC:26950
Felis catus	CCL24	VGNC	VGNC:60544
Rattus norvegicus	CCL24	RGD	RGD:1310245
Others	CCL24	NCBI