trans-PX20606
Based on 3 publication(s) in Google Scholar
PX20606 trans racemate (PX-102 trans racemate) is a FXR agonist with EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.24%
- CAS. Nr.: 1268244-85-4
- Formel: C29H22Cl3NO4
- Molecular Weight:554.85
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Publications Citing Use of MedChemExpress (MCE) trans-PX20606
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Biologische Aktivität
EC50: 32 nM (FXR in FRET assay), 34 nM (FXR in M1H assay)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
186 nM
Compound: 7a
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Agonist activity at C-terminal Gal4-tagged human FXR (187 to 472 residues) expressed in HEK-293 cells co-expressing pFRluc by mammalian one hybrid assay
Agonist activity at C-terminal Gal4-tagged human FXR (187 to 472 residues) expressed in HEK-293 cells co-expressing pFRluc by mammalian one hybrid assay
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[PMID: 27268696] |
| HEK293 | EC50 |
47 nM
Compound: 7b
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Agonist activity at C-terminal Gal4-tagged human FXR (187 to 472 residues) expressed in HEK-293 cells co-expressing pFRluc by mammalian one hybrid assay
Agonist activity at C-terminal Gal4-tagged human FXR (187 to 472 residues) expressed in HEK-293 cells co-expressing pFRluc by mammalian one hybrid assay
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[PMID: 27268696] |
Chemical Information
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CAS. Nr. 1268244-85-4
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Appearance Solid
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Molecular Weight 554.85
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Formel C29H22Cl3NO4
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Color White to off-white
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SMILES
O=C(O)C1=CC=C([C@H]2[C@H](C3=CC=C(OCC4=C(C5CC5)ON=C4C6=C(Cl)C=CC=C6Cl)C=C3Cl)C2)C=C1
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Synonyms
trans-PX-102
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Arch Toxicol
Farnesoid X receptor (FXR) agonists induce hepatocellular apoptosis and impair hepatic functions via FXR/SHP pathway. [Abstract]2022 Jun;96(6):1829-1843. PMID: 35267068 -
Biochem Pharmacol
2025 Oct 23:117451. PMID: 41138926 -
Biochem Pharmacol
FXR agonists for colorectal and liver cancers, as a stand-alone or in combination therapy. [Abstract]2023 Jun:212:115570. PMID: 37119860
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (180.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8023 mL | 9.0114 mL | 18.0229 mL | 45.0572 mL |
| 5 mM | 0.3605 mL | 1.8023 mL | 3.6046 mL | 9.0114 mL | |
| 10 mM | 0.1802 mL | 0.9011 mL | 1.8023 mL | 4.5057 mL | |
| 15 mM | 0.1202 mL | 0.6008 mL | 1.2015 mL | 3.0038 mL | |
| 20 mM | 0.0901 mL | 0.4506 mL | 0.9011 mL | 2.2529 mL | |
| 25 mM | 0.0721 mL | 0.3605 mL | 0.7209 mL | 1.8023 mL | |
| 30 mM | 0.0601 mL | 0.3004 mL | 0.6008 mL | 1.5019 mL | |
| 40 mM | 0.0451 mL | 0.2253 mL | 0.4506 mL | 1.1264 mL | |
| 50 mM | 0.0360 mL | 0.1802 mL | 0.3605 mL | 0.9011 mL | |
| 60 mM | 0.0300 mL | 0.1502 mL | 0.3004 mL | 0.7510 mL | |
| 80 mM | 0.0225 mL | 0.1126 mL | 0.2253 mL | 0.5632 mL | |
| 100 mM | 0.0180 mL | 0.0901 mL | 0.1802 mL | 0.4506 mL |
trans-PX20606 Related Classifications
HY-100443A Related Classifications
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