CCR4 - C-C motif chemokine receptor 4 Gene

Also Known as CKR4; K5-5; CD194; CMKBR4; ChemR13; CC-CKR-4; HGCN:14099

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1233

About CCR4

Cytogenetic location: 3p22.3 Genomic coordinates (GRCh38): 3:32,951,644-32,956,349 (from NCBI)

This gene has 1 transcript (splice variant), 114 orthologues, 23 paralogues and is associated with 42 phenotypes. Biased expression in appendix (RPKM 6.5), urinary bladder (RPKM 6.3) and 12 other tissues.

Summary

The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008]

CCR4 Products (2)

mRNA	Protein	Name
NM_005508.5	NP_005499.1	C-C chemokine receptor type 4
XM_017005687.2	XP_016861176.1	C-C chemokine receptor type 4 isoform X1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28381538	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCR4 Protein Structure

7tm_1

0
100
200
300
360 a.a.

Protein Preferred Names	Protein Names
C-C chemokine receptor type 4	C-C CKR-4 CCR-4 chemokine (C-C motif) receptor 4 chemokine (C-C) receptor 4

CCR4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCR4	P51679	CCL17	Homo sapiens	Q92583	FACS	28381538

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CCR4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700399	CCR4 Protein-VLP, Human (HEK293, His)	P51679 (M1-L360)	Purity analysis by SDS-PAGE is not available for VLP proteins.

CCR4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810139	CKR-4 Antibody (YA9483)	WB, ICC/IF, IF-Tissue, IP, ELISA	human
HY-P811054	CCR4 Antibody	WB, IHC-P	Human, Mouse, Dog

Related Diseases

Diseases	Alias
Ileitis	Crohn'S Ileitis
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Granulomatosis With Polyangiitis	GPA Wegener Granulomatosis Wegener Granulomatosis, Formerly Midline Granulomatosis Wg, Formerly Necrotizing Respiratory Granulomatosis Wg Wegeners Granulomatosis Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Allergic Contact Dermatitis	Dermatitis, Allergic Contact Contact Dermatitis, Allergic Dermatitis Allergic Contact Allergic Contact Eczema Acd - [Allergic Contact Dermatitis] Allergic Contact Dermatitis, Unspecified Cause Allergic Dermatitis Allergic Eczema Allergy Dermatitis Allergy Eczema Allergic Contact Eczema Due To Clothing Or Footwear Perfume Allergic Contact Dermatitis Allergic Contact Dermatitis Due To Cosmetics Allergic Contact Eczema Due To Cosmetics Or Fragrances Allergic Contact Eczema Due To Dental Materials Allergic Contact Eczema Due To Food Flavours Or Additives Allergic Contact Eczema Due To Hairdressing Products Allergic Contact Eczema Due To Metals Or Metal Salts Allergic Contact Eczema Due To Proteins Allergic Contact Eczema Due To Plastics Or Resin Systems Allergic Contact Eczema Due To Preservatives Or Biocides Allergic Contact Eczema Due To Rubber Chemicals Rubber Dermatitis Allergic Contact Eczema Due To Systemic Medicaments Allergic Contact Eczema Due To Topical Medicaments Allergic Contact Dermatitis Due To Drugs In Contact With Skin
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Intermediate Uveitis	Uveitis, Intermediate Chronic Cyclitis Peripheral Uveoretinitis Iu Uveitis Intermediate
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Disease Primary Immunodeficiency Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Anaplastic Large Cell Lymphoma	Alcl Cd30 Positive Anaplastic Large Cell Lymphoma Ki-1 Positive Anaplastic Large Cell Lymphoma Primary Systemic Alcl Sacl Ki-1+ Anaplastic Large Cell Lymphoma
Pulmonary Fibrosis	Fibrosis Of Lung
Psoriasis
Lymphoproliferative Syndrome, X-Linked, 1	Lymphomatoid Papulosis Duncan Disease Purtilo Syndrome X-Linked Lymphoproliferative Syndrome Xlp XLP1 Lyp X-Linked Lymphoproliferative Disease Lymphoproliferative Disease, X-Linked Xlpd X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency Ebv Infection, Severe, Susceptibility To Ebvs Immunodeficiency 5 Imd5 X-Linked Lymphoproliferative Syndrome 1 Epstein-Barr Virus Infection, Familial Fatal Ebv Infection, Severe Infectious Mononucleosis, Severe Infectious Mononucleosis, Severe, Susceptibility To Immunodeficiency, X-Linked Progressive Combined Variable Epstein Barr Virus Infection, Familial Fatal X-Linked Progressive Combined Variable Immunodeficiency 5 Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males Familial Fatal Epstein-Barr Infection Severe Susceptibility To Ebv Infection Severe Susceptibility To Infectious Mononucleosis Sap Deficiency Sh2d1a/Slam-Associated Protein Deficiency X-Linked Lymphoproliferative Syndrome Type 1 X-Linked Progressive Combined Variable Immunodeficiency Lymphoproliferative Syndrome, X-Linked Sap X-Linked Lymphoproliferative Disorder
T-Cell Adult Acute Lymphocytic Leukemia	Acute Adult T-Cell Leukemia-Lymphoma Adult Precursor T Lymphoblastic Leukemia Atll T-Cell Adult Acute Lymphoblastic Leukemia
Peripheral T-Cell Lymphoma	Lymphoma T-Cell Peripheral
Sezary'S Disease	Sezary Syndrome Sézary Syndrome Sezary'S Lymphoma Sezary Disease Sezary Erythroderma Sezary Lymphoma
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified
Mycosis Fungoides	Mycosis Fungoides Lymphoma Alibert-Bazin Syndrome Granuloma Fungoides Classic Mycosis Fungoides Mycosis Fungoides, Alibert-Bazin Type
Adult T-Cell Leukemia/Lymphoma	Adult T-Cell Leukemia Atll Adult T-Cell Leukaemia Adult T-Cell Leukaemia/Lymphoma Adult T-Cell Lymphoma T Cell Leukemia Lymphoma Adult Leukemia-Lymphoma, Adult T-Cell Leukemia, T-Cell Adult T-Cell Lymphoma/Leukemia
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Cryptogenic Fibrosing Alveolitis Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Dermatitis	Eczema Skin Inflammation Inflammatory Dermatosis
Primary Cutaneous T-Cell Non-Hodgkin Lymphoma	Cutaneous T-Cell Lymphoma Cutaneous T Cell Lymphoma Lymphoma, T-Cell, Cutaneous Ctcl Lymphoma T-Cell Cutaneous

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99253	Mogamulizumab	Inhibitor	96.9%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-148074	Zelnecirnon	Inhibitor	99.71%	Phase 2
HY-148494	Tivumecirnon	Antagonist	99.48%	Phase 2
HY-100183	GSK2239633A	Antagonist	99.81%	Phase 1

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-U00064	AZD2098	Inhibitor	99.91%	Unkown
HY-103364A	C-021 dihydrochloride	Antagonist	99.73%	Unkown
HY-103364	C-021	Inhibitor	99.95%	Unkown
HY-157453	CCR4 antagonist 4	Antagonist	98.92%	Unkown
HY-P3418	CKLF1-C27	Inhibitor	98.02%	Unkown
HY-P3982	CKLF1-C19	Chemical	99.11%	Unkown
HY-131349	CCR4-351	Antagonist	98.95%	Unkown
HY-131349A	CCR4-351 hydrochloride	Antagonist	98.14%	Unkown
HY-147385	CCR4 antagonist 3	Antagonist	99.94%	Unkown
HY-122565	GSK-2239633	Antagonist	/	Unkown
HY-P3418A	CKLF1-C27 TFA	Inhibitor	/	Unkown
HY-182564	ST45177901	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CCR4	RGD	RGD:620594
Mus musculus	CCR4	MGD	MGI:107824
Felis catus	CCR4	VGNC	VGNC:60573
Bos taurus	CCR4	VGNC	VGNC:26985
Canis familiaris	CCR4	VGNC	VGNC:38913
Macaca mulatta	CCR4	VGNC	VGNC:70739
Others	CCR4	NCBI