PDE3B-IN-1
Based on 1 Customer Validation
PDE3B-IN-1 is a potent selective PDE3B inhibitor that demonstrates PDE3B inhibitory activity (pIC50 = 6.5) and >300-fold PDE3B/A selectivity.
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- Reinheit: 99.60%
- CAS. Nr.: 3032458-01-5
- Formel: C23H26BN3O7
- Molecular Weight:467.28
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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PDE3B 6.5 (pIC50) |
PDE3A <4.0 (pIC50) |
PDE3B-IN-1 (compound 18) demonstrates high selectivity by exhibiting minimal activity against PDE3A (pIC50 < 4.0)[1].
PDE3B-IN-1 (10 μM) exhibits limited but significant activity in an adipocyte lipolysis assay, which measures PDE-mediated hydrolysis of cAMP to 5’-AMP, resulting in reduced lipolysis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3032458-01-5
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Appearance Solid
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Molecular Weight 467.28
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Formel C23H26BN3O7
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Color White to off-white
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SMILES
O=C(C1=CC(NC(C2=NC3=CC(OC)=CC=C3C(OC)=C2)=O)=CC(B(O)O)=C1)NC(C)COC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (214.00 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (10.70 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1400 mL | 10.7002 mL | 21.4004 mL | 53.5011 mL |
| 5 mM | 0.4280 mL | 2.1400 mL | 4.2801 mL | 10.7002 mL | |
| 10 mM | 0.2140 mL | 1.0700 mL | 2.1400 mL | 5.3501 mL | |
| 15 mM | 0.1427 mL | 0.7133 mL | 1.4267 mL | 3.5667 mL | |
| 20 mM | 0.1070 mL | 0.5350 mL | 1.0700 mL | 2.6751 mL | |
| 25 mM | 0.0856 mL | 0.4280 mL | 0.8560 mL | 2.1400 mL | |
| 30 mM | 0.0713 mL | 0.3567 mL | 0.7133 mL | 1.7834 mL | |
| 40 mM | 0.0535 mL | 0.2675 mL | 0.5350 mL | 1.3375 mL | |
| 50 mM | 0.0428 mL | 0.2140 mL | 0.4280 mL | 1.0700 mL | |
| 60 mM | 0.0357 mL | 0.1783 mL | 0.3567 mL | 0.8917 mL | |
| 80 mM | 0.0268 mL | 0.1338 mL | 0.2675 mL | 0.6688 mL | |
| 100 mM | 0.0214 mL | 0.1070 mL | 0.2140 mL | 0.5350 mL |
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